Heart disease Clinical Trials in Minneapolis, MN
As of June 2026, 42 paid clinical trials are recruiting for Heart disease in Minneapolis, Minnesota. Heart disease research tests new drug therapies, device-based interventions, and lifestyle programs for heart failure, atrial fibrillation, hypertension, and coronary disease — including therapies that reduce hospitalization and cardiovascular death. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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42 clinical trials for Heart disease
·Clear filters·↓ Download CSVPivotal Trial to Evaluate the Safety and Effectiveness of the P&F TricValve® Transcatheter Bicaval Valve System
INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery
HOPE-BP 2.0: Evaluating the Optimal Duration of Postpartum Remote Blood Pressure Monitoring
A Prospective, Multicenter, Randomized Controlled Trial to Investigate the Value of Coronary CT Angiography in the Understanding and Management of Coronary Calcium (The Optimal Trial)
CCM OPEN HF Registry
Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
Alleviant ALLAY-HFrEF Study
Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates 2.0
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
Effect of Empagliflozin on Left Atrial Function in Adults at Risk for Heart Failure
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
The TRICURE EFS Study
A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)
PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm
A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
SELUTION 4 De Novo Small Vessel IDE Trial
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation
A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
Alleviant ALLAY-HF Study
HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry
Assessment of CCM in HF With Higher Ejection Fraction
Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement
Progress Complication
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
Progress Bifurcation Global Registry
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
About research studies in Minneapolis
Minneapolis has approximately 974 recruiting research studies across a wide range of therapeutic areas. Minnesota is anchored by Mayo Clinic in Rochester and University of Minnesota Medical Center — nationally ranked for cancer, cardiology, and rare-disease research.
Top Research Study Locations in Minneapolis
Researchers run research studies in Minneapolis, MN at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Minnesota | Parkinson Disease, Depression, Epilepsy | 326 |
| Abbott-Northwestern Hospital | Acute Myeloid Leukemia, Stage IV Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8 | 90 |
| Hennepin County Medical Center | Malignant Solid Neoplasm, Stage IV Renal Cell Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8 | 82 |
| University of Minnesota/Masonic Cancer Center | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Malignant Solid Neoplasm | 44 |
| Health Partners Inc | Stage IVB Prostate Cancer AJCC v8, Malignant Solid Neoplasm, Stage IIIB Lung Cancer AJCC v8 | 41 |
| Minneapolis Heart Institute Foundation | Coronary Artery Disease, Heart Failure, Cardiovascular Diseases | 30 |
| Minneapolis VA Health Care System, Minneapolis, MN | Amputation, Bipolar Disorder, Spinal Cord Diseases | 29 |
| Children's Hospitals and Clinics of Minnesota - Minneapolis | Malignant Solid Neoplasm, Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia | 27 |
| University of Minnesota Medical Center | Aortic Stenosis, Von Willebrand Disease, Type 3, ADA SCID | 17 |
| Minneapolis Heart Institute | Aortic Stenosis, Cardiovascular Diseases, Coronary Artery Disease | 15 |
| Minneapolis VA Medical Center | Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8 | 14 |
| Masonic Cancer Center | Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Adenocarcinoma of Pancreas | 13 |
| Abbott Northwestern Hospital | AMI, Acute Myocardial Infarction (AMI), Acute Stroke | 11 |
| Minneapolis VA Health Care System | Heart Failure, Aging Related Cognitive Decline, Atherosclerotic Cardiovascular Disease in Patients With ESKD | 11 |
| University of Minnesota Medical School | Niemann-Pick Type C Disease, Advanced Solid Tumor, Alopecia | 11 |
| Children's Hospitals and Clinics of Minnesota | Cystic Fibrosis, B-cell Acute Lymphoblastic Leukemia, Caregiver Burden | 10 |
| Masonic Cancer Center, University of Minnesota | Adenocarcinoma of Lung, Alcohol-Related Carcinoma, Colo-rectal Cancer | 9 |
| Children's Hospital and Clinics of Minnesota | Neuroblastoma, ALL, AML | 8 |
| M Health Fairview University of Minnesota Medical Center | Ischemic Stroke, Prostate Cancer, Adamantinomatous Craniopharyngioma | 8 |
| Hennepin Healthcare Research Institute | Acute Compartment Syndrome, Aging, Atrial Fibrillation | 7 |
| Masonic Cancer Center at University of Minnesota | Myelodysplastic Syndromes, Acute Leukemia, Acute Myeloid Leukemia | 7 |
| University of Minnesota Masonic Children's Hospital | Chronic Hepatitis B, Fabry Disease, Hypochondroplasia | 7 |
| Children's Minnesota | ALK Fusion-positive Solid or CNS Tumors, Ciliary Body Medulloepithelioma, Craniopharyngioma | 6 |
| Hennepin Healthcare | Acute Respiratory Failure, Awareness, Carcinoma, Hepatocellular | 6 |
| Allina Health | ASCVD, Acute Limb Ischemia, Acute Stroke | 5 |
Active & Upcoming Studies in Minneapolis (2026)
Recruiting trials in Minneapolis grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (269 active studies)
- ICARE-LCS QUERI Partnered Evaluation Initiative: Integrating Comprehensive Tobacco Treatment to Enhance Lung Cancer Screening · VA Office of Research and Development
- A Study to Find the Highest Dose of Cedazuridine and Decitabine Combination With Filgrastim as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With High-Risk Acute Myeloid Leukemia · Phase 1 · National Cancer Institute (NCI)
Cardiovascular (70 active studies)
Neurology & pain (58 active studies)
- A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy · Phase 4 · Genentech, Inc.
- R01_Pilot Jaw Muscle Phenotypes · University of Minnesota
Diabetes & metabolic (39 active studies)
- SGLT2i Therapy in Islet Transplantation (SIT) · Phase 4 · University of Minnesota
- Reducing Risk of Diabetic Ketoacidosis in Type 1 Diabetes and Kidney Disease Using Continuous Ketone Monitoring · Phase 2 · HealthPartners Institute
Mental health & behavior (29 active studies)
- ICARE-LCS QUERI Partnered Evaluation Initiative: Integrating Comprehensive Tobacco Treatment to Enhance Lung Cancer Screening · VA Office of Research and Development
- Varenicline for Smoking Reduction in Veterans Not Ready To Quit · Phase 4 · VA Office of Research and Development
Pediatric (16 active studies)
- Magnesium Sulfate in Pediatric Burn Dressing Changes · Phase 1 · Hennepin Healthcare Research Institute
- Optimizing Pain Treatment in Children On Mechanical Ventilation · Phase 3 · Weill Medical College of Cornell University
HIV / STI (8 active studies)
- Combating HIV Stigma in Healthcare Settings: A Standardized Patient Approach · University of Minnesota
- Optimizing Medications and Lung Health in People With HIV Through Pharmacist-led Proactive E-Consults · Seattle Institute for Biomedical and Clinical Research
Eye & vision (6 active studies)
- Phase 4 Study: Long-term Safety and Efficacy of NT-501 in MacTel Type 2, Including Sham Procedure Participants · Phase 4 · Neurotech Pharmaceuticals
- A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma · Phase 3 · AbbVie
Vaccines (5 active studies)
- H1ssF Flu Vaccine Clinical Trial · Phase 1 · University of Minnesota
- A Study to Evaluate Safety and Efficacy of TP-05 in Healthy Participants With Tick Exposure · Phase 2 · Tarsus Pharmaceuticals, Inc.
Common conditions studied in Minneapolis
- Heart Failure (18 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Acute Myeloid Leukemia (16 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.
- Breast Cancer (14 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Parkinson Disease (14 active studies). Parkinson's disease studies evaluate disease-modifying therapies, gene therapies, and advanced symptomatic treatments for motor and non-motor symptoms.
- Endometrial Cancer (12 active studies). Recruiting Endometrial Cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Ovarian Cancer (11 active studies). Ovarian cancer research examines PARP inhibitors, maintenance therapies, and antibody-drug conjugates for recurrent and platinum-resistant disease.
Leading research sponsors in Minneapolis
- University of Minnesota
- National Cancer Institute (NCI)
- Masonic Cancer Center, University of Minnesota
- VA Office of Research and Development
- Children's Oncology Group
Local regulations and guidelines
Clinical trials in Minnesota are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Minnesota research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Minneapolis. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Minneapolis
Hipa.ai aggregates every recruiting study in Minneapolis from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Minneapolis?
There are approximately 974 recruiting clinical trials in Minneapolis, Minnesota listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Minneapolis pay participants?
Most recruiting trials in Minneapolis compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Minneapolis?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Minneapolis?
The most common conditions under active study in Minneapolis include Heart Failure (18), Acute Myeloid Leukemia (16), Breast Cancer (14), Parkinson Disease (14), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Minneapolis?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Minneapolis on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Minneapolis?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Minneapolis?
Recruiting research sites in Minneapolis include University of Minnesota, Abbott-Northwestern Hospital, Hennepin County Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Minneapolis right now?
The largest active categories in Minneapolis are Cancer & tumors (269), Cardiovascular (70), Neurology & pain (58). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.