Study of Immune Responses to Influenza Vaccination

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
University of Pennsylvania
Study ID
NCT03346772
Phase
PHASE4
Status
Recruiting
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Conditions

  • Influenza Vaccination

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Influenza vaccination — BIOLOGICAL
    Adults will receive one intramuscular dose of seasonal quadrivalent inactivated influenza vaccine, as indicated for standard of care.

Study Details

Better understanding of the immune responses to influenza vaccination is needed in order to understand situations of poor vaccine response. Adults will receive influenza vaccination and then have peripheral blood drawn at pre-defined intervals in order to study the lymphocyte responses.

Key Dates

Start date
Oct 20, 2017
Status verified
Aug 2025
Primary completion
Jul 1, 2026
Completion
Jul 1, 2026

Study Design

Enrollment
75 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Influenza vaccination cohort
    Adults will receive one intramuscular dose of seasonal quadrivalent inactivated influenza vaccine, as indicated for standard of care.

Primary Outcome Measure

Influenza neutralizing antibody titers [ Time Frame: 21-42 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of PennsylvaniaPhiladelphiaPennsylvania19104
Sokratis Apostolidis, MD
[email protected]
267-584-6653
E. John Wherry, PhD (PRINCIPAL_INVESTIGATOR)

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