Paid Clinical Trials in Roanoke, VA
As of June 2026, 168 paid clinical trials are recruiting in Roanoke, Virginia. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Roanoke offers studies at sites including Carilion Clinic for conditions such as Breast Cancer, Heart Failure, Ulcerative Colitis, Breast Neoplasms. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Roanoke
Trials by drug in Roanoke
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167 clinical trials
↓ Download CSVA Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk
Generalized and Domain-Specific Episodic Thinking for Smoking Cessation
Pivotal Trial to Evaluate the Safety and Effectiveness of the P&F TricValve® Transcatheter Bicaval Valve System
Pectoral Block in Breast Reduction for Pain Control
Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer
Kamuvudine-9 (K9) in Diabetic Macular Edema
A Study of Brenipatide in Participants With Opioid Use Disorder
Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
Study of AGN-151607-DP to Assess Adverse Events and Change in Disease Activity in Adult Participants Undergoing Open Abdominal Ventral Hernia Repair
A Study to Assess A Change in Disease Activity and Adverse Events of Intravenous Etentamig and Daratumumab (Etentamig+D) Compared to Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Adult Participants With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Antibody
Symbiotic-Lung-04: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Extensive-Stage Small Cell Lung Cancer
A Study of Solbinsiran (LY3561774) in Participants With Severe Hypertriglyceridemia
Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing
Efficacy of a Topical Palmitated Formulation of Capsaicin (Capsadyn®) In the Treatment of Diabetic Neuropathic Foot Pain
REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
Low-Intensity Focused Ultrasound Neuromodulation for Epilepsy
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Assessing the Impact of Muvalaplin on Major Cardiovascular Events in Adults With Elevated Lipoprotein(a)
A Study of Pasritamig Versus Placebo in Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)
A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations
Effects of Tax Proposals and Cigarette Availability on Tobacco Purchasing
Rademikibart Add-on Treatment of an Acute COPD Exacerbation (Seabreeze STAT COPD)
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
About research studies in Roanoke
Roanoke has approximately 168 recruiting research studies across a wide range of therapeutic areas. Virginia hosts the University of Virginia Health System, VCU Health, and Inova Health System, running clinical trials across oncology, cardiology, and neuroscience.
Top Research Study Locations in Roanoke
Researchers run research studies in Roanoke, VA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Carilion Clinic | Focal Epilepsy, Heart Failure, Cardiovascular Diseases | 30 |
| Carilion Roanoke Memorial Hospital | Breast Cancer, Malignant Female Reproductive System Neoplasm, Pancreatic Neoplasm | 22 |
| Carilion Children's | B Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Malignant Solid Neoplasm | 15 |
| Blue Ridge Cancer Care | Gastric Cancer, Breast Cancer, Cancer of the Prostate | 13 |
| Fralin Biomedical Research Institute at VTC | Chronic Pain, Cigarette Smoking Behavior, Anxiety Disorder | 10 |
| Oncology and Hematology Associates of Southwest Virginia (BRCC) | Biliary Tract Cancer, Colorectal Cancer, Pancreatic Ductal Adenocarcinoma | 4 |
| Fralin Biomedical Research Institute | Development of LIFU for Clinical Purposes, Pain, Post Traumatic Stress Disorder | 3 |
| Gastroenterology Consultants of Southwest Virginia | Ulcerative Colitis, Metabolic Dysfunction-Associated Steatotic Liver Disease, Obesity or Overweight | 3 |
| Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care | Advanced Renal Cell Carcinoma, Advanced or Metastatic Renal Cell Carcinoma, Carcinoma, Renal Cell | 3 |
| Akero Clinical Study Site | MASH - Metabolic Dysfunction-Associated Steatohepatitis, MASH With Fibrosis, NASH - Nonalcoholic Steatohepatitis | 2 |
| Carilion Children's Tanglewood Center | Crohn's Disease, Crohn's Disease (CD), Ulcerative Colitis | 2 |
| Fairlawn Surgery Center | Dialysis; Complications, End Stage Renal Disease, Vascular Access Complication | 2 |
| Fralin Biomedical Research Institute at Virginia Tech Carilion | Cigarette Smoking, E-cigarette Use, Neurobehavioral Components of Reward and Loss Valuation | 2 |
| Gastroenterology Consultants of Southwest Virginia. | Crohn's Disease, Moderately to Severely Active Crohn Disease, Ulcerative Colitis | 2 |
| Oncology & Hematology Associates of Southwest Virginia Inc dba Blue Ridge Cancer Care | Breast Cancer, Breast Neoplasms, Colorectal Neoplasms | 2 |
| Oncology & Hematology Associates of Southwest Virginia, Inc. | Extensive-Stage Small Cell Lung Cancer, Melanoma | 2 |
| Professional Education and Research Institute | Diabetic Foot Ulcers (DFUs), Venous Leg Ulcers | 2 |
| Carilion Roanoke Memorial Hospital | Epithelial Ovarian Cancer, Fallopian Tube Cancer, Neoadjuvant | 2 |
| Oncology and Hematology Associates of Southwest Virginia | Follicular Lymphoma (FL), Hepatocellular Carcinoma | 2 |
| Vistar Eye Center | Diabetic Macular Edema, AMD, CNV | 2 |
| 89bio Clinical Study Site | Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis | 1 |
| Anthos Investigative | Atrial Fibrillation (AF) | 1 |
| Artiva Investigational | IIM, Idiopathic Inflammatory Myopathies (IIMs), Myositis | 1 |
| Blue Ridge Cancer Care (Oncology and Hematology Associates of Southwest Virginia) | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | 1 |
| Blue Ridge Cancer Care - Roanoke | Multiple Myeloma | 1 |
Active & Upcoming Studies in Roanoke (2026)
Recruiting trials in Roanoke grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (64 active studies)
- Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer · Phase 1, Phase 2 · Pfizer
- Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer · Phase 1, Phase 2 · Pfizer
Neurology & pain (11 active studies)
- Low-Intensity Focused Ultrasound Neuromodulation for Epilepsy · Carilion Clinic
- LIFU for Chronic Pain · Virginia Polytechnic Institute and State University
Cardiovascular (11 active studies)
Mental health & behavior (8 active studies)
- Effects of Tobacco Abuse Liability-dependent Taxes in the ETM · Virginia Polytechnic Institute and State University
- Generalized and Domain-Specific Episodic Thinking for Smoking Cessation · Virginia Polytechnic Institute and State University
Diabetes & metabolic (6 active studies)
- Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study · Phase 3 · Eli Lilly and Company
- Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity · Phase 3 · Amgen
Eye & vision (3 active studies)
- Kamuvudine-9 (K9) in Diabetic Macular Edema · Phase 1, Phase 2 · Dr. Bryan Strelow
- A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma · Phase 3 · AbbVie
Vaccines (1 active study)
- Outpatient Treatment With Anti-Coronavirus Immunoglobulin · Phase 3 · University of Minnesota
Pediatric (1 active study)
- The FBRI VTC Neuromotor Research Clinic · Virginia Polytechnic Institute and State University
Common conditions studied in Roanoke
- Breast Cancer (5 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Heart Failure (5 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Ulcerative Colitis (5 active studies). Ulcerative colitis trials examine biologic therapies, S1P receptor modulators, and oral small molecules for steroid-sparing remission.
- Breast Neoplasms (4 active studies). Recruiting Breast Neoplasms studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Cardiovascular Diseases (4 active studies). Recruiting Cardiovascular Diseases studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Prostate Cancer (4 active studies). Prostate cancer studies test next-generation hormone therapies, PARP inhibitors, and radioligand treatments for both localized and advanced disease.
Leading research sponsors in Roanoke
- Virginia Polytechnic Institute and State University
- Merck Sharp & Dohme LLC
- Children's Oncology Group
- National Cancer Institute (NCI)
- Carilion Clinic
Local regulations and guidelines
Clinical trials in Virginia are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Virginia research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Roanoke. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Roanoke
Hipa.ai aggregates every recruiting study in Roanoke from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Roanoke?
There are approximately 168 recruiting clinical trials in Roanoke, Virginia listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Roanoke pay participants?
Most recruiting trials in Roanoke compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Roanoke?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Roanoke?
The most common conditions under active study in Roanoke include Breast Cancer (5), Heart Failure (5), Ulcerative Colitis (5), Breast Neoplasms (4), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Roanoke?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Roanoke on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Roanoke?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Roanoke?
Recruiting research sites in Roanoke include Carilion Clinic, Carilion Roanoke Memorial Hospital, Carilion Children's, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Roanoke right now?
The largest active categories in Roanoke are Cancer & tumors (64), Neurology & pain (11), Cardiovascular (11). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.