Cincinnati, OH Clinical Trials Report — May 2026

For Cincinnati residents considering participation in clinical research, May 2026 offers both urgent opportunities and exciting new avenues to contribute to medical science. Across Cincinnati, 1,059 clinical trials are currently recruiting at 346 research facilities, providing numerous ways to engage with cutting-edge medical advancements.

Act Now: Trials Nearing Their Close

A total of 65 clinical trials in Cincinnati are slated to conclude within the next 90 days, making prompt action essential for interested individuals. This urgency is particularly relevant for healthy volunteers, as 7 of these rapidly closing studies are still actively seeking participants without specific health conditions. These trials offer a chance to contribute to medical advancements before their enrollment windows close.

Patients managing specific health conditions also face impending deadlines to join research. Trials focused on various conditions are among those with limited time remaining for enrollment. Conditions with trials closing soon include:

• Advanced solid tumor (4 trials)
• Epilepsy (3 trials)
• Idiopathic hypersomnia (2 trials)
• Adenine phosphoribosyltransferase deficiency (1 trial)
• AKI (1 trial)
• Anxiety (1 trial)
• Advanced solid tumors (1 trial)
• Aortic regurgitation (1 trial)
• Aortic valve insufficiency (1 trial)
• Atopic dermatitis (1 trial)

New Research Opportunities Emerge

This month, Cincinnati saw the opening of 9 new clinical trials. While this is a slight decrease from the 13 trials that launched in March 2026, these new studies bring important opportunities for patients and volunteers.

New trials this month are exploring a range of conditions, with a notable focus on metabolic and pain-related issues. The most frequent conditions addressed in these new studies include:

• Obesity (4 trials)
• Overweight (3 trials)
• Obstructive sleep apnoea (2 trials)
• Fibromyalgia (1 trial)
• Heart failure (1 trial)
• Juvenile idiopathic arthritis (JIA) (1 trial)
• Lupus (1 trial)
• Musculoskeletal pain (1 trial)
• Pectus excavatum (1 trial)
• Scoliosis (1 trial)

The majority of these new studies are drug trials, with 5 new drug trials, followed by 2 "OTHER" type trials, 1 diagnostic test, 1 dietary supplement, and 1 procedure trial. Industry sponsors are leading 5 of these new studies, while academic or other institutions are sponsoring 4.

Spotlight on Major Research Initiatives

May brings several high-profile new trials to Cincinnati, including significant Phase 2 and 3 studies from major sponsors. These trials offer participants the chance to engage with cutting-edge treatments and diagnostic approaches across a range of health challenges.

• Novo Nordisk A/S is initiating a notable Phase 3 study, NCT07567001, "A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity." This trial aims for 5,610 participants to evaluate the safety and effect of NNC0487-0111 in individuals with Heart Failure with preserved or mildly reduced Ejection Fraction and excess body weight.
• Another significant Phase 3 trial from Novo Nordisk A/S is NCT07571005, "AMAZE 3: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Not Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea." This study aims for 300 participants to assess the efficacy and safety of NNC0487-0111 in people with excess body weight and obstructive sleep apnea.
• Eli Lilly and Company is sponsoring a Phase 2 study, NCT07589608, "A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight." This trial, part of a larger master protocol, aims for 400 participants to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in adults with obesity or overweight without type 2 diabetes.
• Janssen Research & Development, LLC is leading a Phase 3 study, NCT07573176, "A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder." This trial aims for 600 participants to assess the efficacy of the study drug (JNJ-42847922) compared with placebo in improving depressive symptoms in participants with major depressive disorder.
• Children's Hospital Medical Center, Cincinnati is sponsoring NCT07602595, "The BRIDGE Pain Study." This study aims for 600 participants to discover at least two distinct musculoskeletal pain subtypes, investigating how different brain-and-immune system signals affect pain perception.
• The University of California, San Francisco is sponsoring NCT07579364, "Outcomes Tracking in Unilateral Vocal Fold Paralysis (UVFP) and Atrophy After Medialization Laryngeal Surgery." This observational study with 500 participants seeks to understand the long-term outcomes of Laryngeal Framework Surgery in patients with Unilateral Vocal Fold Paralysis or Vocal Fold Atrophy.

Opportunities for Healthy Volunteers

For individuals without a specific medical condition, there are limited but important opportunities to contribute to research this month. Of the 9 new trials launched, 0 are currently accepting healthy volunteers. However, across Cincinnati, a total of 86 clinical trials are still actively recruiting healthy participants, providing numerous avenues for those interested in supporting medical research.

Cincinnati's Leading Research Facilities

Cincinnati is home to several prominent research institutions that consistently run a high volume of clinical trials. These facilities are key destinations for individuals seeking to participate in medical research:

• Cincinnati Children's Hospital Medical Center (252 trials)
• University of Cincinnati (109 trials)
• University of Cincinnati Medical Center (63 trials)
• University of Cincinnati Cancer Center-UC Medical Center (56 trials)
• Good Samaritan Hospital - Cincinnati (49 trials)
• Bethesda North Hospital (44 trials)
• TriHealth Cancer Institute-Anderson (38 trials)
• TriHealth Cancer Institute-Westside (38 trials)
• The Christ Hospital (38 trials)
• Cincinnati Children's Hospital (37 trials)
• Oncology Hematology Care Inc-Kenwood (30 trials)
• Research Site (26 trials)

These institutions offer a broad spectrum of research, from pediatric care and specialized studies at Cincinnati Children's Hospital Medical Center to diverse medical fields at the University of Cincinnati and its associated medical centers, as well as comprehensive cancer research at specialized institutes.

Broadening Your Search: Nearby Options

While Cincinnati offers a vast array of clinical trial opportunities, individuals may also find options in nearby communities within Ohio. Cities with active trials include Columbus (25 trials), Cleveland (18 trials), Maumee (3 trials), Dayton (3 trials), South Euclid (1 trial), Vandalia (1 trial), Beachwood (1 trial), and Westlake (1 trial).

Who Can Participate?

Participation in clinical trials is open to a diverse range of individuals. Of the 9 new trials launched this month, 7 include older adults, ensuring that senior populations have ample opportunity to contribute to medical science. Additionally, 2 new trials include children. No new trials this month are exclusively for females or males.

As we move through May, Cincinnati's robust research community continues to drive medical innovation, offering diverse opportunities for individuals to contribute to the future of healthcare.