Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women

Part of paid clinical trials in Minneapolis, Minnesota.

Sponsor
University of Minnesota
Study ID
NCT04439370
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
FEMALE
Age
35 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Microneurography to measure muscle sympathetic nerve activity (MSNA) — DIAGNOSTIC_TEST
    Microneurography is a direct measurement of electrical activity of peripheral sympathetic nerves
  • Baroreflex sensitivity testing — DIAGNOSTIC_TEST
    Two arms of the baroreflex that will be tested in this study are sympathetic and cardiovagal. Static baroreflex is tested during baseline resting conditions and dynamic baroreflex is tested during Valsalva maneuvers.
  • Sympathoexcitatory Maneuvers — DIAGNOSTIC_TEST
    Cold Pressor Test (CPT) and Upper extremity fatiguing contraction with post exercise circulatory occlusion (PECO) will be performed
  • Blood tests — DIAGNOSTIC_TEST
    Serum FSH, estrogen, progesterone, and testosterone will be measured

Study Details

This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one and aim two.

Key Dates

Start date
Oct 1, 2019
Status verified
Jan 2026
Primary completion
Dec 30, 2026
Completion
Dec 30, 2026

Study Design

Enrollment
160 participants (estimated)

Arms

  • Arm: Aim 1: Postmenopausal Women
    Participants in this group are postmenopausal women.
  • Arm: Aim 1: Premenopausal Women
    Participants in this group are premenopausal women.
  • Arm: Aim 2: Premature/Early Menopause
    Participants in this group women who experienced premature or early menopause.
  • Arm: Aim 2: Typical-Age Menopause
    Participants in this group are women who experienced menopause at a typical age.

Primary Outcome Measure

Muscle Sympathetic Nerve Activity (MSNA) (bursts per minute) [ Time Frame: 3 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MinnesotaMinneapolisMinnesota55455
Manda Keller-Ross, PhD, DPT, PT
[email protected]
612-625-3175

Find similar trials in Minneapolis, MN

By condition
Hypertension (high blood pressure)Menopause
By specialty
CardiologyHeart diseaseWomen's healthFertility
By research site
University of Minnesota· Minneapolis, MN

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