Clinical Trials at University of Pennsylvania

As of June 2026, 377 paid clinical trials are recruiting at University of Pennsylvania, located at Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, phone (215) 898-8001 in Philadelphia, Pennsylvania. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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377 clinical trials at University of Pennsylvania

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Behavioral Relaxation Approaches for Insomnia in Pregnant Patients

for Sleep Initiation and Maintenance Disorders

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 18 - 55

Code: NCT05530863·Enrolling By Invitation

The ExTINGUISH Trial of Inebilizumab in NMDAR Encephalitis

for Autoimmune Encephalitis

Drug: Inebilizumab

35 locations incl. Birmingham

Sponsor: University of Utah

Sex: All·Age: 12+

Code: NCT04372615·Phase 2·Recruiting

Apply to this trial

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

for Colorectal Carcinoma

9 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05410977·Recruiting

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Long-Term Follow-up Study

for Lymphoma, Non-Hodgkin

31 locations incl. Birmingham

Sponsor: Caribou Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05332054·Enrolling By Invitation

Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

for Solid Tumors

17 locations incl. Duarte

Sponsor: ORIC Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05315700·Phase 1, Phase 2·Recruiting

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A Long-term Study for Participants Previously Treated With Ciltacabtagene Autoleucel

for Multiple Myeloma

28 locations incl. Phoenix

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05201781·Phase 4·Recruiting

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Longitudinal Assessment of Traumatic Microvascular Injury-2

for Traumatic Brain Injury

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05725993·Recruiting

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International REgistry of COnservative or Radical Treatment of Localized Kidney Tumors

for Kidney Cancer

7 locations incl. Los Angeles

Sponsor: Azienda Ospedaliero-Universitaria Careggi

Sex: All·Age: 18+

Code: NCT05363657·Recruiting

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Single and Multiple Dose Escalation of PHIN-214 in Child-Pugh A and B Liver Cirrhotics

for Cirrhosis, Liver

9 locations incl. Chandler

Sponsor: PharmaIN

Sex: All·Age: 18 - 75

Code: NCT05490888·Phase 1·Recruiting

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DISE: Phenotyping Obstruction Patterns

for Obstructive Sleep Apnea

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05050383·Recruiting

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Matching Perfusion and Metabolic Activity in HFpEF

for Heart Failure With Preserved Ejection Fraction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04913805·Phase 2·Recruiting

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CapTemY90 for Grade 2/3 NET Liver Metastases

for Neuroendocrine Tumor Grade 2

4 locations incl. La Jolla

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04339036·Phase 2·Recruiting

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Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults

for Influenza, Human

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05108818·Phase 4·Recruiting

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JAGUAR Trial: ObJective Analysis to GaUge EVAR Outcomes Through Randomization

for AAA

29 locations incl. Huntsville

Sponsor: Endologix

Sex: All·Age: 21+

Code: NCT05064540·Recruiting

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ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

for Bladder Carcinoma

33 locations incl. Birmingham

Sponsor: Guardant Health, Inc.

Sex: All·Age: 18+

Code: NCT05059444·Recruiting

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Study in Parkinson Disease of Exercise

for Parkinson Disease

24 locations incl. Birmingham

Sponsor: Northwestern University

Sex: All·Age: 40 - 80

Code: NCT04284436·Recruiting

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GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance

for Cystic Fibrosis

2 locations incl. Aurora

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04731272·Phase 2·Recruiting

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Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

for Liver Diseases

18 locations incl. Los Angeles

Sponsor: European Foundation for Study of Chronic Liver Failure

Sex: All·Age: 18 - 80

Code: NCT04613921·Recruiting

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CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting

for Cardiac Valve Disease

9 locations incl. Indianapolis

Sponsor: Corcym S.r.l

Sex: All·Age: All ages

Code: NCT05002543·Recruiting

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Long Term Follow up of the LTOG Cohort

for Lung Transplant Failure and Rejection

10 locations incl. Birmingham

Sponsor: University of Pennsylvania

Sex: All·Age: 13+

Code: NCT04787822·Enrolling By Invitation

Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer

for Breast Cancer

7 locations incl. Washington D.C.

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04841148·Phase 2·Recruiting

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A Study of Daratumumab and Dose-Adjusted EPOCH in Plasmablastic Lymphoma

for Plasmablastic Lymphoma

Drug: Daratumumab

8 locations incl. Miami

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT04139304·EARLY_Phase 1·Recruiting

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Handoffs and Transitions in Critical Care - Understanding Scalability

for Patient Handoff

5 locations incl. Baltimore

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04571749·Enrolling By Invitation

Abatacept for the Treatment of Giant Cell Arteritis

for Giant Cell Arteritis

5 locations incl. Rochester

Sponsor: University of Pennsylvania

Sex: All·Age: 50+

Code: NCT04474847·Phase 3·Recruiting

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Localizing Epileptic Networks Using MRI and iEEG

for Epilepsy

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04649008·EARLY_Phase 1·Recruiting

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Longitudinal Study for Relapsing Polychondritis

for Relapsing Polychondritis

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: All ages

Code: NCT04919538·Recruiting

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PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches

for Aneurysm

10 locations incl. Aurora

Sponsor: Vascutek Ltd.

Sex: All·Age: 18+

Code: NCT04545502·Recruiting

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BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)

for Advanced Malignancies

3 locations incl. Duarte

Sponsor: BioInvent International AB

Sex: All·Age: 18+

Code: NCT04752826·Phase 1, Phase 2·Recruiting

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Collection of Samples USOPTIVAL Study

for Colorectal Cancer (CRC)

16 locations incl. Chula Vista

Sponsor: Universal Diagnostics

Sex: All·Age: 45 - 84·Accepts healthy volunteers

Code: NCT04792684·Recruiting

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Parkinson's Foundation PD GENEration Genetic Registry

for Parkinson's Disease

54 locations incl. Birmingham

Sponsor: Parkinson's Foundation

Sex: All·Age: 18+

Code: NCT04994015·Recruiting

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Physiological Effects of ANGPTL3 Variants in Humans

for Hypocholesterolemia

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04234724·Recruiting

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Prospective 4D CTA of BAV Competence

for Bicuspid

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04645862·Recruiting

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Resuscitative TEE Collaborative Registry

for Cardiac Arrest

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04972526·Recruiting

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The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

for Supratentorial Hemorrhage

20 locations incl. Burbank

Sponsor: Integra LifeSciences Corporation

Sex: All·Age: 18+

Code: NCT04494295·Recruiting

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NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

for Aortic Dissection

31 locations incl. Birmingham

Sponsor: Endospan Ltd.

Sex: All·Age: 18+

Code: NCT04471909·Recruiting

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A Phase 1/2, Open-label, Safety and Dosing Study of Autologous CART Cells (Desmoglein 3 Chimeric Autoantibody Receptor T Cells [DSG3-CAART] or CD19-specific Chimeric Antigen Receptor T Cells [CABA-201]) in Subjects With Active, Pemphigus Vulgaris (RESET-PV)

for Pemphigus Vulgaris

13 locations incl. Redwood City

Sponsor: Cabaletta Bio

Sex: All·Age: 18+

Code: NCT04422912·Phase 1, Phase 2·Recruiting

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Pancreatic Cancer Early Detection Consortium

for Pancreas Cancer

45 locations incl. Phoenix

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04970056·Recruiting

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An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System

for Mitral Regurgitation

10 locations incl. Tucson

Sponsor: HighLife SAS

Sex: All·Age: 18+

Code: NCT04029337·Recruiting

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PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

for Parkinson Disease

30 locations incl. Birmingham

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT04477785·Recruiting

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HEALEY ALS Platform Trial - Master Protocol

for Amyotrophic Lateral Sclerosis

81 locations incl. Phoenix

Sponsor: Merit E. Cudkowicz, MD

Sex: All·Age: 18+

Code: NCT04297683·Phase 2, Phase 3·Recruiting

Apply to this trial