Paid Clinical Trials in South Carolina

South Carolina has 1,276 paid clinical trials enrolling now across cities including Charleston, Greenville and Columbia. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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1,276 clinical trials

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Improving the HIV Care Continuum With mHealth Technology

for HIV - Human Immunodeficiency Virus

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 16 - 25

Code: NCT07631104·Not Yet Recruiting

Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress: the Lift RCT

for Critical Illness

3 locations incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07634419·Not Yet Recruiting

A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis

for Myasthenia Gravis, Generalized

9 locations incl. Boca Raton

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 80

Code: NCT07501702·Phase 2·Recruiting

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A Study to Assess the Safety, Tolerability and Efficacy of ION775

for Hypertriglyceridemia

8 locations incl. Lincoln

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07604974·Phase 2·Recruiting

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A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versus Standard of Care in Participants With Active Systemic Sclerosis

for Systemic Sclerosis

Drug: BMS-986353

16 locations incl. Scottsdale

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 16+

Code: NCT07335562·Phase 3·Recruiting

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Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events

for Obesity

11 locations incl. Walnut Creek

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07607587·Phase 1·Not Yet Recruiting

A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.

for Pneumococcal Disease

58 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 42 Days - 211 Days·Accepts healthy volunteers

Code: NCT07629440·Phase 3·Recruiting

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A Phase 1 Study of the Safety and Tolerability of CTX-10726

for Gastroesophageal Cancer (GC)

Drug: CTX-10726

5 locations incl. Boston

Sponsor: Compass Therapeutics

Sex: All·Age: 18+

Code: NCT07419841·Phase 1·Recruiting

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Clareon TruPlus Study

for Aphakia

5 locations incl. Phoenix

Sponsor: Alcon Research

Sex: All·Age: 22+

Code: NCT07502456·Recruiting

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Mindful Walking Neural Correlates of Executive Function in SC Older Adults at Risk of Dementias

for Older Adults With Elevated Dementia Risk

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT07638046·Phase 2·Recruiting

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A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

for Obesity

Drug: Semaglutide

99 locations incl. Birmingham

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07564414·Phase 3·Recruiting

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Phase 3 Study of LUM-201 in Children With Growth Hormone Deficiency

for Growth Hormone Deficiency (GHD)

26 locations incl. Birmingham

Sponsor: Lumos Pharma

Sex: All·Age: 3 - 11

Code: NCT06948214·Phase 3·Recruiting

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Evaluation of a Patient Decision Aid for Emergency Department Initiated Buprenorphine

for Opioid Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07278518·Recruiting

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A Study to Investigate the Effects of Cleminorexton Compared With Placebo in the Treatment of Participants With Central Disorders of Hypersomnolence

for Narcolepsy Type 1

2 locations incl. Huntersville

Sponsor: Centessa Pharmaceuticals (UK) Limited

Sex: All·Age: 18 - 70

Code: NCT07598708·Phase 2, Phase 3·Recruiting

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Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe

for Stroke

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 18+

Code: NCT07608588·Recruiting

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Pivotal Study of the SUpira System in Patients Undergoing High-Risk Percutaneous COronaRy InTervention (HRPCI)

for Coronary Artery Disease

14 locations incl. Sacramento

Sponsor: Supira Medical

Sex: All·Age: 18 - 90

Code: NCT07296744·Recruiting

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A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

for Obesity

Drug: NNC0487-0111

202 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07567001·Phase 3·Not Yet Recruiting

A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)

for Overweight

48 locations incl. Chandler

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07575932·Phase 2·Recruiting

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A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

for Major Depressive Disorder

27 locations incl. Gilbert

Sponsor: Definium Therapeutics US, Inc.

Sex: All·Age: 18 - 74

Code: NCT07592689·Phase 3·Recruiting

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Exoskeleton for Balance

for Stroke

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21+

Code: NCT07356011·Recruiting

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A Study to Identify and Characterize Patients With Type 2 Diabetes Mellitus for Possible Participation in Ongoing or Future Type 2 Diabetes Mellitus Clinical Studies

for Type 2 Diabetes

6 locations incl. Lincoln

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07606066·Recruiting

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Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

for Glioblastoma (GBM)

12 locations incl. Springdale

Sponsor: Black Diamond Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07326566·Phase 2·Recruiting

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A Non-inferiority Pharmacokinetic and Safety/Tolerability Study of Two Different Doses of Weekly SC Alpha1-PI 15% Compared With Corresponding Standard IV Alpha1-PI in Participants With Alpha1-Antitrypsin Deficiency (AATD)

for Alpha 1 Antitrypsin Deficiency

10 locations incl. Birmingham

Sponsor: Grifols Therapeutics LLC

Sex: All·Age: 18 - 80

Code: NCT07555483·Phase 3·Recruiting

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AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

for Obesity

Drug: NNC0487-0111

20 locations incl. Gilbert

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07571109·Phase 3·Recruiting

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Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors

for Squamous Cell Carcinoma Head and Neck Cancer (HNSCC)

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07149207·Phase 2·Recruiting

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A Study to Learn About the Safety of an Expanded Pneumococcal Vaccine in Healthy Infants

for Pneumococcal Disease

9 locations incl. Estero

Sponsor: Pfizer

Sex: All·Age: 42 Days - 98 Days·Accepts healthy volunteers

Code: NCT07573462·Phase 3·Recruiting

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AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)

for Metastatic Castration-resistant Prostate Cancer

24 locations incl. Dothan

Sponsor: AstraZeneca

Sex: Male·Age: 18+

Code: NCT07611110·Phase 3·Recruiting

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Implementation Facilitation of Exercise is Medicine Greenville

for Physical Inactivity

1 location in Greenville

Sponsor: University of South Carolina

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07340580·Not Yet Recruiting

Efficacy of Center-based Childcare to Mitigate Unhealthy Weight Gain in Preschoolers From Low-income Households During the Summer

for Obesity & Overweight

1 location in Columbia

Sponsor: University of South Carolina

Sex: All·Age: 3 - 5·Accepts healthy volunteers

Code: NCT07583459·Recruiting

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Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD

for Rhinovirus Infection

14 locations incl. Tempe

Sponsor: Altesa Biosciences, Inc.

Sex: All·Age: 40 - 85

Code: NCT07610395·Phase 2·Recruiting

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Pivotal Trial to Evaluate the Safety and Effectiveness of the P&F TricValve® Transcatheter Bicaval Valve System

for Tricuspid Valve Disease

35 locations incl. Birmingham

Sponsor: P+F Products + Features USA Inc.

Sex: All·Age: 18 - 85

Code: NCT06458907·Not Yet Recruiting

Pilot of Mailing Buprenorphine

for Opioid Use Disorder

2 locations incl. Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07421102·EARLY_Phase 1·Recruiting

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ColoSeal™ ICD System Anastomotic Protection Pivotal Study

for Rectal Cancer Surgery

2 locations incl. Charleston

Sponsor: Averto Medical, Inc.

Sex: All·Age: 22 - 75

Code: NCT07429110·Not Yet Recruiting

A Pragmatic Clinical Trial of the WE BEAT Well-Being Education Program in Adolescent Congenital Heart Disease: WE BEAT CHD Study

for Patient-Reported Outcome Measures (PROMs)

14 locations incl. Stanford

Sponsor: Carelon Research

Sex: All·Age: 12 - 17

Code: NCT07525843·Recruiting

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BOND: Direct Breastfeeding to Enhance Maternal and Infant Health in Congenital Heart Disease

for Congenital Heart Disease (CHD)

8 locations incl. Phoenix

Sponsor: Carelon Research

Sex: All·Age: 18+

Code: NCT07582848·Not Yet Recruiting

Prenatally-initiated Psychological Intervention for Mothers of Infants With Congenital Heart Disease (CHD)

for Congenital Heart Disease (CHD)

17 locations incl. Phoenix

Sponsor: Carelon Research

Sex: All·Age: 18+

Code: NCT07582861·Not Yet Recruiting

Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine

for Tobacco-flavored EC

1 location in Greenville

Sponsor: Prisma Health-Upstate

Sex: All·Age: 21+

Code: NCT07202039·Recruiting

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Open-Label Safety Study of AXS-14 in Subjects With Fibromyalgia

for Fibromyalgia

8 locations incl. Santa Ana

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07637162·Phase 3·Enrolling By Invitation

Sex Differences in Neurobehavioral Response to THC

for Cannabis Use Disorder

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 21 - 45

Code: NCT07225777·Phase 2·Recruiting

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Direct vs Standard SLT for Glaucoma: A Noninferiority Trial

for Open-angle Glaucoma (OAG)

1 location in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07408154·Recruiting

Apply to this trial