Paid Clinical Trials in North Carolina

North Carolina has 2,943 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

Filter results

Filter results

State

City

Phase

Study type

Intervention

Recruitment status

Condition

Sex

Age

Healthy volunteers only

2,944 clinical trials

↓ Download CSV

Improving Appetite Self-Regulation in African American Adults With Type 2 Diabetes

for Type 2 Diabetes

2 locations incl. Kannapolis

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT05741125·Recruiting

Apply to this trial

A Study to Learn How Avacincaptad Pegol (Izervay™) is Used in Clinical Practice in People Who Have Geographic Atrophy

for Geographic Atrophy

65 locations incl. Phoenix

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: All ages

Code: NCT06779773·Recruiting

Apply to this trial

Evaluation of the Pathobiology of CALR-mutated MPN Cells

for Myeloproliferative Neoplasm

2 locations incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06480591·Recruiting

Apply to this trial

A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

for Chronic Graft-versus-host-disease

33 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 12+

Code: NCT06585774·Phase 3·Recruiting

Apply to this trial

Postoperative Radiotherapy for Intermediate- and High-risk Patients With HNSCC Greater Than 6 Weeks After Surgery

for Head and Neck Cancer

3 locations incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06607406·Recruiting

Apply to this trial

Rehabilitation Outcomes Study

for Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06674889·Recruiting

Apply to this trial

A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

for Non-Small Cell Lung Cancer

Drug: Telisotuzumab Vedotin

38 locations incl. Chandler

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06568939·Phase 2·Recruiting

Apply to this trial

A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

for Parkinson Disease

45 locations incl. Sun City

Sponsor: Neuron23 Inc.

Sex: All·Age: 40 - 80

Code: NCT06680830·Phase 2·Recruiting

Apply to this trial

Study to Evaluate Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-291 Moves Through the Body in Adult Participants With Non-Hodgkin's Lymphoma

for Non-Hodgkin's Lymphoma

5 locations incl. Huntersville

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06667687·Phase 1·Recruiting

Apply to this trial

Treating Binge Eating and Obesity Digitally in Black Women

for Binge Eating

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05693896·Recruiting

Apply to this trial

An Investigational Study Examining the Efficacy of QbMobile in Treatment Monitoring in Individuals With ADHD

for Attention Deficit Disorder With Hyperactivity (ADHD)

7 locations incl. Mobile

Sponsor: Qbtech AB

Sex: All·Age: 6 - 60

Code: NCT07217977·Enrolling By Invitation

A Study of Tagraxofusp in Combination With Venetoclax and Azacitidine in Adults With Untreated CD123+ Acute Myeloid Leukemia Who Cannot Undergo Intensive Chemotherapy

for Acute Myeloid Leukemia

Drug: Venetoclax

24 locations incl. Los Angeles

Sponsor: Stemline Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06456463·Phase 2·Recruiting

Apply to this trial

SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma

for Melanoma, Cutaneous Malignant

40 locations incl. Phoenix

Sponsor: Immatics US, Inc.

Sex: All·Age: 18+

Code: NCT06743126·Phase 3·Recruiting

Apply to this trial

Collecting Outcomes and Managing Pain After Surgery

for Surgery

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 90

Code: NCT03834818·Recruiting

Apply to this trial

Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)

for Adult Growth Hormone Deficiency

17 locations incl. Birmingham

Sponsor: VA Office of Research and Development

Sex: All·Age: 21 - 55

Code: NCT04867317·Phase 3·Recruiting

Apply to this trial

Safety and Preliminary Effectiveness of BNT317, an Investigational Therapy for Advanced Solid Tumors

for Advanced Solid Tumor

7 locations incl. Louisville

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT06750185·Phase 1·Recruiting

Apply to this trial

A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia

for Sickle Cell Disease

Drug: Etavopivat

39 locations incl. Birmingham

Sponsor: Novo Nordisk A/S

Sex: All·Age: 2+

Code: NCT06609226·Phase 3·Recruiting

Apply to this trial

A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)

for Type 2 Diabetes

Drug: Dulaglutide

41 locations incl. Tucson

Sponsor: Eli Lilly and Company

Sex: All·Age: 10 - 17

Code: NCT06739122·Phase 3·Recruiting

Apply to this trial

Physical Activity and Community EmPOWERment Project

for Intellectual Disability

2 locations incl. Fayetteville

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06740162·Recruiting

Apply to this trial

A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age

for Chickenpox

60 locations incl. Mobile

Sponsor: GlaxoSmithKline

Sex: All·Age: 12 Months - 15 Months·Accepts healthy volunteers

Code: NCT06740630·Phase 3·Recruiting

Apply to this trial

A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis

for Arthritis, Psoriatic

23 locations incl. Glendale

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06807424·Phase 3·Recruiting

Apply to this trial

A Clinical Trial to Assess the Efficacy, Safety, and Tolerability of a Repeat Dose of Fasedienol Nasal Spray for the Acute Treatment of Anxiety in Adults With Social Anxiety Disorder

for Social Anxiety Disorder

9 locations incl. Sherman Oaks

Sponsor: VistaGen Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06809179·Phase 2·Recruiting

Apply to this trial

Confirmatory Study of Topical HyBryte™ vs. Placebo for the Treatment of CTCL

for CTCL/ Mycosis Fungoides

17 locations incl. Phoenix

Sponsor: Soligenix

Sex: All·Age: 18+

Code: NCT06470451·Phase 3·Recruiting

Apply to this trial

Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

for Non-small Cell Lung Cancer

36 locations incl. Anchorage

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT06712316·Phase 2, Phase 3·Recruiting

Apply to this trial

Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)

for Delirium

14 locations incl. Los Angeles

Sponsor: Massachusetts General Hospital

Sex: All·Age: 60+

Code: NCT06192615·Phase 3·Recruiting

Apply to this trial

Olfactory Biopsies

for Alzheimer Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07021040·Recruiting

Apply to this trial

Utility of Random Biopsies in Patients With Inflammatory Bowel Disease

for Inflammatory Bowel Diseases

20 locations incl. Birmingham

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06560021·Enrolling By Invitation

A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

for Chronic Lymphocytic Leukemia

21 locations incl. Chandler

Sponsor: Loxo Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06588478·Phase 2·Recruiting

Apply to this trial

Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

for Cutaneous Squamous Cell Carcinoma (CSCC)

Drug: Cemiplimab

45 locations incl. Phoenix

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06585410·Phase 3·Recruiting

Apply to this trial

Genetic and Environmental Risk Factors for Hemorrhagic Stroke

for Stroke

7 locations incl. Chicago

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00682695·Recruiting

Apply to this trial

Cognition, Flavonoids, Exercise, Gut Microbiome

for Cognitive Decline, Mild

1 location in Kannapolis

Sponsor: Appalachian State University

Sex: All·Age: 65 - 85·Accepts healthy volunteers

Code: NCT06495190·Recruiting

Apply to this trial

MAINTAIN (Mucosal AblatIoN Therapy After INcretins)

for Obesity and Obesity-related Medical Conditions

2 locations incl. Cary

Sponsor: Dr. Christopher McGowan

Sex: All·Age: 21 - 65

Code: NCT06734312·Recruiting

Apply to this trial

Thriving Hearts: Healing-Centered, Integrated, Community Maternity Care

for Hypertensive Disorder of Pregnancy

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 15+

Code: NCT06744231·Enrolling By Invitation

Promoting Resilience in Women With Breast Cancer (PRISM -MBC)

for Breast Cancer

2 locations incl. Birmingham

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06855654·Recruiting

Apply to this trial

Effectiveness and Safety of the RIGHTEST Continuous Glucose Monitoring System for Blood Glucose Management in Persons With Diabetes Mellitus

for Diabetes Mellitus

13 locations incl. Guntersville

Sponsor: Bionime Corporation

Sex: All·Age: 18+

Code: NCT04838392·Not Yet Recruiting

OUD (Opioid Use Disorder) Target Trial

for Opioid Use Disorder

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06585709·Recruiting

Apply to this trial

REvision of VSG with Ablation of the Mucosa Procedure

for Obesity and Obesity-related Medical Conditions

1 location in Cary

Sponsor: Dr. Christopher McGowan

Sex: All·Age: 22 - 60

Code: NCT06671119·Recruiting

Apply to this trial

A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Disease on Hemodialysis With a Central Venous Catheter (Phase IIa)

for Staphylococcus Aureus

43 locations incl. Huntsville

Sponsor: AstraZeneca

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT06749457·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia

for Narcolepsy Type 1

Drug: ORX750

29 locations incl. Auburn

Sponsor: Centessa Pharmaceuticals (UK) Limited

Sex: All·Age: 18 - 65

Code: NCT06752668·Phase 2·Recruiting

Apply to this trial

Rare Glycogen Storage Diseases Natural History Study

for Glycogen Storage Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 0 - 90

Code: NCT06795152·Recruiting

Apply to this trial