Cognition, Flavonoids, Exercise, Gut Microbiome

Conditions

• Cognitive Decline, Mild

Eligibility Criteria

Sex

ALL

Age

65 Years - 85 Years

Healthy Volunteers

Accepted

Interventions

• Blueberry — DIETARY_SUPPLEMENT
  50 g/d blueberry powder supplement
• Walking — BEHAVIORAL
  Five 45-min walking sessions per week
• Placebo — DIETARY_SUPPLEMENT
  50 g/d placebo powder supplement
• Stretching — BEHAVIORAL
  Five 45-min stretching sessions per week

Study Details

This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants identified as experiencing age-related cognitive changes. This project's hypothesis is that the combination of flavonoid-rich diet and routine physical activity may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the gut microbiome.

Key Dates

Start date

Jan 1, 2025

Status verified

Mar 2025

Primary completion

Dec 31, 2027

Completion

Dec 31, 2028

Study Design

Enrollment

240 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Blueberry + walking
  Blueberry intake combined with walking exercise.
• Experimental: Blueberry + stretching
  Blueberry intake combined with stretching exercise.
• Active Comparator: Placebo + walking
  Placebo intake combined with walking exercise.
• Active Comparator: Placebo + stretching
  Placebo intake combined with stretching exercise.

Primary Outcome Measure

Cognition [ Time Frame: Change from pre-study to 6-weeks and 12-weeks ]

Central Contacts

• David C Nieman, DrPH
  8287730056
  [email protected]
• Camila A Olson, PhD
  7042505352
  [email protected]

Locations (1)

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