Phenotyping Genetic Risk for Type 2 Diabetes

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
University of Pennsylvania
Study ID
NCT04024631
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
10 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • 75g glucose beverage (Glucola, Trutol, or similar brand) — OTHER
    Subjects will present fasting to the study day and ingest the glucose beverage during the oral glucose tolerance test.
  • DXA, whole body — OTHER
    Subjects will undergo a whole body DXA scan for assessment of adiposity index and body fat distribution.

Study Details

This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.

Key Dates

Start date
Jun 17, 2019
Status verified
Aug 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
100 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Other: Phenotyping
    All participants will undergo a four-hour frequently sampled oral glucose tolerance test in which they will ingest a 75g glucose beverage (intervention) within five minutes and have samples collected at baseline and for four hours after. They will also undergo a whole body DXA (intervention) during the study day.

Primary Outcome Measure

Glucose response to an oral glucose load [ Time Frame: samples will be collected over four hours and these results will be used to calculate area under the curve ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Childrens Hospital of PhiladelphiaPhiladelphiaPennsylvania19104
Jessica R Wilson, MD, MS
[email protected]
215 898-3389
Esther Oyerinde
[email protected]
University of PennsylvaniaPhiladelphiaPennsylvania19104
Jessica R Wilson, MD, MS
[email protected]
215 898-3389
Esther Oyerinde
[email protected]

Find similar trials in Philadelphia, PA

By condition
Type 2 diabetes
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
Childrens Hospital of Philadelphia· Philadelphia, PAUniversity of Pennsylvania· Philadelphia, PA

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