Somatic Mosaicism in Twins Discordant for Childhood Cancer

Part of paid clinical trials in Minneapolis, Minnesota.

Sponsor
Children's Oncology Group
Study ID
NCT06054295
Status
Recruiting
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Conditions

  • Central Nervous System Tumor
  • Discordant Twin
  • Pediatric Central Nervous System Tumor
  • Somatic Mutation

Eligibility Criteria

Sex
ALL
Age
N/A - 18 Years
Healthy Volunteers
Not accepted

Interventions

  • Biospecimen collection — OTHER
    Collection of both blood and saliva samples from participants at the time of study enrollment
  • Questionnaire Administration — OTHER
    The brief questionnaire will assess health history, demographics, environmental exposures, family history of cancer, and birth characteristics.

Study Details

Somatic mosaicism in cancer associated genes is one potential explanation for discordance in childhood cancer that has not been fully explored to date. This pilot study will focus on twins with central nervous system (CNS) tumors who are identified through the Children's Oncology Group's Project: EveryChild (PEC) registry or volunteer.

Key Dates

Start date
Jun 3, 2024
Status verified
Dec 2025
Primary completion
Jun 30, 2026
Completion
Jun 30, 2027

Study Design

Enrollment
50 participants (estimated)

Arms

  • Arm: Ancillary-Correlative
    Twins with CNS tumors, identified through the Children's Oncology Group's Project:EveryChild (PEC) registry, will have both blood and saliva samples collected at the time of study enrollment.

Primary Outcome Measure

Compare the prevalence of somatic mosaicism in classic cancer-associated genes in monozygotic (MZ) twins discordant for childhood brain tumors. [ Time Frame: Up to 18 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MinnesotaMinneapolisMinnesota55455
Jenny Poynter, PhD
[email protected]
612-625-4232

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By research site
University of Minnesota· Minneapolis, MN

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