RecruitingPhase 3Drug trialMinimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)This is a pragmatic phase III, randomized, blinded, double placebo-controlled, three-arm trial of elderly patients following cardiac surgery to assess the relationship between nighttime intravenous (IV) and sublingual dexmedetomidine on postoperative delirium and functional outcomes after surgery.