A Study to Assess the Safety, Tolerability and Efficacy of ION775

Part of paid clinical trials in Lincoln, California.

Sponsor
Ionis Pharmaceuticals, Inc.
Study ID
NCT07604974
Phase
PHASE2
Status
Recruiting
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Conditions

  • Hypertriglyceridemia
  • Severe Hypertriglyceridemia

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • ION775 — DRUG
    ION775 will be administered by SC injection.

Study Details

The main objective of this study is to evaluate the effect of ION775 on fasting triglyceride (TG) levels in participants with hypertriglyceridemia (HTG) and severe hypertriglyceridemia (sHTG).

Key Dates

Start date
May 31, 2026
Status verified
May 2026
Primary completion
Sep 30, 2027
Completion
Mar 31, 2028

Study Design

Enrollment
72 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: ION775: Cohot A
    Participants will be randomized to receive ION775 by subcutaneous (SC) injection.
  • Experimental: ION775: Cohot B
    Participants will be randomized to receive ION775 by SC injection.
  • Experimental: ION775: Cohot C
    Participants will be randomized to receive ION775 by SC injection.

Primary Outcome Measure

Percent Change From Baseline in Fasting Triglyceride (TG) [ Time Frame: Baseline, Month 6 ]

Central Contacts

Locations (8)

FacilityCityStateZIPSite coordinators
Ionis Investigative SiteLincolnCalifornia95648-
Ionis Investigative SiteMiamiFlorida33184-
Ionis Investigative SiteMiramarFlorida33027-
Ionis Investigative SiteFlintMichigan48504-
Ionis Investigative SiteMunroe FallsOhio44262-
Ionis Investigative SiteLittle RiverSouth Carolina29566-
Ionis Investigative SiteLampasasTexas76550-
Ionis Investigative SiteSan AntonioTexas78209-

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