Clinical Trials at University of Minnesota

As of June 2026, 327 paid clinical trials are recruiting at University of Minnesota, located at University of Minnesota Clinical Research Unit (CRU), 516 Delaware St SE, Minneapolis, MN 55455 in Minneapolis, Minnesota. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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327 clinical trials at University of Minnesota

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Letrozole in Uterine Leiomyosarcoma

for Uterine Leiomyosarcoma

25 locations incl. Aurora

Sponsor: GOG Foundation

Sex: Female·Age: 18+

Code: NCT05649956·Phase 2·Recruiting

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VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]

for Advanced Melanoma

Drug: Nivolumab

50 locations incl. Gilbert

Sponsor: Replimune, Inc.

Sex: All·Age: 12+

Code: NCT06264180·Phase 3·Recruiting

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Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder

for Methamphetamine-dependence

11 locations incl. Little Rock

Sponsor: National Institute on Drug Abuse (NIDA)

Sex: All·Age: 18 - 65

Code: NCT06233799·Phase 3·Recruiting

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Topical and Local TXA in Facelifts - A Randomized Controlled Double Blinded Study

for Hemophilia

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT06345833·EARLY_Phase 1·Recruiting

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Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

for Amblyopia

73 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4 - 7

Code: NCT06380517·Phase 3·Recruiting

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Assessment of Usability and Satisfaction With a Take-home Device Presenting Sound and Body Stimulation for Back Pain

for Chronic Lower Back Pain

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT06619418·Recruiting

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A Long-Term Follow-Up Study of Participants With Sickle Cell Disease or Transfusion Dependent β-Thalassemia Who Received EDIT-301

for Sickle Cell Disease

16 locations incl. Oakland

Sponsor: Editas Medicine, Inc.

Sex: All·Age: 12 - 50

Code: NCT06363760·Enrolling By Invitation

Somatic Mosaicism in Twins Discordant for Childhood Cancer

for Pediatric Central Nervous System Tumor

1 location in Minneapolis

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 18

Code: NCT06054295·Recruiting

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Pathways Mediating Impaired Postural Control in Parkinson's Disease

for Parkinson Disease

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 45 - 80·Accepts healthy volunteers

Code: NCT06464029·Recruiting

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Cognition and Ultrasound

for Healthy Participants

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07220655·Recruiting

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Health Outcomes of Parents With Cystic Fibrosis-Aim 2

for Cystic Fibrosis

18 locations incl. Birmingham

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT06296394·Recruiting

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Inhibitory Mechanisms of Negative Urgency in Adolescent Suicidal Behavior

for Suicidal Behavior

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 13 - 21

Code: NCT05652153·Recruiting

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Prophylactic Antibiotics in Cystectomy With Diversion

for Muscle-Invasive Bladder Carcinoma

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT06190197·EARLY_Phase 1·Recruiting

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A Follow-up Study to Test Long-term Treatment With Nerandomilast in People With Pulmonary Fibrosis Who Took Part in a Previous Study With Nerandomilast

for Idiopathic Pulmonary Fibrosis

Drug: Nerandomilast

58 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06238622·Phase 3·Recruiting

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Multimodal Profiling of Response to Pediatric Comprehensive Behavioral Intervention for Tics

for Tourette Syndrome

2 locations incl. San Diego

Sponsor: University of Minnesota

Sex: All·Age: 10 - 17

Code: NCT06194305·Phase 2·Recruiting

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IMPRoving Outcomes in Vascular DisEase - Aortic Dissection

for Type B Aortic Dissection

61 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT06087029·Recruiting

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Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)

for Hematologic Malignancy

5 locations incl. Duarte

Sponsor: Tr1X, Inc.

Sex: All·Age: 18+

Code: NCT06462365·Phase 1·Recruiting

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Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors

for Ovarian Cancer

17 locations incl. Duarte

Sponsor: Xencor, Inc.

Sex: All·Age: 15+

Code: NCT06276491·Phase 1·Recruiting

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A Study Evaluating the Safety and Efficacy of Inhaled AP01 in Participants With Progressive Pulmonary Fibrosis

for Pulmonary Fibrosis

59 locations incl. Birmingham

Sponsor: Avalyn Pharma Inc.

Sex: All·Age: 18+

Code: NCT06329401·Phase 2·Recruiting

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Microelectrode Recordings From the Vagus Nerve in Awake Humans

for Epilepsy

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06016686·Phase 1·Recruiting

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Determining the Effect of Six Weeks of Cannabis Abstinence on Fronto- Striatal fMRI Markers in Adolescents With Cannabis Use Disorder (ABSCAN)

for Cannabis Use Disorder

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 15 - 18·Accepts healthy volunteers

Code: NCT06124846·Recruiting

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Surgical Site Infections and the Microbiome: Understanding the Pathogenesis of Surgical Site Infections

for Open GI Surgery

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT06300892·Recruiting

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Normalizing Cervical Intersegmental Kinematics With Spinal Manipulative Therapy

for Neck Pain

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18 - 39

Code: NCT06312696·Recruiting

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Aim 3 Particle Swarm Optimization PIGD

for Parkinson's Disease and Parkinsonism

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18 - 85

Code: NCT05934747·Recruiting

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A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis

for Aortic Stenosis

Drug: Pelacarsen

37 locations incl. Huntsville

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 50 - 80

Code: NCT05646381·Phase 2·Recruiting

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Udall Project 1 Aim 4

for Parkinsons Disease

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 21+

Code: NCT05568199·Recruiting

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Evaluation of an Oral Microbiota-based Therapeutic as a Treatment Option for PSC

for Primary Sclerosing Cholangitis

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18 - 76

Code: NCT06197308·EARLY_Phase 1·Recruiting

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Modeling Tic Change During Behavior Therapy for Tics

for Chronic Tic Disorder

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 12 - 21

Code: NCT06270251·Recruiting

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DCIS: RECAST Trial Ductal Carcinoma In Situ: Re-Evaluating Conditions for Active Surveillance Suitability as Treatment

for Ductal Carcinoma in Situ

28 locations incl. Berkeley

Sponsor: QuantumLeap Healthcare Collaborative

Sex: Female·Age: 18+

Code: NCT06075953·Phase 2·Recruiting

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Trial of Neoadjuvant Enoblituzumab vs SOC in Men With High-Risk Localized Prostate Cancer

for Prostate Cancer

5 locations incl. Chicago

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: Male·Age: 18+

Code: NCT06014255·Phase 2·Recruiting

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RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

for Systemic Lupus Erythematosus

21 locations incl. Orange

Sponsor: Cabaletta Bio

Sex: All·Age: 18 - 65

Code: NCT06121297·Phase 1, Phase 2·Recruiting

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Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM Sleep Behavior Disorder

for Dementia With Lewy Bodies

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06467461·Recruiting

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A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis

for Antineutrophil Cytoplasmic Antibody-associated Vasculitis

60 locations incl. Anchorage

Sponsor: Amgen

Sex: All·Age: 18 - 100

Code: NCT06072482·Phase 4·Recruiting

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Intestinal Microbiota Transplantation in Patients Undergoing Colon Resection

for Recurrent Clostridioides Difficile Infection

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18 - 75

Code: NCT06370884·Phase 1·Recruiting

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Pancreatic Enzyme Replacement Therapy for Acute Pancreatitis-Associated Exocrine Pancreatic Insufficiency

for Exocrine Pancreatic Insufficiency

6 locations incl. Los Angeles

Sponsor: Ohio State University

Sex: All·Age: 18+

Code: NCT06477159·Phase 4·Recruiting

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A Study of Participants with Β-Thalassemia Treated with Betibeglogene Autotemcel

for Beta-Thalassemia

6 locations incl. Oakland

Sponsor: Genetix Biotherapeutics Inc.

Sex: All·Age: All ages

Code: NCT06271512·Recruiting

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A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide

for Multiple Myeloma

Drug: Talquetamab

49 locations incl. Clovis

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06208150·Phase 3·Recruiting

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To Investigate Airway Oxygen Concentrations During Rigid Bronchoscopy Procedures Performed With High Frequency Jet Ventilation

for Central Airway Obstruction

1 location in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT05881863·Recruiting

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National Liver Cancer Screening Trial

for Carcinoma, Hepatocellular

18 locations incl. Los Angeles

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 85

Code: NCT06084234·Phase 4·Recruiting

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RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS

for Epilepsy

5 locations incl. Stanford

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT06143293·Recruiting

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