Clinical Trials at University of Pennsylvania

As of June 2026, 377 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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377 clinical trials at University of Pennsylvania

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UPenn Observational Research Repository on Neurodegenerative Disease

for Frontotemporal Degeneration(FTD)

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04715399·Recruiting

Apply to this trial

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

for Frontotemporal Lobar Degeneration (FTLD)

25 locations incl. Birmingham

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04363684·Recruiting

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[18F]Fluoropropyl-Trimethoprim ([18F]F-TMP) PET/CT Imaging to Evaluate Biodistribution and Kinetics in Human Subjects

for Bacterial Infections

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04263792·Phase 1·Recruiting

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Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging

for Healthy

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04275453·Phase 1, Phase 2·Recruiting

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Terumo Aortic Global Endovascular Registry

for Abdominal Aortic Aneurysm

17 locations incl. Long Beach

Sponsor: Vascutek Ltd.

Sex: All·Age: 18+

Code: NCT04246463·Recruiting

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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

51 locations incl. Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting

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Prophylactic Reinforcement of Ventral Abdominal Incisions Trial

for Open Midline Laparotomy

30 locations incl. Phoenix

Sponsor: C. R. Bard

Sex: All·Age: 18+

Code: NCT03911700·Recruiting

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A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

for Acute Myeloid Leukemia

Drug: Revumenib

22 locations incl. Duarte

Sponsor: Syndax Pharmaceuticals

Sex: All·Age: 30 Days+

Code: NCT04065399·Phase 1, Phase 2·Recruiting

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Study Assessing MTD, Safety, Tolerability, PK and Anti-tumor Effects of LNS8801alone and With Pembrolizumab

for Solid Tumor, Adult

10 locations incl. Los Angeles

Sponsor: Linnaeus Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT04130516·Phase 1, Phase 2·Recruiting

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Parkinson's Disease and Movement Disorders Clinical Database

for Parkinson Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04997642·Recruiting

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A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

for Treatment Resistant Depression

98 locations incl. Birmingham

Sponsor: LivaNova

Sex: All·Age: 18+

Code: NCT03887715·Recruiting

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Li-Fraumeni Syndrome/TP53 Biobank

for Li-Fraumeni Syndrome

2 locations incl. Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04367246·Recruiting

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A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

for PAH

Drug: Ralinepag

48 locations incl. Phoenix

Sponsor: United Therapeutics

Sex: All·Age: 18+

Code: NCT03683186·Phase 3·Enrolling By Invitation

Dynamic Neural Mechanisms of Audiovisual Speech Perception

for Speech Perception

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 21 - 65

Code: NCT04290130·Enrolling By Invitation

Cenobamate Open-Label Extension Study for YKP3089C025

for Primary Generalized Tonic Clonic Seizures in the Setting of Idiopathic Generalized Epilepsy

Drug: Cenobamate

16 locations incl. La Jolla

Sponsor: SK Life Science, Inc.

Sex: All·Age: 12+

Code: NCT03961568·Phase 3·Enrolling By Invitation

Phenotyping Genetic Risk for Type 2 Diabetes

for Diabetes Mellitus, Type 2

2 locations incl. Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 10 - 70·Accepts healthy volunteers

Code: NCT04024631·Recruiting

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Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study

for Lower Respiratory Tract Infection

49 locations incl. Duarte

Sponsor: Ansun Biopharma, Inc.

Sex: All·Age: All ages

Code: NCT03808922·Phase 3·Recruiting

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[18F] F-GLN by PET/CT in Breast Cancer

for Breast Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT03863457·Phase 1·Recruiting

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Safety Trial of Antimicrobial Therapy and Precision Radiation Therapy in Patients With Oligoprogressive Non-small Cell Lung Cancer

for Early Stage Non-Small Cell Lung Cancer

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT03546829·Phase 1·Recruiting

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Imaging Sex Differences in Smoking-Induced Pulmonary Inflammation

for Smoking, Cigarette

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT03721822·Phase 1·Recruiting

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Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

for Solid Tumors

65 locations incl. Tucson

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT03486873·Phase 3·Recruiting

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Longitudinal Early-onset Alzheimer's Disease Study Protocol

for Early Onset Alzheimer Disease

18 locations incl. Sun City

Sponsor: Indiana University

Sex: All·Age: 40 - 64·Accepts healthy volunteers

Code: NCT03507257·Recruiting

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Adoptive Cell Therapy Long-term Follow-up (LTFU) Study

for Neoplasms

13 locations incl. Atlanta

Sponsor: USWM CT, LLC

Sex: All·Age: All ages

Code: NCT03391778·Phase 1·Recruiting

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The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

for Functional Mitral Regurgitation

75 locations incl. Gilbert

Sponsor: Cardiac Dimensions, Inc.

Sex: All·Age: 18+

Code: NCT03142152·Recruiting

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Study of Immune Responses to Influenza Vaccination

for Influenza Vaccination

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03346772·Phase 4·Recruiting

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Neuroprognostication Bias: A Collaboration to Reduce the Impact of Self-fulfilling Prophecy in Cardiac ARrEst

for Cardiac Arrest

5 locations incl. San Francisco

Sponsor: Boston Medical Center

Sex: All·Age: 18 - 89

Code: NCT03261089·Recruiting

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Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

for Cryoglobulinemic Vasculitis (CV)

8 locations incl. Los Angeles

Sponsor: Peter Merkel

Sex: All·Age: 5+

Code: NCT03004326·Recruiting

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HoFH, the International Clinical Collaborators Registry

for Homozygous Familial Hypercholesterolemia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT04815005·Recruiting

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A Randomized Multicenter Study for Isolated Skin Vasculitis

for Primary Cutaneous Vasculitis

12 locations incl. Kansas City

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT02939573·Phase 2·Recruiting

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Transformative Research in Diabetic Nephropathy

for Diabetic Nephropathies

17 locations incl. Little Rock

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 100

Code: NCT02986984·Recruiting

Apply to this trial

The Myelin Disorders Biorepository Project

for Leukodystrophy

23 locations incl. Los Angeles

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT03047369·Recruiting

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VCRC Tissue Repository

for Aortitis

6 locations incl. Boston

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT02967068·Recruiting

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International Registry for Patients With Castleman Disease

for Castleman Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT02817997·Recruiting

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MEASuRE: Metreleptin Effectiveness And Safety Registry

for Generalised Lipodystrophy

16 locations incl. Birmingham

Sponsor: Amryt Pharma

Sex: All·Age: All ages

Code: NCT02325674·Recruiting

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PET Tau - Neurodegenerative Disease Imaging

for Neurodegenerative Disease

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT03143374·Phase 2, Phase 3·Recruiting

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Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma

for Anaplastic (Malignant) Meningioma

Drug: Bevacizumab

8 locations incl. Santa Monica

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT02847559·Phase 2·Recruiting

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CAR-T Long Term Follow Up (LTFU) Study

for Long Term Safety of Patients Receiving CAR-T in an Eligible Clinical Trial or Managed Access Program

44 locations incl. Phoenix

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 0 - 100

Code: NCT02445222·Phase 3·Recruiting

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Pulmonary Hypertension Association Registry

for Pulmonary Arterial Hypertension

52 locations incl. Phoenix

Sponsor: Pulmonary Hypertension Association, Inc.

Sex: All·Age: 0+

Code: NCT04071327·Recruiting

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Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

for Genetic Disease

33 locations incl. Birmingham

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Month - 100·Accepts healthy volunteers

Code: NCT02450851·Recruiting

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OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages

for Eosinophilic Gastrointestinal Disorders (EGIDs)

19 locations incl. Phoenix

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 3+

Code: NCT02523118·Recruiting

Apply to this trial