Paid Clinical Trials in North Carolina

North Carolina has 2,943 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder

for Major Depressive Disorder

46 locations incl. Phoenix

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18 - 74

Code: NCT06775379·Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease

for Focal Segmental Glomerulosclerosis

Drug: Brivekimig

16 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 16 - 75

Code: NCT06500702·Phase 2·Recruiting

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Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

for Heart Failure

88 locations incl. Alexander City

Sponsor: Cytokinetics

Sex: All·Age: 18 - 85

Code: NCT06736574·Phase 3·Recruiting

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Dissolved Phase HXe-129 MRI: A Novel Biomarker to Quantify Pulmonary Pathology

for Electronic Cigarette Related Lung Damage

2 locations incl. Durham

Sponsor: Y. Michael Shim, MD

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT06856525·Phase 2, Phase 3·Recruiting

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Accelerating TMS for Cervical Dystonia

for Isolated Cervical Dystonia

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06328114·Phase 2·Enrolling By Invitation

Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors

for Hematopoietic Stem Cell Transplant

3 locations incl. Tampa

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06328127·Recruiting

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"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"

for Major Depressive Disorder

46 locations incl. Phoenix

Sponsor: Cybin IRL Limited

Sex: All·Age: 18 - 85

Code: NCT06564818·Phase 3·Recruiting

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A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

for Metastatic Uveal Melanoma

Drug: Nivolumab

29 locations incl. Scottsdale

Sponsor: Replimune, Inc.

Sex: All·Age: All ages

Code: NCT06581406·Phase 2, Phase 3·Recruiting

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Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial

for Mild Cognitive Impairment (MCI)

4 locations incl. Miami

Sponsor: Columbia University

Sex: All·Age: 55 - 89

Code: NCT06601933·Phase 2·Recruiting

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Efficacy and Safety of Extended TARPEYO® Treatment Beyond 9 Months in Adult Patients With Primary IgA Nephropathy

for IgA Nephropathy

37 locations incl. Birmingham

Sponsor: Calliditas Therapeutics AB

Sex: All·Age: 18+

Code: NCT06712407·Phase 4·Recruiting

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A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

for Graves' Disease

Drug: IMVT-1402

64 locations incl. Phoenix

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18 - 75

Code: NCT06727604·Phase 2·Recruiting

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Efficacy & Safety of LOBO™ Vascular Occlusion Device for Embolization of Pulmonary Arteriovenous Malformations

for Pulmonary Arteriovenous Malformations

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 14+

Code: NCT06735976·Recruiting

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RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE

for Osteoporosis

23 locations incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 50+

Code: NCT06455085·Recruiting

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Ivosidenib Plus Durvalumab and Gemcitabine/Cisplatin as First-Line Therapy in Participants With Locally Advanced or Metastatic Cholangiocarcinoma With an IDH1 Mutation

for Locally Advanced, Unresectable or Metastatic Cholangiocarcinoma With an IDH1 Mutation

Drug: Durvalumab

8 locations incl. Los Alamitos

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT06501625·Phase 1, Phase 2·Recruiting

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A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

for Carcinoma, Non-Small-Cell Lung

Drug: Amivantamab

150 locations incl. Daphne

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06667076·Phase 2·Recruiting

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A Study of Belantamab Mafodotin Administered in Combination With Lenalidomide and Dexamethasone (BRd) Versus Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Who Are Ineligible for Autologous Stem Cell Transplantation (TI-NDMM)

for Multiple Myeloma

Drug: Belantamab mafodotin

30 locations incl. Mobile

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06679101·Phase 3·Recruiting

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Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure

for Heart Failure

57 locations incl. Phoenix

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT06526195·Recruiting

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Remote Hypertension Management for Black Patients

for Uncontrolled Hypertension

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 21 - 85

Code: NCT06527794·Recruiting

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A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

for Locally Advanced Unresectable or Metastatic Gastric Adenocarcinoma

8 locations incl. Duarte

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06628310·Phase 2·Recruiting

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The Impact of an Evidence-Based Parenting Service on Maternal Sensitivity and Infant Cellular Aging in a Population of Under-Resourced Families

for Parent Child Relationship

1 location in Raleigh

Sponsor: University of Washington

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06740266·Recruiting

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Study of GalaFLEX LITE™ Scaffold in Treatment of Capsular Contracture After Breast Implant Augmentation

for Capsular Contracture Associated With Breast Implant

34 locations incl. Scottsdale

Sponsor: C. R. Bard

Sex: Female·Age: 22 - 70

Code: NCT05945329·Recruiting

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A Randomized, Double-Blind, Placebo-Controlled Trial on Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Combination in Participants 12 Years and Older With Asthma

for Asthma

87 locations incl. Phoenix

Sponsor: Teva Branded Pharmaceutical Products R&D LLC

Sex: All·Age: 12+

Code: NCT06664619·Phase 3·Recruiting

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A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.

for Candidemia

23 locations incl. Birmingham

Sponsor: Basilea Pharmaceutica

Sex: All·Age: 18+

Code: NCT05421858·Phase 3·Recruiting

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A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Participants With Moderately to Severely Active Ulcerative Colitis

for Moderately to Severely Active Ulcerative Colitis

Drug: Afimkibart

71 locations incl. Dothan

Sponsor: Hoffmann-La Roche

Sex: All·Age: 16 - 80

Code: NCT06588855·Phase 3·Recruiting

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Study to Evaluate Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene

for Retinitis Pigmentosa (RP)

11 locations incl. San Francisco

Sponsor: Laboratoires Thea

Sex: All·Age: 8+

Code: NCT06627179·Phase 2·Recruiting

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A Study to Test Whether BI 3032950 Helps People With Ulcerative Colitis

for Ulcerative Colitis

14 locations incl. Scottsdale

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18 - 80

Code: NCT06636656·Phase 2·Recruiting

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Key Longitudinal Associations With Risk and Glioblastoma Outcomes

for Glioblastoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06625684·Recruiting

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A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Crohn's Disease.

for Crohn's Disease

19 locations incl. Sun City

Sponsor: Sanofi

Sex: All·Age: 18 - 75

Code: NCT06637631·Phase 2·Recruiting

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A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease

for COVID-19 SARS-CoV-2 Infection

85 locations incl. Little Rock

Sponsor: Pfizer

Sex: All·Age: 12+

Code: NCT06679140·Phase 3·Recruiting

Apply to this trial

Epcoritamab in Previously Treated WM

for Waldenstrom Macroglobulinemia

Drug: Epcoritamab

3 locations incl. Boston

Sponsor: Gottfried von Keudell, MD PhD

Sex: All·Age: 18+

Code: NCT06510491·Phase 2·Recruiting

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Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma

for Neuroblastoma

12 locations incl. Little Rock

Sponsor: Giselle Sholler

Sex: All·Age: 1 - 21

Code: NCT06540963·Phase 2·Recruiting

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A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

for Carcinoma, Non-Small-Cell Lung

16 locations incl. Farmington

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 18+

Code: NCT06667908·Phase 2·Recruiting

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Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder (ASD) in Pediatric Patients

for Irritability Associated With Autism Spectrum Disorder

39 locations incl. Little Rock

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 5 - 17

Code: NCT06706674·Phase 3·Recruiting

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CARES (Comprehensive Analgesic, Recovery, and Education Support) for Surgery Trial

for Chronic Pain

4 locations incl. Stanford

Sponsor: Stanford University

Sex: All·Age: 18 - 75

Code: NCT06027099·Phase 3·Recruiting

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First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.

for Solid Tumor

20 locations incl. Birmingham

Sponsor: Corbus Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06603844·Phase 1, Phase 2·Recruiting

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Evaluation of a Health System Integrated Model for Postpartum Education and Support in Rural Populations

for Health Care Utilization

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06682520·Recruiting

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Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

for Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS)

9 locations incl. Denver

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT06465953·Phase 3·Recruiting

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A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

for Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

24 locations incl. Phoenix

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06679946·Phase 3·Enrolling By Invitation

A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)

for Coronavirus Disease (COVID-19)

71 locations incl. Cullman

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06667700·Phase 3·Recruiting

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A Study to Evaluate the Effectiveness of Long-acting (LA) Cabotegravir (CAB) + Rilpivirine (RPV) LA When Given to Participants With Detectable HIV-1

for HIV Infections

41 locations incl. Birmingham

Sponsor: ViiV Healthcare

Sex: All·Age: 12+

Code: NCT06694805·Phase 3·Recruiting

Apply to this trial