Localizing Epileptic Networks Using MRI and iEEG

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
University of Pennsylvania
Study ID
NCT04649008
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Epilepsy
  • Epilepsy Intractable
  • Epilepsy, Temporal Lobe

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • 3T Magnetic Resonance Imaging — DIAGNOSTIC_TEST
    Magnetic resonance imaging acquired at a field strength of 3 Tesla.
  • Intracranial electroencephalography recordings — DIAGNOSTIC_TEST
    Epilepsy patients may undergo implantation of intracranial electroencephalography (iEEG) electrodes for localization of epileptogenic foci, which also provide a means to record localized brain activity during memory or other tasks for research purposes.
  • 7T Magnetic Resonance Imaging — DIAGNOSTIC_TEST
    Magnetic resonance imaging acquired at a field strength of 7 Tesla.

Study Details

Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions.

Key Dates

Start date
Mar 1, 2021
Status verified
Feb 2026
Primary completion
Feb 28, 2027
Completion
Feb 28, 2027

Study Design

Enrollment
290 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Epilepsy patient volunteers
    Patients recruited for the study with intractable epilepsy who are anticipated to undergo epilepsy surgery

Primary Outcome Measure

Structure-function coupling [ Time Frame: Measure will be assessed upon collection of patient pre-implant MRI study and iEEG recordings, and control MRI ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of PennsylvaniaPhiladelphiaPennsylvania19104
Carolyn Wilkinson, BSN
[email protected]
215-746-4850

Find similar trials in Philadelphia, PA

By condition
Epilepsy
By specialty
NeurologyBrain disorders
By research site
University of Pennsylvania· Philadelphia, PA

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