A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Part of paid clinical trials in Phoenix, Arizona.

Sponsor
Alnylam Pharmaceuticals
Study ID
NCT06679946
Phase
PHASE3
Status
Enrolling By Invitation

Conditions

  • Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Vutrisiran — DRUG
    Vutrisiran administered SC q3M

Study Details

The purpose of this study is to obtain safety, efficacy, and pharmacodynamic data on the use of vutrisiran in patients with ATTR amyloidosis with cardiomyopathy who continued on extended use of vutrisiran, or switched from patisiran.

Key Dates

Start date
Dec 3, 2024
Status verified
Feb 2026
Primary completion
Mar 31, 2028
Completion
Mar 31, 2028

Study Design

Enrollment
700 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Vutrisiran 25 mg
    Participants will receive vutrisiran 25 mg administered subcutaneously (SC) once every 3 months (q3M).

Primary Outcome Measure

Frequency of Adverse Events (AEs) [ Time Frame: Up to 36 Months ]

Locations (24)

FacilityCityStateZIPSite coordinators
Clinical Trial SitePhoenixArizona85054-
Clinical Trial SiteBeverly HillsCalifornia90211-
Clinical Trial SiteLa JollaCalifornia92037-
Clinical Trial SiteStanfordCalifornia94305-
Clinical Trial SiteWashington D.C.District of Columbia20010-
Clinical Trial SiteChicagoIllinois60637-
Clinical Trial SiteGlenviewIllinois60026-
Clinical Trial SiteIndianapolisIndiana46202-
Clinical Trial SiteKansas CityKansas66160-
Clinical Trial SiteBaltimoreMaryland21287-
Clinical Trial SiteBostonMassachusetts02115-
Clinical Trial SiteBostonMassachusetts02118-
Clinical Trial SiteRochesterMinnesota55905-
Clinical Trial SiteSt LouisMissouri63110-
Clinical Trial SiteOmahaNebraska68198-
Clinical Trial SiteNew YorkNew York10029-
Clinical Trial SiteNew YorkNew York10032-
Clinical Trial SiteDurhamNorth Carolina27710-
Clinical Trial SiteClevelandOhio44195-
Clinical Trial SiteColumbusOhio43214-
Clinical Trial SitePhiladelphiaPennsylvania19104-
Clinical Trial SiteNashvilleTennessee37232-
Clinical Trial SiteDallasTexas75246-
Clinical Trial SiteSalt Lake CityUtah84132-

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