The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV

Part of paid clinical trials in Miami, Florida.

Sponsor
University of Miami
Study ID
NCT05453513
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 59 Years
Healthy Volunteers
Not accepted

Interventions

  • MRI Study — BEHAVIORAL
    fMRI Tasks

Study Details

To elucidate mechanisms of substance use disorders (SUD) and comorbid mental illnesses in people living with HIV (PLWH), the study team seeks to investigate reward and pain circuitry in cannabis use and depression comorbidity, two highly prevalent conditions in PLWH. The study team proposes a tightly integrative study to test the overall hypothesis that cannabis use and depression in young PLWH have an additive effect, inducing both reward deficits and pain hypersensitivity, and that this pattern will predict worse outcomes at 1 year follow-up.

Key Dates

Start date
Apr 1, 2022
Status verified
May 2025
Primary completion
Jul 30, 2027
Completion
Jul 30, 2027

Study Design

Enrollment
280 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Neural Underpinnings of Depression Group
    All participants will undergo neuroimaging and behavioral tests. during the course of the study (12 months).

Primary Outcome Measure

Addiction Severity Index (ASI) [ Time Frame: Up to 1 year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MiamiMiamiFlorida33136
Jasmine Agreda, BS
[email protected]
305-243-5510
Joanna Starrels, MD (SUB_INVESTIGATOR)
Anjali Sharma, MD (SUB_INVESTIGATOR)
Vilma Gabbay, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Miami, FL

By condition
DepressionHIV
By specialty
PsychiatryMental healthBehavioral healthInfectious disease
By research site
University of Miami· Miami, FL

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