Determining the Effect of Six Weeks of Cannabis Abstinence on Fronto- Striatal fMRI Markers in Adolescents With Cannabis Use Disorder (ABSCAN)

Part of paid clinical trials in Minneapolis, Minnesota.

Sponsor
University of Minnesota
Study ID
NCT06124846
Status
Recruiting
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Conditions

  • Cannabis Use Disorder

Eligibility Criteria

Sex
ALL
Age
15 Years - 18 Years
Healthy Volunteers
Accepted

Interventions

  • CB-Abst — BEHAVIORAL
    incentivized, biochemically verified abstinence via contingency management
  • CB-Mon — BEHAVIORAL
    monitoring with no required abstinence

Study Details

The goal of this study is to understand the changes in neural correlates of reward in adolescents with and without Cannabis Use Disorder (CUD). The study will collect functional magnetic resonance imaging (fMRI) data at 3 different timepoints with the primary goals of understanding striatal reward-based activation during a Monetary Incentive Delay Task and fronto-striatal fMRI resting-state functional connectivity. The study will also explore self-reported impulsivity. The long-term goal is to advance scientific understanding of neural changes associated with cannabis abstinence and inter-individual variability that cannot be otherwise measured in preexisting observational cohorts such as the Adolescent Brain Cognitive Development Study. This parallel intervention study will collect fMRI data in adolescents ages 15-18 years old with and without CUD at three different timepoints over the course of their intervention. Utilizing a validated paradigm, adolescents with CUD will be randomized to 6-weeks of either incentivized, biochemically verified abstinence via contingency management or monitoring with no required abstinence. Age- and sex-matched adolescents with no lifetime history of cannabis use will also complete the protocol. Participants will complete 9 study visits (3 with fMRI scans) involving urinalysis to confirm cannabis self-report and measures of impulsivity. Participants may additionally and optionally (1) complete daily remote self-report assessments of cannabis use, impulsivity, and mood throughout the 6-week treatment period, and (2) continue participation for an additional 6-week monitoring period after the treatment period, during which they complete daily remote self-report assessments of cannabis use, impulsivity, and mood.

Key Dates

Start date
Apr 1, 2024
Status verified
Apr 2026
Primary completion
Apr 15, 2028
Completion
Apr 15, 2028

Study Design

Enrollment
64 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • No Intervention: control
    Age- and sex-matched adolescents with no lifetime history of cannabis use will also complete the protocol.
  • Experimental: CB-Abst
    adolescents ages 15-18 years old with CUD use randomized to CB-Abst
  • Experimental: CB-MON
    adolescents ages 15-18 years old with CUD use randomized to CB-Mon

Primary Outcome Measure

Brain activation during Monetary Incentive Delay Task (reward processing) [ Time Frame: baseline, week3, week 6 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MinnesotaMinneapolisMinnesota55414
Chris Madden
[email protected]

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By research site
University of Minnesota· Minneapolis, MN

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