AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.

Part of paid clinical trials in Tuscaloosa, Alabama.

Sponsor
Artiva Biotherapeutics, Inc.
Study ID
NCT06991114
Phase
PHASE2
Status
Recruiting
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Conditions

  • IIM
  • Idiopathic Inflammatory Myopathies (IIMs)
  • Myositis
  • Refractory Rheumatoid Arthritis (RA)
  • Rheumatoid Arthritis (RA
  • Scleroderma
  • Sjogren Syndrome
  • Sjogrens Disease
  • Systemic Sclerosis (SSc)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Allogeneic NK Cells — DRUG
    AlloNK, dosed after a conditioning regimen, combined with Rituximab.

Study Details

A Basket Trial of Refractory Rheumatoid Arthritis (RA), Sjögren's Disease (SjD), Idiopathic Inflammatory Myopathies (IIMs) and Systemic Sclerosis (SSc) subjects to evaluate the safety and efficacy of AlloNK, a non-genetically modified allogeneic NK cell, in combination with rituximab.

Key Dates

Start date
Jul 9, 2025
Status verified
May 2026
Primary completion
Jan 31, 2028
Completion
Jan 31, 2029

Study Design

Enrollment
90 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: AlloNK
    AlloNK, dosed after a conditioning regimen, combined with Rituximab.

Primary Outcome Measure

Safety [ Time Frame: From enrollment until the end of treatment at Week 104. ]

Central Contacts

Locations (31)

FacilityCityStateZIPSite coordinators
Artiva Investigational Site TuscaloosaTuscaloosaAlabama35406-
Artiva Investigational Site PhoenixPhoenixArizona85037-
Artiva Investigational Site TucsonTucsonArizona85748-
Artiva Investigational Site Chula VistaChula VistaCalifornia92108-
Artiva Investigational Site CovinaCovinaCalifornia91723-
Artiva Investigational Site Los AlamitosLos AlamitosCalifornia90720-
Artiva Investigational Site Los AngelesLos AngelesCalifornia90027-
Artiva Investigational Site Santa AnaSanta AnaCalifornia92706-
Artiva Investigational Site TustinTustinCalifornia92780-
Artiva Investigational Site JupiterJupiterFlorida33458-
Artiva Investigational Site MiamiMiamiFlorida33143-
Artiva Investigational Site PlantationPlantationFlorida33324-
Artiva Investigational Site GainesvilleGainesvilleGeorgia30501-
Artiva Investigational Site NorcrossNorcrossGeorgia30092-
Artiva Investigational Site WillowbrookWillowbrookIllinois60527-
Artiva Investigational Site IowaIowa CityIowa52242-
Artiva Investigational Site Iowa Great FallsGreat FallsMontana59405-
Artiva Investigational Site CharlotteCharlotteNorth Carolina28207-
Artiva Investigational Site CharlotteCharlotteNorth Carolina28625-
Artiva Investigational Site StatesvilleStatesvilleNorth Carolina27103-
Artiva Investigational Site CharlestonCharlestonSouth Carolina29407-
Artiva Investigational Site HixsonHixsonTennessee37343-
Artiva Investigational Site JacksonJacksonTennessee38305-
Artiva Investigational Site ArlingtonArlingtonTexas76012-
Artiva Investigational Site BellaireBellaireTexas77401-
Artiva Investigational Site IrvingIrvingTexas75061-
Artiva Investigational Site KatyKatyTexas77494-
Artiva Investigational Site MesquiteMesquiteTexas75150-
Artiva Investigational Site Red OakRed OakTexas75154-
Artiva Investigational Site WoodlandWoodlandTexas77382-
Artiva Investigational Site RoanokeRoanokeVirginia24016-

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Artiva Investigational· Tuscaloosa, ALArtiva Investigational· Phoenix, AZArtiva Investigational· Tucson, AZArtiva Investigational Site Chula Vista· Chula Vista, CAArtiva Investigational· Covina, CAArtiva Investigational Site Los Alamitos· Los Alamitos, CA

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