Cardiology Clinical Trials in Philadelphia, PA

As of June 2026, 80 paid clinical trials are recruiting for Cardiology in Philadelphia, Pennsylvania. Cardiology trials investigate SGLT-2 inhibitors, myosin modulators, lipid-lowering therapies, anti-inflammatory agents, and device-based interventions across heart failure, hypertension, AFib, and coronary artery disease. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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80 clinical trials for Cardiology

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A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation

for Heart Failure

Drug: Ziltivekimab

41 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT06200207·Phase 3·Recruiting

Apply to this trial

Penn Medicine Healthy Heart

for Hypertension

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 35 - 80

Code: NCT06062394·Recruiting

Apply to this trial

Hypertension and Arrhythmias in CLL Patients Treated With BTK Inhibitors

for Chronic Lymphocytic Leukemia

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 22+

Code: NCT06211413·Enrolling By Invitation

Feasibility of Semaglutide in Advanced Lung Disease

for Obesity

Drug: Semaglutide

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 80

Code: NCT05746039·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

for Heart Failure

Drug: Finerenone

77 locations incl. Birmingham

Sponsor: Colorado Prevention Center

Sex: All·Age: 18+

Code: NCT06008197·Phase 3·Recruiting

Apply to this trial

BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

for Hypertension

70 locations incl. Scottsdale

Sponsor: Orchestra BioMed, Inc

Sex: All·Age: 18+

Code: NCT06059638·Recruiting

Apply to this trial

The Fourth Left Atrial Appendage Occlusion Study

for Atrial Fibrillation

51 locations incl. Birmingham

Sponsor: Hamilton Health Sciences Corporation

Sex: All·Age: 18+

Code: NCT05963698·Recruiting

Apply to this trial

The GORE VBX FORWARD Clinical Study: A Comparison of the GORE® VIABAHN® VBX Balloon Expandable Endoprosthesis to Bare Metal Stenting for Patients With Complex Iliac Occlusive Disease

for Aortoiliac Occlusive Disease

26 locations incl. Little Rock

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT05811364·Recruiting

Apply to this trial

CTSN Embolic Protection Trial

for Delirium

24 locations incl. North Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 60+

Code: NCT06027788·Recruiting

Apply to this trial

Left vs Left Randomized Clinical Trial

for Heart Failure

57 locations incl. Gilbert

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+

Code: NCT05650658·Recruiting

Apply to this trial

Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure

for Heart Failure

47 locations incl. Phoenix

Sponsor: Procyrion

Sex: All·Age: 21+

Code: NCT05677100·Recruiting

Apply to this trial

The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation

for Atrial Fibrillation

93 locations incl. Phoenix

Sponsor: Johns Hopkins University

Sex: All·Age: 22 - 85

Code: NCT05836987·Phase 3·Recruiting

Apply to this trial

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

for Heart Failure

20 locations incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 29 Days - 17

Code: NCT05714085·Phase 2, Phase 3·Recruiting

Apply to this trial

A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation

for Heart Failure

Drug: Ziltivekimab

184 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT05636176·Phase 3·Recruiting

Apply to this trial

Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women

for Heart Diseases

42 locations incl. Los Angeles

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18+

Code: NCT04124120·Recruiting

Apply to this trial

HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

for Heart Failure

6 locations incl. Sacramento

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT05873634·Recruiting

Apply to this trial

The Path to Optimal Black Maternal Heart Health: Comparing Two CVD Risk Reduction Interventions (Change of HEART)

for Pregnancy Related

1 location in Philadelphia

Sponsor: Temple University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05499507·Recruiting

Apply to this trial

Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-008)

for Pulmonary Arterial Hypertension

10 locations incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 1 - 17

Code: NCT05587712·Phase 2·Recruiting

Apply to this trial

DEFIANCE: RCT of ClotTriever System Versus Anticoagulation In Deep Vein Thrombosis

for Venous Thromboembolism

48 locations incl. Scottsdale

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT05701917·Recruiting

Apply to this trial

PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

for Critical Limb Ischemia

30 locations incl. La Jolla

Sponsor: LimFlow, Inc.

Sex: All·Age: 18 - 95

Code: NCT05313165·Recruiting

Apply to this trial

His-Bundle Corrective Pacing in Heart Failure

for Right Bundle-Branch Block

14 locations incl. Phoenix

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05265520·Recruiting

Apply to this trial

Continuation of the nuMoM2b Heart Health Study

for Cardiovascular Diseases

14 locations incl. Orange

Sponsor: RTI International

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05472597·Enrolling By Invitation

EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study

for Heart Failure

15 locations incl. Los Angeles

Sponsor: Berlin Heart, Inc

Sex: All·Age: Up to 21

Code: NCT05610787·Enrolling By Invitation

Assessment of CCM in HF With Higher Ejection Fraction

for Heart Failure

105 locations incl. Birmingham

Sponsor: Impulse Dynamics

Sex: All·Age: 18+

Code: NCT05064709·Recruiting

Apply to this trial

SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial

for Heart Failure With Preserved Ejection Fraction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT05138575·Phase 2·Recruiting

Apply to this trial

Perioperative Anticoagulant Use for Surgery Evaluation -Virtual Visit (PAUSE-Virtual)

for Atrial Fibrillation (AF)

4 locations incl. Evanston

Sponsor: McMaster University

Sex: All·Age: 18 - 100

Code: NCT06844227·Recruiting

Apply to this trial

Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs

for Interstitial Lung Disease

14 locations incl. Phoenix

Sponsor: Paragonix Technologies

Sex: All·Age: All ages

Code: NCT04930289·Enrolling By Invitation

Matching Perfusion and Metabolic Activity in HFpEF

for Heart Failure With Preserved Ejection Fraction

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04913805·Phase 2·Recruiting

Apply to this trial

Distal Evaluation of Functional Performance with Intravascular Sensors to Assess the Narrowing Effect: Guided Physiologic Stenting

for Coronary Artery Disease

40 locations incl. Birmingham

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT04451044·Enrolling By Invitation

Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

102 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting

Apply to this trial

Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

187 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting

Apply to this trial

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

51 locations incl. Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting

Apply to this trial

A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension

for PAH

Drug: Ralinepag

48 locations incl. Phoenix

Sponsor: United Therapeutics

Sex: All·Age: 18+

Code: NCT03683186·Phase 3·Enrolling By Invitation

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

for Functional Mitral Regurgitation

75 locations incl. Gilbert

Sponsor: Cardiac Dimensions, Inc.

Sex: All·Age: 18+

Code: NCT03142152·Recruiting

Apply to this trial

Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

for Heart Failure With Preserved Ejection Fraction

38 locations incl. Alexander City

Sponsor: Uppsala University

Sex: All·Age: 50 - 99

Code: NCT02901184·Phase 3·Recruiting

Apply to this trial

Pulmonary Hypertension Association Registry

for Pulmonary Arterial Hypertension

52 locations incl. Phoenix

Sponsor: Pulmonary Hypertension Association, Inc.

Sex: All·Age: 0+

Code: NCT04071327·Recruiting

Apply to this trial

Pediatric Pulmonary Hypertension Network (PPHNet) Informatics Registry

for Pulmonary Vascular Disease

13 locations incl. Palo Alto

Sponsor: New York Medical College

Sex: All·Age: 1 Day - 21

Code: NCT02249923·Recruiting

Apply to this trial

Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes

for Peripheral Arterial Disease

24 locations incl. Little Rock

Sponsor: Baylor Research Institute

Sex: All·Age: All ages

Code: NCT01904851·Recruiting

Apply to this trial

Product Surveillance Registry

for Cardiac Rhythm Disorders

134 locations incl. Birmingham

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT01524276·Recruiting

Apply to this trial

Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

for Arrhythmia

113 locations incl. Birmingham

Sponsor: Medtronic

Sex: All·Age: All ages

Code: NCT00271180·Recruiting

Apply to this trial

Conditions in Cardiology (Philadelphia, PA)

Heart failure· 26 Cardiovascular disease (general)· 15 Pulmonary hypertension· 14 Atrial fibrillation· 12 Hypertension (high blood pressure)· 11 Coronary artery disease· 6 Peripheral artery disease· 4 Congenital heart disease· 2 Myocardial infarction (heart attack)· 1 Venous thromboembolism· 1