Paid Clinical Trials in North Carolina

North Carolina has 2,943 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 18, 2026.

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2,944 clinical trials

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Efficacy and Safety Study of Halneuron in the Treatment of Chemotherapy-Induced Neuropathic Pain

for Chemotherapy Induced Neuropathic Pain

25 locations incl. Sheffield

Sponsor: Dogwood Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06848348·Phase 2·Recruiting

Apply to this trial

Psyllium in Pediatric IBS

for Irritable Bowel Syndrome

1 location in Durham

Sponsor: Dr Bruno Chumpitazi, M.D.

Sex: All·Age: 12 - 17

Code: NCT06639984·Phase 2·Recruiting

Apply to this trial

Clinical Trial on the Effect of the Flexible Suturing System With Anchors (FSSA) in Full-thickness Rotator Cuff Tendon Tears

for Rotator Cuff Tears

3 locations incl. Charlotte

Sponsor: Integrity Orthopaedics, Inc.

Sex: All·Age: 18 - 70

Code: NCT06868108·Enrolling By Invitation

Open-Label Safety Study of Solriamfetol in Subjects With Binge Eating Disorder

for Binge-Eating Disorder

Drug: Solriamfetol

31 locations incl. Encino

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18 - 56

Code: NCT06878976·Phase 3·Enrolling By Invitation

Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST)

for Breast Cancer

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: Female·Age: 50+

Code: NCT06902311·Phase 2·Recruiting

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Safety and Efficacy of Aloe Vera in the Management of the Symptoms of Interstitial Cystitis

for Interstitial Cystitis

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18 - 80

Code: NCT04734106·EARLY_Phase 1·Recruiting

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A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease

for Sickle Cell Disease

Drug: Etavopivat

50 locations incl. Birmingham

Sponsor: Novo Nordisk A/S

Sex: All·Age: 12+

Code: NCT06612268·Phase 3·Recruiting

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A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

7 locations incl. Irvine

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06697197·Phase 1, Phase 2·Recruiting

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Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease

for Degenerative Disc Disease

19 locations incl. Napa

Sponsor: VIVEX Biologics, Inc.

Sex: All·Age: 22 - 85

Code: NCT06778447·Recruiting

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MB-105 in Patients With CD5 Positive T-cell Lymphoma

for Lymphoma, T-Cell

12 locations incl. San Diego

Sponsor: March Biosciences Inc

Sex: All·Age: 18+

Code: NCT06534060·Phase 2·Recruiting

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A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years

for Chronic Migraine

Drug: Atogepant

31 locations incl. Huntsville

Sponsor: AbbVie

Sex: All·Age: 12 - 17

Code: NCT06810505·Phase 3·Recruiting

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IDEAL: Efficacy of Porcine Placental Extracellular Matrix Augmented Plus Standard of Care (SOC) Versus SOC Alone for the Management of Diabetic Foot Ulcers

for Wound Heal

9 locations incl. Los Angeles

Sponsor: ConvaTec Inc.

Sex: All·Age: 18+

Code: NCT06616844·Recruiting

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Optimization of Beta-lactam Dosing in Critically Ill Patients With Cystatin C (OPTIMIZE-GNI)

for Bacterial Infection

10 locations incl. Torrance

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+

Code: NCT06709521·Phase 4·Recruiting

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A Study of CREXONT (Carbidopa and Levodopa) Extended-Release Capsules in Participants With Parkinson's Disease

for Parkinson Disease

27 locations incl. Phoenix

Sponsor: Impax Laboratories, LLC

Sex: All·Age: 18+

Code: NCT06765668·Phase 4·Recruiting

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A Study of Nipocalimab or Intravenous Immunoglobulin (IVIG) in Pregnancies At Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)

for Thrombocytopenia, Neonatal Alloimmune

Drug: Nipocalimab

12 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: Female·Age: 18 - 45

Code: NCT06533098·Phase 3·Recruiting

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A Clinical Study to Evaluate the Safety and Efficacy of the FloStent in Men With Benign Prostatic Hyperplasia Symptoms

for Benign Prostatic Hyperplasia

19 locations incl. Bakersfield

Sponsor: Rivermark Medical

Sex: Male·Age: 45+

Code: NCT06849258·Recruiting

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A Phase 1b/2a Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With mCRPC

for mCRPC (Metastatic Castration-resistant Prostate Cancer)

18 locations incl. Fountain Valley

Sponsor: Pathos AI, Inc.

Sex: Male·Age: 18+

Code: NCT06785636·Phase 1, Phase 2·Recruiting

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A Study of TAK-360 in Adults With Idiopathic Hypersomnia

for Idiopathic Hypersomnia

13 locations incl. Redwood City

Sponsor: Takeda

Sex: All·Age: 18 - 70

Code: NCT06812078·Phase 2·Recruiting

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Basal-like PDAC Treated With Gemcitabine, Erlotinib, and Nab-paclitaxel

for Pancreatic Adenocarcinoma

Drug: Erlotinib

1 location in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06483555·Phase 1, Phase 2·Recruiting

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Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

for Castration-Resistant Prostate Carcinoma

107 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06632977·Phase 2·Recruiting

Apply to this trial

REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE

for Aortic Stenosis

71 locations incl. Birmingham

Sponsor: Medtronic Cardiovascular

Sex: All·Age: 18 - 105

Code: NCT06777368·Recruiting

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A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease

for Proteinuric Kidney Disease

Drug: MZE829

72 locations incl. Decatur

Sponsor: Maze Therapeutics

Sex: All·Age: 18 - 68

Code: NCT06830629·Phase 2·Recruiting

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Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure

for Chronic Lymphocytic Leukaemia

3 locations incl. Charlotte

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06651970·Phase 4·Recruiting

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Effect of Acetylcholinesterase Inhibitors on Bone Metabolism

for Osteoporosis

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 50+

Code: NCT06041789·Phase 2·Recruiting

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EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

for Glioblastoma

32 locations incl. Phoenix

Sponsor: NovoCure GmbH

Sex: All·Age: 18+

Code: NCT06556563·Phase 3·Recruiting

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FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)

for Obesity and Overweight

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 75

Code: NCT06724406·Recruiting

Apply to this trial

Non-Invasive Preeclampsia Screening and Biobank

for Preeclampsia (PE)

21 locations incl. Glendale

Sponsor: Sequenom, Inc.

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06643741·Recruiting

Apply to this trial

Study of Olutasidenib and Temozolomide in HGG

for High Grade Glioma

11 locations incl. Aurora

Sponsor: Rigel Pharmaceuticals

Sex: All·Age: 12 - 39

Code: NCT06161974·Phase 2·Recruiting

Apply to this trial

StrokeNet Thrombectomy Endovascular Platform

for Ischemic Stroke

41 locations incl. Birmingham

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT06289985·Recruiting

Apply to this trial

BOOM-IBD2 Pivotal Clinical Trial

for Ulcerative Colitis

19 locations incl. Folsom

Sponsor: Boomerang Medical

Sex: All·Age: 18 - 85

Code: NCT06571669·Recruiting

Apply to this trial

Telehealth Intervention for Improving Distress and Financial Toxicity in the Caregivers

for Hematopoietic and Lymphatic System Neoplasm

1 location in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06709404·Recruiting

Apply to this trial

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

for Breast Carcinoma

464 locations incl. Fairbanks

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06418204·Recruiting

Apply to this trial

A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

for Chronic Lymphocytic Leukaemia

13 locations incl. Boston

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06564038·Phase 1, Phase 2·Recruiting

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Testing Whether High Dose Chemotherapy and Infusion of the Patients' Own Stem Cells Improves Survival in Patients With Peripheral T-cell Lymphoma Who Achieved a Complete Response at the End of the Initial Chemotherapy

for Anaplastic Large Cell Lymphoma, ALK-Negative

158 locations incl. Birmingham

Sponsor: Eastern Cooperative Oncology Group

Sex: All·Age: 18 - 75

Code: NCT06724237·Phase 3·Recruiting

Apply to this trial

Tissue Repair Gel in Venous Leg Ulcers (US)

for Venous Leg Ulcer

33 locations incl. Tucson

Sponsor: TR Therapeutics

Sex: All·Age: 18+

Code: NCT06707090·Phase 3·Recruiting

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FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

for Metastatic Head and Neck Squamous Cell Carcinoma

53 locations incl. Birmingham

Sponsor: Bicara Therapeutics

Sex: All·Age: 18+

Code: NCT06788990·Phase 2, Phase 3·Recruiting

Apply to this trial

Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPH

for CTEPH

1 location in Durham

Sponsor: Dr Sudarshan Rajagopal

Sex: All·Age: 18+

Code: NCT05140525·Phase 3·Recruiting

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A Long-Term Study of ALKS 2680 in Subjects With Narcolepsy and Idiopathic Hypersomnia

for Narcolepsy Type 1

Drug: ALKS 2680

30 locations incl. Phoenix

Sponsor: Alkermes, Inc.

Sex: All·Age: 18 - 70

Code: NCT06767683·Phase 2, Phase 3·Recruiting

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DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

for Pulmonary Hypertension Due to Lung Diseases and Hypoxia

66 locations incl. Birmingham

Sponsor: United Therapeutics

Sex: All·Age: 18+

Code: NCT06388421·Recruiting

Apply to this trial

US National TOP Registry

for Lung Transplant

7 locations incl. Phoenix

Sponsor: TransMedics

Sex: All·Age: All ages

Code: NCT06513091·Recruiting

Apply to this trial