Sex Differences in Neurobehavioral Response to THC

Part of paid clinical trials in Charleston, South Carolina.

Sponsor
Medical University of South Carolina
Study ID
NCT07225777
Phase
PHASE2
Status
Recruiting
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Conditions

  • Cannabis Use Disorder

Eligibility Criteria

Sex
ALL
Age
21 Years - 45 Years
Healthy Volunteers
Not accepted

Interventions

  • Dronabinol — DRUG
    Oral dronabinol capsules (40 mg)
  • Placebo — DRUG
    Matched placebo capsules

Study Details

This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).

Key Dates

Start date
Apr 27, 2026
Status verified
May 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Other: Males
  • Other: Females

Primary Outcome Measure

Nucleus accumbens glutamate [ Time Frame: 2 hours post-dose ]

Locations (1)

FacilityCityStateZIPSite coordinators
Medical University of South CarolinaCharlestonSouth Carolina29403
Erin Martin, Ph.D.
[email protected]
843-876-3528

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Medical University of South Carolina· Charleston, SC

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