The BRIDGE Pain Study

Part of paid clinical trials in Cincinnati, Ohio.

Sponsor
Children's Hospital Medical Center, Cincinnati
Study ID
NCT07602595
Status
Recruiting
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Conditions

  • Chronic Pain
  • Fibromyalgia
  • Juvenile Idiopathic Arthritis (JIA)
  • Lupus
  • Musculoskeletal Pain
  • Pectus Excavatum
  • Scoliosis

Eligibility Criteria

Sex
ALL
Age
14 Years - 26 Years
Healthy Volunteers
Not accepted

Interventions

  • Not applicable- observational study — OTHER
    This is an observational study. No intervention is present.

Study Details

The purpose of the study is to discover at least two distinct Musculoskeletal pain subtypes. These types are caused by different brain-and-immune system signals that affect how the body feels pain, and they are also shaped by a person's biology, psychology, and social environment. Aim 1. We want to sort adolescents and young adults with long lasting muscle and bone pain into two different groups. To do this, we will look at participants' childhood medical histories, past treatments, when their pain started, the sex they were assigned at birth, what their pain feels like now, tests of how their body senses pain, and immune system markers found in their blood. We think we will find at least two different types of chronic pain groups, plus one group of patients who had a higher risk for pain (because of a rheumatic disease or past surgery) but never developed long term pain. Aim 2. We want to find out if certain patterns of inflammation in the body change how nerve cells react to pain. Aim 3: We want to understand how different biological, psychological, and social factors are connected to the chronic pain groups we identified. We think we will find certain mental, behavioral, and social risks-as well as protective factors-that help explain why some people develop long-lasting pain and others do not. We expect these factors to play different roles in each pain group, including the group that does not develop chronic pain.

Key Dates

Start date
Aug 31, 2026
Status verified
May 2026
Primary completion
Aug 31, 2029
Completion
Aug 31, 2029

Study Design

Enrollment
600 participants (estimated)

Arms

  • Arm: Primary musculoskeletal pain disorders
    localized or widespread MSK pain
  • Arm: Inflammatory/autoimmune rheumatic diseases
    juvenile idiopathic arthritis (JIA) and childhood-onset systemic lupus erythematosus (cSLE)
  • Arm: Major MSK surgeries
    scoliosis and pectus excavatum repair

Primary Outcome Measure

Conditioned Pain Modulation (CPM) Profile (Pressure) [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Cincinnati Children's HospitalCincinnatiOhio45211
Megan Kirschman
[email protected]
5136361846

Find similar trials in Cincinnati, OH

By condition
Lupus (SLE)
By specialty
RheumatologyAutoimmune disease
By research site
Cincinnati Children's Hospital· Cincinnati, OH

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