SV2 PET Imaging With [11C]APP311

Part of paid clinical trials in New Haven, Connecticut.

Sponsor
Yale University
Study ID
NCT03995121
Status
Recruiting
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Conditions

  • Cannabis Use Disorder
  • Healthy
  • Schizophrenia and Other Psychotic Disorders

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • [11C]APP311 — DRUG
    It has been shown that radiotracer \[11C\]APP311 (aka \[11C\]UCB-J) displays high specificity and selectivity for the synaptic vesicle protein SV2A. Since this protein is expressed ubiquitously in active synapses, this tracer has the potential to be a general purpose tool for quantitative imaging of synaptic density.

Study Details

The aim of this study is to evaluate a new SV2A tracer, \[11C\]APP311, in healthy aging and neuropsychiatric disorders including psychotic disorders and cannabis use disorders.

Key Dates

Start date
Dec 1, 2017
Status verified
Jan 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
250 participants (estimated)

Arms

  • Arm: Schizophrenia and other psychotic disorders
    For each \[11C\]APP311 PET scan, up to 20 mCi of \[11C\]APP311 will be administered by infusion pump, followed by up to 120 minutes of dynamic PET data acquisition.
  • Arm: Cannabis Use Disorder
    For each \[11C\]APP311 PET scan, up to 20 mCi of \[11C\]APP311 will be administered by infusion pump, followed by up to 120 minutes of dynamic PET data acquisition.
  • Arm: Healthy Control
    For each \[11C\]APP311 PET scan, up to 20 mCi of \[11C\]APP311 will be administered by infusion pump, followed by up to 120 minutes of dynamic PET data acquisition.

Primary Outcome Measure

Synaptic density in psychiatric disorders using SV2A receptor PET Imaging with [11C]APP311 [ Time Frame: One test day (one time point). ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Conneticut Mental Health CenterNew HavenConnecticut06519
Deepak C D'Souza, MD
[email protected]
203-932-5711

Find similar trials in New Haven, CT

By research site
Conneticut Mental Health Center· New Haven, CT

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