Paid Clinical Trials in Saint Paul, MN
As of June 2026, 190 paid clinical trials are recruiting in Saint Paul, Minnesota. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Saint Paul offers studies at sites including Regions Hospital for conditions such as Acute Myeloid Leukemia, Stage IV Lung Cancer AJCC v8, Breast Cancer, Melanoma. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Saint Paul
Trials by drug in Saint Paul
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190 clinical trials
↓ Download CSVThe Effect of the Safe and Sound Protocol on Depression and Anxiety Symptoms
Evaluate the Effect of Vimseltinib on Pharmacokinetics of Combined Oral Contraceptive (Ethinyl Estradiol/Levonorgestrel)
Proof of Concept Study of Vaginal AZU-101 in Vulvovaginal Atrophy in Postmenopausal Women
Respiration Measured Via End-tidal CO2 and Spirometry Study (RESPI)
A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies
Establishing the Preliminary Utility of a Novel Pediatric Manual Mobile Standing Wheelchair
Mindfulness-Based Stress Reduction for Emotional Recovery After Stroke
Axelopran for Advanced Cancer in Patients Receiving Opioids
A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
Safety and Feasibility of Intranasal Insulin in Patients With Spinal Cord Injury
A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer
Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
A Trial to Investigate Safety, Exposure, and Efficacy of HU6 Compared With Placebo in Adult Participants With Metabolic Dysfunction-associated Steatohepatitis (MASH)
A Study to Learn How the Body Processes the Study Medicine PF-07328948 in People With Reduced Kidney Function
Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancer
Surgical Thromboprophylaxis Practices in Oncology Patients Within the NCORP Network, STOP-VTE Study
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
Trial Investigating the Efficacy and Safety of Weekly Lonapegsomatropin Compared to Daily Somatropin in Children and Adolescents With Short Stature or Growth Failure Due to Growth Hormone Sufficient Disorders
Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer
A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitean-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)
Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.
Observational Study of VYKAT™ XR in Patients With Prader-Willi Syndrome
Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study
Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756)
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
Irrigating vs Traditional Negative Pressure Wound Therapy to Treat Necrotizing Soft Tissue Infections
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-2)
A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
TMS in Anxiety-Parkinson's Disease
Pilot TMS in Mild TBI
Balance4Mobility: Effects of Walkasins Use in Individuals With Peripheral Neuropathy and Balance Problems
Phase 1/2 Study of ABO-101 in Primary Hyperoxaluria Type 1 (redePHine)
The AIRTIVITY™ Study: A Study to Find Out Whether BI 1291583 Helps People With Bronchiectasis
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of Creatinine in a Non Interventional Cohort
About research studies in Saint Paul
Saint Paul has approximately 190 recruiting research studies across a wide range of therapeutic areas. Minnesota is anchored by Mayo Clinic in Rochester and University of Minnesota Medical Center — nationally ranked for cancer, cardiology, and rare-disease research.
Top Research Study Locations in Saint Paul
Researchers run research studies in Saint Paul, MN at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Regions Hospital | Acute Myeloid Leukemia, Stage IV Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8 | 108 |
| United Hospital | Acute Myeloid Leukemia, Stage IV Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8 | 88 |
| HealthPartners Neuroscience Center | Alzheimer Disease, Alzheimer's Disease, Anxiety | 9 |
| Gillette Children's Specialty Healthcare | Cerebral Palsy, Chronic Post Surgical Pain, Fracture Distal Radius | 8 |
| Children's Minnesota | Hypothalamic Obesity, Prader-Willi Syndrome, Childhood-onset Combined Pituitary Hormone Deficiency | 5 |
| HealthPartners Cancer Center at Regions Hospital | 1st Line NSCLC, Advanced Solid Tumor, Breast Cancer | 5 |
| HealthPartners Cancer Research Center | Advanced Solid Tumors, Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis | 4 |
| Nucleus Network | Healthy, Healthy Participants, Primary Hyperoxaluria Type 1 (PH1) | 4 |
| Allina Health Cancer Institute - United Hospital | Advanced Hepatocellular Carcinoma, Carcinoma, Hepatocellular, Hepatocellular Cancer | 2 |
| Ascendis Investigational Site | Achondroplasia | 2 |
| Regions Hospital Pharmacy | Advanced or Metastatic Solid Tumors, Brain Neoplasms, Differentiated Thyroid Cancer | 2 |
| Ain Dah Yung Center | Mental Health Wellness 1, Parenting, Risky Health Behavior | 1 |
| Allina Health Cancer Institute | Carcinoma, Non-Small Cell Lung, Cutaneous Squamous Cell Cancer, Esophageal Adenocarcinoma | 1 |
| Allina Health Cancer Institute-United(VPCI) | Colorectal Neoplasms | 1 |
| Ascendis Pharma Investigational Site | Idiopathic Short Stature, Short Stature Homeobox Gene Mutation, Small for Gestational Age at Delivery | 1 |
| Boston Scientific Arden Hills | Respiration Rate Detection | 1 |
| Children's Hospitals and Clinics of Minnesota | Failed or Difficult Intubation, Sequela, Intubation Complication, Intubation; Difficult | 1 |
| Children's Minnesota - Children's Hospital and Clinics | Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity, Intraventricular Hemorrhage | 1 |
| Children's Minnesota - Children's Hospital and Clinics - St. Paul | Bronchopulmonary Dysplasia, Chronic Lung Disease of Prematurity, Intraventricular Hemorrhage | 1 |
| Clinical Study Site | Non-Small Cell Lung Cancer | 1 |
| Fairview Frontiers | Balance Control in Elderly, Gait Disorders, Peripheral Neuropathies | 1 |
| Gillette Children's | Cerebral Palsy | 1 |
| Gillette Children's Specialty Health | Failed or Difficult Intubation, Sequela, Intubation Complication, Intubation; Difficult | 1 |
| Health Partners - Regions Hospital | Ductal Carcinoma in Situ | 1 |
| Health Partners Cancer Center at Regions Hospital | Advanced Solid Tumor, Bladder Cancer, Breast Cancer | 1 |
Active & Upcoming Studies in Saint Paul (2026)
Recruiting trials in Saint Paul grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (109 active studies)
- Axelopran for Advanced Cancer in Patients Receiving Opioids · Phase 2 · HealthPartners Institute
- A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201) · Phase 3 · Bristol-Myers Squibb
Neurology & pain (7 active studies)
- Mindfulness-Based Stress Reduction for Emotional Recovery After Stroke · HealthPartners Institute
- A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3) · Phase 3 · Bristol-Myers Squibb
Mental health & behavior (4 active studies)
- The Effect of the Safe and Sound Protocol on Depression and Anxiety Symptoms · HealthPartners Institute
- TMS in Anxiety-Parkinson's Disease · HealthPartners Institute
Diabetes & metabolic (4 active studies)
- A Trial of Setmelanotide in Patients With Congenital Hypothalamic Obesity (Sub-study of NCT05774756) · Phase 3 · Rhythm Pharmaceuticals, Inc.
- Balance4Mobility: Effects of Walkasins Use in Individuals With Peripheral Neuropathy and Balance Problems · RxFunction Inc.
Cardiovascular (4 active studies)
- A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart · Phase 3 · Boehringer Ingelheim
- Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function · Phase 3 · AstraZeneca
Common conditions studied in Saint Paul
- Acute Myeloid Leukemia (6 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.
- Stage IV Lung Cancer AJCC v8 (6 active studies). Lung cancer research focuses on targeted therapies for specific mutations such as EGFR, ALK, and KRAS, alongside immunotherapy regimens.
- Breast Cancer (5 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Melanoma (5 active studies). Melanoma trials test immune checkpoint inhibitors, adoptive cell therapies, and BRAF/MEK targeted combinations in both early and metastatic disease.
- Stage IIIB Lung Cancer AJCC v8 (5 active studies). Lung cancer research focuses on targeted therapies for specific mutations such as EGFR, ALK, and KRAS, alongside immunotherapy regimens.
- Alzheimer Disease (4 active studies). Alzheimer's research investigates anti-amyloid antibodies, tau-targeted therapies, and lifestyle interventions aimed at slowing cognitive decline.
Leading research sponsors in Saint Paul
- National Cancer Institute (NCI)
- SWOG Cancer Research Network
- NRG Oncology
- Alliance for Clinical Trials in Oncology
- HealthPartners Institute
Local regulations and guidelines
Clinical trials in Minnesota are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Minnesota research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Saint Paul. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Saint Paul
Hipa.ai aggregates every recruiting study in Saint Paul from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Saint Paul?
There are approximately 190 recruiting clinical trials in Saint Paul, Minnesota listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Saint Paul pay participants?
Most recruiting trials in Saint Paul compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Saint Paul?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Saint Paul?
The most common conditions under active study in Saint Paul include Acute Myeloid Leukemia (6), Stage IV Lung Cancer AJCC v8 (6), Breast Cancer (5), Melanoma (5), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Saint Paul?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Saint Paul on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Saint Paul?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Saint Paul?
Recruiting research sites in Saint Paul include Regions Hospital, United Hospital, HealthPartners Neuroscience Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Saint Paul right now?
The largest active categories in Saint Paul are Cancer & tumors (109), Neurology & pain (7), Mental health & behavior (4). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.