Paid Clinical Trials in Massachusetts

Massachusetts has 3,584 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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3,586 clinical trials

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Early Internal Fixation Versus NonOperative Care With Early Rehabilitation for LC1 Fragility Fractures of the Pelvis

for Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring

12 locations incl. Phoenix

Sponsor: University of Southern California

Sex: All·Age: 60+

Code: NCT06496867·Recruiting

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Multicenter Symphony IL-6 Monitoring Sepsis ICU Validation Study

for Sepsis, Septic Shock

5 locations incl. Gainesville

Sponsor: Bluejay Diagnostics, Inc.

Sex: All·Age: 22+

Code: NCT06654895·Recruiting

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Xeltis Hemodialysis Access Graft (aXess) US Study

for End Stage Renal Disease

7 locations incl. Phoenix

Sponsor: Xeltis

Sex: All·Age: 18+

Code: NCT06494631·Enrolling By Invitation

Long Term Follow-up Study of AAVAnc80-hOTOF Gene Therapy

for Otoferlin Gene-mediated Hearing Loss

3 locations incl. Iowa City

Sponsor: Akouos, Inc.

Sex: All·Age: All ages

Code: NCT06696456·Enrolling By Invitation

A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)

for Developmental and Epileptic Encephalopathy

31 locations incl. Little Rock

Sponsor: Longboard Pharmaceuticals

Sex: All·Age: 2 - 65

Code: NCT06719141·Phase 3·Recruiting

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The Effect of PROSE or Scleral Lenses on Mental Health

for Depression - Major Depressive Disorder

1 location in Needham

Sponsor: Boston Sight

Sex: All·Age: All ages

Code: NCT07195721·Recruiting

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Eating to Adjust the Timing System

for Dietary Intervention

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05800990·Recruiting

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Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

for Heart Failure

6 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT06517186·Recruiting

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Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU

for Consciousness Disorders

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06568536·Recruiting

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Anti-GD2 ADC M3554 in Advanced Solid Tumors

for Advanced Solid Tumor

3 locations incl. Boston

Sponsor: EMD Serono Research & Development Institute, Inc.

Sex: All·Age: 18+

Code: NCT06641908·Phase 1·Recruiting

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A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT)

for Hereditary Hemorrhagic Telangiectasia

8 locations incl. Birmingham

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06659640·Phase 1, Phase 2·Recruiting

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Efficacy and Safety of Leadless Pacemakers Versus Left Bundle Area Pacing - A Preliminary Exploration

for Pacemaker Implantation

2 locations incl. Naples

Sponsor: NCH Healthcare System, Inc. dba Naples Comprehensive Health and dba NCH

Sex: All·Age: 18+

Code: NCT06690333·Recruiting

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A Non-interventional, Post-authorisation Safety Study of Patients Treated With Efgartigimod Alfa

for Myasthenia Gravis

17 locations incl. San Francisco

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT06298565·Recruiting

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PULSED AF Post-Approval Study

for Atrial Fibrillation

18 locations incl. Tampa

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18+

Code: NCT06578104·Recruiting

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Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty

for Cardiovascular Diseases

2 locations incl. Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06244199·Recruiting

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Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study

for Chronic Subdural Hematoma

31 locations incl. Phoenix

Sponsor: The University of Texas Medical Branch, Galveston

Sex: All·Age: 40 - 90

Code: NCT06347796·Recruiting

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A Study of Toripalimab in Combination With Cisplatin and Gemcitabine in Participants With Recurrent Metastatic Nasopharyngeal Cancer

for Nasopharyngeal Cancer Recurrent

12 locations incl. Little Rock

Sponsor: Coherus Oncology, Inc.

Sex: All·Age: 12+

Code: NCT06457503·Phase 4·Recruiting

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Elotuzumab + Iberdomide + Dexamethasone Post Ide-Cel in RRMM

for Myeloma

Drug: Iberdomide

3 locations incl. Boston

Sponsor: Omar Nadeem, MD

Sex: All·Age: 18+

Code: NCT06518551·Phase 1, Phase 2·Recruiting

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Elranatamab in Patients With Relapsed or Refractory AL Amyloidosis

for AL Amyloidosis

Drug: Elranatamab

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06569147·Phase 1, Phase 2·Recruiting

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Influences of Long-acting Reversible Contraceptives on Iron Status and Physiological Responses to Extreme Environments in Women

for Contraception

1 location in Natick

Sponsor: United States Army Research Institute of Environmental Medicine

Sex: Female·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06909695·Recruiting

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Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

for Diabetic Nephropathies

Drug: Sotagliflozin

13 locations incl. Stanford

Sponsor: Alessandro Doria

Sex: All·Age: 18 - 75

Code: NCT06217302·Phase 3·Recruiting

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Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis

for Congenital Heart Disease

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 1 Day - 7 Days

Code: NCT06434207·Recruiting

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Barrigel® PPRT (Post-Prostatectomy Radiation Therapy) Trial

for Prostate Cancer

4 locations incl. Boston

Sponsor: Palette Life Sciences, Inc.

Sex: Male·Age: 18+

Code: NCT06496256·Recruiting

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Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease

for Moderately to Severely Active Crohn Disease

43 locations incl. Fairhope

Sponsor: Abivax S.A.

Sex: All·Age: 18 - 75

Code: NCT06456593·Phase 2·Recruiting

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A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

for Age-related Macular Degeneration (AMD)

Drug: Cemdisiran

152 locations incl. Chandler

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 50 - 85

Code: NCT06541704·Phase 3·Recruiting

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The THOR IDE Study

for Peripheral Artery Disease

29 locations incl. St. Helena

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT05916950·Recruiting

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The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study

for Metastatic Breast Cancer

73 locations incl. Chandler

Sponsor: American Society of Clinical Oncology

Sex: All·Age: 65+

Code: NCT06377852·Phase 3·Recruiting

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TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd

for Breast Cancer

11 locations incl. Birmingham

Sponsor: Ana C Garrido-Castro, MD

Sex: All·Age: 18+

Code: NCT06533826·Phase 2·Recruiting

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Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

for Solid Tumor, Adult

19 locations incl. Duarte

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06625775·Phase 1·Recruiting

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Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Diffuse Cutaneous Systemic Sclerosis

for Scleroderma, Diffuse

14 locations incl. Los Angeles

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 70

Code: NCT06655896·Phase 2·Recruiting

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Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

for Cardiovascular Diseases

37 locations incl. Little Rock

Sponsor: BrioHealth Solutions, Inc.

Sex: All·Age: 18 - 100

Code: NCT06310031·Recruiting

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Psychoeducational Intervention for Patients With Hepatocellular Carcinoma

for Hepatocellular Carcinoma

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06541990·Recruiting

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A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer

for Advanced Breast Cancer

35 locations incl. Springdale

Sponsor: Stemline Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06638307·Phase 1·Recruiting

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Effect of Support for Low-Income Mothers of Preterm Infants

for Preterm Birth

4 locations incl. Atlanta

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 18+

Code: NCT06362798·Recruiting

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A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)

for Healthy Volunteers, Pulmonary Arterial Hypertension

19 locations incl. Scottsdale

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06649110·Phase 1, Phase 2·Recruiting

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Ablation-Index Guided Scar-Mediated Ventricular Tachycardia Ablation in Patients With Ischemic Cardiomyopathy

for Ventricular Tachycardia

5 locations incl. Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT06138873·Recruiting

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A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)

for Primary Myelofibrosis

13 locations incl. Palo Alto

Sponsor: Ajax Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06343805·Phase 1·Recruiting

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Shoulder Innovations Clinical Data Registry

for Shoulder Arthroplasty

8 locations incl. Birmingham

Sponsor: Shoulder Innovations

Sex: All·Age: 18+

Code: NCT06754150·Recruiting

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A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

for Basal Ganglia Germinoma

92 locations incl. Mobile

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT06368817·Phase 2·Recruiting

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Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age

for Amblyopia

58 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 8 - 12

Code: NCT06524882·Phase 3·Recruiting

Apply to this trial