Matching Perfusion and Metabolic Activity in HFpEF

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
University of Pennsylvania
Study ID
NCT04913805
Phase
PHASE2
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Potassium Nitrate — DRUG
    Potassium Nitrate is the active intervention that may increase blood flow to exercising muscle
  • Potassium Nitrate + Propionyl-L-Carnitine + Nicotinamide Riboside — DRUG
    Potassium Nitrate + Propionyl-L-Carnitine + Nicotinamide Riboside will be used as a combination intervention to both increase blood flow (KNO3) and mitochondrial function (PLC + NR)
  • Potassium Chloride — OTHER
    Active control

Study Details

This study will test whether pharmacologic agents that increase perfusion \[Potassium Nitrate (KNO3)\], with and without additional supplements that may improve mitochondrial function \[Propionyl-L-Carnitine (PLC) and Nicotinamide Riboside (NR)\], improve submaximal exercise endurance and skeletal muscle oxidative phosphorylation capacity (SkM OxPhos) in participants with Heart Failure with Preserved Ejection Fraction (HFpEF).

Key Dates

Start date
Oct 11, 2021
Status verified
May 2026
Primary completion
May 1, 2027
Completion
May 1, 2027

Study Design

Enrollment
53 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Active Comparator: Potassium Nitrate
    Potassium Nitrate (KNO3) 6 mmol three times daily
  • Active Comparator: Potassium Nitrate + Propionyl-L-Carnitine + Nicotinamide Riboside
    Potassium Nitrate (KNO3) 6 mmol three times daily + Propionyl-L-Carnitine (PLC) 1000 mg twice daily + Nicotinamide Riboside (NR) 300 mg three times daily
  • Placebo Comparator: Potassium Chloride
    Potassium Chloride (KCl) 6 mmol three times daily

Primary Outcome Measure

Submaximal Exercise Endurance [ Time Frame: week 6 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of PennsylvaniaPhiladelphiaPennsylvania19104
Cassandra Demastus, NP
[email protected]
4432719022

Find similar trials in Philadelphia, PA

By condition
Heart failure
By specialty
CardiologyHeart disease
By research site
University of Pennsylvania· Philadelphia, PA

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