As of June 2026, 276 paid clinical trials are recruiting in Sioux Falls, South Dakota. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Sioux Falls offers studies at sites including Sanford USD Medical Center - Sioux Falls for conditions such as Breast Cancer, Ovarian Cancer, Endometrial Cancer, Heart Failure. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Sioux Falls has approximately 276 recruiting research studies across a wide range of therapeutic areas. South Dakota hosts a diverse network of universities, academic medical centers, and community hospitals that run clinical trials across oncology, cardiology, neurology, and many other therapeutic areas.
Researchers run research studies in Sioux Falls, SD at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Sanford USD Medical Center - Sioux Falls | Stage IV Lung Cancer AJCC v8, Malignant Solid Neoplasm, Stage IIIB Lung Cancer AJCC v8 | 98 |
| Sanford Cancer Center Oncology Clinic | Stage IV Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8 | 70 |
| Avera Cancer Institute | Breast Cancer, Endometrial Cancer, Ovarian Cancer | 50 |
| Sanford Cancer Center | Carcinoma, Non-Small Cell Lung, Colo-rectal Cancer, Colon Cancer | 18 |
| Sanford Health | Pregnancy, 1p36 Deletion Syndrome, 4p Deletion Syndrome, Non-Wolf-Hirschhorn Syndrome | 16 |
| Circle Clinical Research | Obesity or Overweight, Atherosclerotic Cardiovascular Disease (ASCVD), Depressive Disorder, Major | 6 |
| Avera Research Institute | Atrial Fibrillation, Developmental Delay, Idiopathic Pulmonary Fibrosis | 5 |
| Avera Research Institute - Sioux Falls | Alcohol Use Disorder, COVID-19, Migraine | 5 |
| North Central Heart | Heart Failure, Acute Limb Ischemia, Aortic Valve Disease | 5 |
| Avera Cancer Institute- Research | Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostate Cancer Metastatic, Prostatic Neoplasms | 5 |
| Avera Medical Group | Carcinoma, Non-Small-Cell Lung, Chronic Graft Versus Host Disease, Chronic Lymphocytic Leukemia | 3 |
| Sanford USD Medical Center | Carcinoma, Non-Small Cell Lung, Cutaneous Squamous Cell Cancer, Early Breast Cancer | 3 |
| Vance Thompson Vision | Astigmatism, Blepharoplasty, Cataract | 3 |
| Avera McKennan Hospital & University Health Center | COVID-19, Migraine | 2 |
| Avera Medical Group Pediatrics - Dawley Farm | Migraine | 2 |
| Ophthalmology Ltd | Macular Edema Secondary to Inflammation | 2 |
| Ophthalmology Ltd. | Epiretinal Membrane, Neovascular Age-related Macular Degeneration | 2 |
| Orthopedic Institute | Avascular Necrosis, Osteoarthritis Shoulder, Post-traumatic Arthrosis of Other Joints, Shoulder Region | 2 |
| Sanford Oncology Clinic and Pharmacy | Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostate Cancer | 2 |
| Sanford Research | Acute Myocardial Infarction (AMI), Cardiovascular Risk, T1D | 2 |
| Vance Thompson Vision Clinic, Prof. LLC | Dry Eye, Dry Eye Disease (DED) | 2 |
| Avera Cancer Institute - Sioux Falls | Epithelial Ovarian Cancer, Fallopian Tube Cancer, Neoadjuvant | 2 |
| GSK Investigational Site | Colonic Neoplasms, Neoplasms, Colon | 1 |
| Sanford Health_Sioux Falls | Heart Failure | 1 |
| Avera Cancer | Scleroderma, Diffuse | 1 |
Recruiting trials in Sioux Falls grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Clinical trials in South Dakota are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. South Dakota research additionally follows state public health department oversight and any applicable state privacy statutes.
Hipa.ai aggregates every recruiting study in Sioux Falls from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
There are approximately 276 recruiting clinical trials in Sioux Falls, South Dakota listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in Sioux Falls compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in Sioux Falls include Breast Cancer (12), Ovarian Cancer (9), Endometrial Cancer (8), Heart Failure (8), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Sioux Falls on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in Sioux Falls include Sanford USD Medical Center - Sioux Falls, Sanford Cancer Center Oncology Clinic, Avera Cancer Institute, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in Sioux Falls are Cancer & tumors (175), Cardiovascular (14), Eye & vision (9). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.