A Longitudinal Multi-Center Molecular Biomarker Discovery Registry for Patients With Hematologic Malignancies

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
Tempus AI
Study ID
NCT07154823
Status
Recruiting
Apply to this trial

Conditions

  • Acute Myeloid Leukaemia (AML)
  • Follicular Lymphoma ( FL)

Eligibility Criteria

Sex
ALL
Age
0 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • None - Observational Study — OTHER
    There are no interventions in this observational study.

Study Details

The TEMPUS AQUARIUS Study is a non-interventional, longitudinal observational study focused on hematological malignancies. It will collect rich molecular (multi-omic) and clinical data from patient cohorts through serial blood draws and the acquisition of leftover tissue and/or bone marrow aspirates during their routine therapy and disease monitoring. The primary goal is to understand the association between biomarkers and real-world clinical outcomes in these patient populations.

Key Dates

Start date
Jan 27, 2026
Status verified
Mar 2026
Primary completion
Nov 30, 2034
Completion
Nov 30, 2035

Study Design

Enrollment
550 participants (estimated)

Arms

  • Arm: Cohort 001: Newly Diagnosed Acute Myeloid Leukemia (AML)
    Newly diagnosed patients with a primary or secondary diagnosis of Acute Myeloid Leukemia (AML)
  • Arm: Cohort 002: Folicular Lymphoma
    Cohort 002 contains four subgroups of Follicular Lymphoma (FL): A: Newly Diagnosed FL on Active Observation; B: Newly Diagnosed High Risk FL; C: Relapsed / Refractory High Risk POD24 FL; D: Transformed FL

Primary Outcome Measure

To assess biomarker landscape in the progression as well as baseline biospecimen samples and correlate with with real-world outcomes across multiple hematologic indications. [ Time Frame: 5 years ]

Central Contacts

Locations (5)

FacilityCityStateZIPSite coordinators
The Center for Cancer and Blood DisordersBethesdaMaryland20817
Kosunique Jenkins
[email protected]
301-571-0019
Shreya Desai (PRINCIPAL_INVESTIGATOR)
Cancer Care Specialists of RenoRenoNevada89511
Layla Quinonez
[email protected]
775-329-0222
Juan Adolfo Cattoni III (PRINCIPAL_INVESTIGATOR)
Taylor Cancer Research CenterMaumeeOhio43537
Jennifer Martinez
[email protected]
419-479-5605
John Nemunaitis (PRINCIPAL_INVESTIGATOR)
Cancer Care Associates of YorkYorkPennsylvania17403
Clarissa Vega
[email protected]
717-741-9229
Jackson Gao (PRINCIPAL_INVESTIGATOR)
Avera Cancer InstitueSioux FallsSouth Dakota57105
Coordinator Contacts
[email protected]
Waqas Jehangir (PRINCIPAL_INVESTIGATOR)

Find similar trials in Bethesda, MD

By research site
The Center for Cancer and Blood Disorders· Bethesda, MDCancer Care Specialists of Reno· Reno, NVTaylor Cancer Research Center· Maumee, OHCancer Care Associates of York· York, PAAvera Cancer Institue· Sioux Falls, SD

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