Paid Clinical Trials in Pennsylvania

Pennsylvania has 3,663 paid clinical trials enrolling now across cities including Philadelphia, Pittsburgh and Hershey. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Pennsylvania include Penn Medicine, Children's Hospital of Philadelphia and UPMC, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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3,663 clinical trials

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Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)

for Gastroesophageal Junction

8 locations incl. Tucson

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06469944·Phase 1, Phase 2·Recruiting

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Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis

for FAP

1 location in Philadelphia

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06578637·Recruiting

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A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

for Solid Tumor

19 locations incl. Little Rock

Sponsor: NiKang Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06586957·Phase 1·Recruiting

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A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

for Geographic Atrophy

45 locations incl. Tucson

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 60+

Code: NCT06635148·Phase 2·Recruiting

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A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

for Cystic Fibrosis

68 locations incl. Birmingham

Sponsor: Nicole Hamblett

Sex: All·Age: 12+

Code: NCT06504589·Recruiting

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Use of Nicotine Pouches Among Daily Smokers

for Tobacco Dependence

2 locations incl. Hershey

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 21 - 70·Accepts healthy volunteers

Code: NCT06043362·Recruiting

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Efficacy Of Sodium Glucose Transporter Inhibitor (SGLT2I) In Adult Patients With Congenital Heart Disease

for Adult Congenital Heart Disease

3 locations incl. Pittsburgh

Sponsor: Anita Saraf

Sex: All·Age: 18+

Code: NCT06260059·Phase 4·Recruiting

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Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients

for Non Small Cell Lung Cancer

Drug: Osimertinib

146 locations incl. Birmingham

Sponsor: PrECOG, LLC.

Sex: All·Age: 18+

Code: NCT06538038·Recruiting

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A Study of Obexelimab in Patients With Systemic Lupus Erythematosus

for Systemic Lupus Erythematosus

16 locations incl. Fresno

Sponsor: Zenas BioPharma (USA), LLC

Sex: All·Age: 18 - 70

Code: NCT06559163·Phase 2·Recruiting

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LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis

for Metabolic Dysfunction Associated Steatohepatitis (MASH)

Drug: Survodutide

165 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06632444·Phase 3·Recruiting

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A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma

for Monoclonal Gammopathy of Undetermined Significance (MGUS)

Drug: Linvoseltamab

7 locations incl. Baltimore

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06140524·Phase 2·Recruiting

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Single Versus Dual Implant Fixation of Distal Femur Fractures

for Articular Fractures

16 locations incl. Birmingham

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06286670·Recruiting

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A Study of VET3-TGI in Patients With Solid Tumors

for Solid Tumor, Adult

7 locations incl. Los Angeles

Sponsor: KaliVir Immunotherapeutics

Sex: All·Age: 18+

Code: NCT06444815·Phase 1·Recruiting

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A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)

for Cystic Fibrosis

4 locations incl. Kansas City

Sponsor: Spirovant Sciences, Inc.

Sex: All·Age: 18 - 65

Code: NCT06526923·Phase 1, Phase 2·Recruiting

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Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC

for High-Risk Non-Muscle-Invasive Bladder Cancer

65 locations incl. Phoenix

Sponsor: CG Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06567743·Phase 2·Recruiting

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Surgiphor Us in TSA

for Total Shoulder Arthroplasty

1 location in Philadelphia

Sponsor: Rothman Institute Orthopaedics

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06601803·Phase 4·Enrolling By Invitation

Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

Drug: Venetoclax

167 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 59

Code: NCT05554393·Phase 2·Recruiting

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Expanding Liver Transplant Immunosuppression Minimization Via Everolimus

for Liver Transplant

8 locations incl. Phoenix

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+

Code: NCT06280950·Phase 2·Recruiting

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Peer Facilitated Waitlist Controlled Transportation Study

for Serious Mental Illness

1 location in Philadelphia

Sponsor: Temple University

Sex: All·Age: 18 - 65

Code: NCT06370767·Recruiting

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MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

for Pancreatic Ductal Adenocarcinoma

25 locations incl. Duarte

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06586515·Phase 1·Recruiting

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A Study to Investigate the Safety and Effectiveness of a Coagulation Factor IX Gene Insertion Therapy (REGV131-LNP1265) in Pediatric, Adolescent and Adult Participants With Hemophilia B

for Hemophilia B

14 locations incl. Los Angeles

Sponsor: Regeneron Pharmaceuticals

Sex: Male·Age: 2+

Code: NCT06379789·Phase 1, Phase 2·Recruiting

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Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

for Metastatic Dedifferentiated Liposarcoma

245 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06422806·Phase 3·Recruiting

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Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

for Treatment Resistant Depression

24 locations incl. Birmingham

Sponsor: Abbott Medical Devices

Sex: All·Age: 22 - 70

Code: NCT06423430·Recruiting

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Postpartum Care in the NICU (PeliCaN) Transitions

for Stress Disorders, Post-Traumatic

1 location in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 16+

Code: NCT06521398·Recruiting

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A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis

for Non-cystic Fibrosis Bronchiectasis

29 locations incl. Birmingham

Sponsor: Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA

Sex: All·Age: 18 - 80

Code: NCT06559150·Phase 2·Recruiting

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A Study of the Efficacy and Safety of Belimumab in Adults With Interstitial Lung Disease Associated With Connective Tissue Disease

for Lung Diseases, Interstitial

16 locations incl. Los Angeles

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06572384·Phase 3·Recruiting

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Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine

for Migraine

Drug: Ubrogepant

103 locations incl. Birmingham

Sponsor: AbbVie

Sex: Female·Age: 18+

Code: NCT06417775·Phase 3·Recruiting

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The Effects of Healthy Diets With Plant Oils on Heart and Metabolic Health

for Cardiovascular Diseases

1 location in University Park

Sponsor: Penn State University

Sex: All·Age: 25 - 60·Accepts healthy volunteers

Code: NCT06216678·Recruiting

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A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

for Melanoma

104 locations incl. Chandler

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06246916·Phase 3·Recruiting

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Safety and Effectiveness of Mechanical Thrombectomy Using the Anaconda ANA Funnel Catheter

for Acute Ischemic Stroke From Large Vessel Occlusion

11 locations incl. Jacksonville

Sponsor: Anaconda Biomed S.L.

Sex: All·Age: 22 - 85

Code: NCT06370182·Recruiting

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RevCore for In Stent Thrombosis

for In-stent Thrombosis

16 locations incl. New Haven

Sponsor: Inari Medical

Sex: All·Age: 18+

Code: NCT06394739·Recruiting

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Refer2Quit: Evaluating a Proactive, Tailored, Population Health Approach for Tobacco Treatment for Household Smokers Through a Pediatric Care Network

for Smoking

1 location in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 18+

Code: NCT06582693·Recruiting

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A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

for NASH - Nonalcoholic Steatohepatitis

Drug: Efruxifermin

168 locations incl. Birmingham

Sponsor: Akero Therapeutics, Inc

Sex: All·Age: 18 - 80

Code: NCT06528314·Phase 3·Recruiting

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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

for Crohn's Disease

64 locations incl. Dothan

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT06548542·Phase 2·Recruiting

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A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

for Pulmonary Hypertension

31 locations incl. Phoenix

Sponsor: Tectonic Therapeutic

Sex: All·Age: 18 - 83

Code: NCT06616974·Phase 2·Recruiting

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Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

for Lung Transplant

18 locations incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06399302·Recruiting

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PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm

for Coronary Artery Disease

18 locations incl. Chandler

Sponsor: Kardion Inc

Sex: All·Age: 18 - 90

Code: NCT06445608·Recruiting

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First-in-human Study of DB-1419 for Advanced/Metastatic Solid Tumors

for Solid Tumor, Adult

9 locations incl. Los Angeles

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT06554795·Phase 1, Phase 2·Recruiting

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Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

for Huntington Disease

13 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 25 - 60

Code: NCT06667414·Recruiting

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Strict Versus Permissive Thresholds for Initiation of Pharmacotherapy in Gestational Diabetes

for Gestational Diabetes

2 locations incl. Rochester

Sponsor: Thomas Jefferson University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06419777·Recruiting

Apply to this trial