Cincinnati, OH Clinical Trials Report — April 2026

April 2026 presents a crucial window for Cincinnati residents considering participation in clinical research, particularly for those looking to join studies before enrollment concludes. Across the city, 67 clinical trials are slated to close within the next 90 days. This urgency is especially relevant for healthy volunteers, as 7 of these rapidly closing studies are still actively seeking participants without specific health conditions. Individuals interested in contributing to medical advancements should explore these options promptly.

New Research Opportunities Emerge in Cincinnati

This month, Cincinnati saw the opening of 8 new clinical trials, a decrease from the 13 trials that launched in March 2026. Despite this dip in new openings, the city remains a significant hub for medical research, with a total of 1,063 clinical trials currently recruiting across 356 research facilities. These new studies span a variety of conditions and research types, offering diverse opportunities for participation.

Notable new trials from major sponsors and institutions include:

• Carelon Research is sponsoring NCT07525843, "A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study." This trial, aiming for 390 participants, seeks to determine if a 5-week online well-being program can help teenagers with congenital heart disease improve their ability to manage stress.
• Children's Hospital Medical Center, Cincinnati is leading NCT07512622, "Asthma Ctrl SMART Trial." This study, designed for 389 participants, will examine the effectiveness of an mHealth intervention called Asthma Ctrl in improving adherence to daily inhaled corticosteroids among adolescents with asthma.
• The Jaeb Center for Health Research is initiating NCT07518134, "A Study of Uveitis in Children <18 Years of Age." This observational study, targeting 300 participants, aims to collect data on the clinical features and treatments for uveitis in children.
• Eccogene is launching a Phase 2 study, NCT07505303, "MIST (Metabolic Intervention With Semaglutide and THR-β Therapy) Trial." This trial, with 160 participants, will evaluate the effect of oral ECC4703 on body weight reduction and liver fat content, particularly relevant for adult obesity.
• The National Institute of Allergy and Infectious Diseases (NIAID) is sponsoring a Phase 2 study, NCT07549503, "Early Signals of the Transition From Immune Quiescence to Activation in the Liver Allograft Microenvironment and in the Circulation." This longitudinal study, involving 100 participants, aims to determine the efficacy of a 50 percent immunosuppression reduction in liver transplant recipients.
• AstraZeneca is conducting a Phase 2 study, NCT07525375, "A Phase II Study to Investigate Lung Function With 2 Different Doses of Inhaled Glycopyrronium Taken With BFF Compared to BFF in Participants of 4 to Less Than 12 Years of Age With Asthma." This trial, for 69 participants, will evaluate the effect of different doses of inhaled glycopyrronium on lung function in children with asthma.

New trials this month are exploring conditions such as adolescent congenital heart disease, adult obesity, various forms of asthma, breast cancer, epilepsy, and liver transplant. Behavioral and procedure-based trials each account for 2 of the new studies, alongside drug and combination product trials.

Opportunities for Healthy Volunteers

For individuals without a specific medical condition, there are valuable opportunities to contribute to medical research. This month, 1 of the 8 new trials is actively seeking healthy volunteers. Overall, Cincinnati has 87 clinical trials currently recruiting healthy participants, providing numerous avenues for those interested in supporting medical advancements.

Cincinnati's Leading Research Institutions

Cincinnati is home to several prominent research institutions that consistently conduct a high volume of clinical trials. These facilities are key destinations for individuals seeking to participate in medical research:

• Cincinnati Children's Hospital Medical Center (257 trials)
• University of Cincinnati (109 trials)
• University of Cincinnati Medical Center (62 trials)
• University of Cincinnati Cancer Center-UC Medical Center (58 trials)
• Good Samaritan Hospital - Cincinnati (48 trials)
• Bethesda North Hospital (44 trials)
• The Christ Hospital (37 trials)
• TriHealth Cancer Institute-Anderson (37 trials)
• TriHealth Cancer Institute-Westside (37 trials)
• Cincinnati Children's Hospital (35 trials)
• Research Site (28 trials)
• Oncology Hematology Care Inc-Kenwood (28 trials)

These institutions offer a broad spectrum of research, from pediatric health at Cincinnati Children's Hospital Medical Center to oncology at the University of Cincinnati Cancer Center and TriHealth Cancer Institute, and general medical research across the University of Cincinnati and various hospital systems.

Conditions with Impending Deadlines

Patients managing certain health conditions also face impending deadlines to join research, as several trials are closing soon. Conditions with trials concluding within the next 90 days include:

• Advanced solid tumor (3 trials)
• Idiopathic hypersomnia (3 trials)
• Heart failure (2 trials)
• Migraine (2 trials)
• Epilepsy (2 trials)
• Obesity (2 trials)
• Ambulatory heart failure, NYHA Class IV (1 trial)
• Asthma (1 trial)
• Acute kidney injury (AKI) (1 trial)
• Aortic valve insufficiency (1 trial)

Broadening Your Search: Nearby Ohio Options

While Cincinnati offers a robust array of clinical trial opportunities, individuals may also find options in other communities within Ohio. Cities with active trials include Cleveland (9 trials), Columbus (7 trials), Akron (2 trials), Youngstown (2 trials), Canal Winchester (1 trial), Canfield (1 trial), Canton (1 trial), and Bay Village (1 trial).

Who Can Participate

Participation in clinical trials is open to a diverse range of individuals. Of the 8 new trials launched this month, 5 include children, and 3 include older adults, ensuring that various age groups have opportunities to contribute to medical science. Academic institutions like the University of Cincinnati and Cincinnati Children's Hospital Medical Center, along with industry sponsors such as AstraZeneca and Eccogene, are driving significant research efforts in the area.

As we move further into spring, Cincinnati's research community will continue to advance medical knowledge through these diverse studies, offering residents numerous ways to engage with cutting-edge healthcare innovation.