Paid Clinical Trials in Massachusetts

Massachusetts has 3,584 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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3,586 clinical trials

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A Study to Assess the Efficacy and Safety of ITI-1284 in the Treatment of Agitation Associated With Alzheimer's Dementia

for Agitation Associated With Alzheimer's Dementia

30 locations incl. Anaheim

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 55+

Code: NCT06651567·Phase 2·Recruiting

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ATTUNE: A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Participants With Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome (MDS)

for Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome

8 locations incl. San Diego

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: Male·Age: 2 - 65

Code: NCT06430385·Phase 1, Phase 2·Recruiting

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Novel Digital Application for Patients With Acute Leukemia

for Relapsed Adult Acute Myeloid Leukemia

3 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 120

Code: NCT06472128·Recruiting

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Supportive Care Intervention for Outpatient Stem Cell Transplant Patients

for Hematopoietic Stem Cell Transplantation

1 location in Boston

Sponsor: Victor Wang

Sex: All·Age: 19+

Code: NCT06564233·Recruiting

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A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

for Carcinoma, Non-Small-Cell Lung

Drug: Intismeran autogene

48 locations incl. Gilbert

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06623422·Phase 3·Recruiting

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Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID

for Long COVID

Drug: Baricitinib

17 locations incl. Tucson

Sponsor: Wes Ely

Sex: All·Age: 18+

Code: NCT06631287·Phase 3·Recruiting

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Pembrolizumab + Chemotherapy in Newly Diagnosed PCNSL

for Lymphoma

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06475235·Phase 1·Recruiting

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J-Valve Transfemoral Pivotal Study

for Aortic Valve Regurgitation

34 locations incl. Scottsdale

Sponsor: JC Medical, Inc., an affiliate of Edwards Lifesciences LLC

Sex: All·Age: 18+

Code: NCT06455787·Recruiting

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THRIVE-CAR-T Digital App

for CAR T-Cell Therapy

1 location in Boston

Sponsor: Patrick C. Johnson, MD

Sex: All·Age: 18+

Code: NCT06665295·Recruiting

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Vaginal Photobiomodulation for Chronic Pelvic Pain

for Chronic Pelvic Pain

5 locations incl. Birmingham

Sponsor: SoLa Pelvic Therapy

Sex: Female·Age: 18+

Code: NCT06673108·Phase 2·Recruiting

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Mechanisms of Exposure Therapy for OCD

for Obsessive-Compulsive Disorder

2 locations incl. San Diego

Sponsor: Mclean Hospital

Sex: All·Age: 18 - 65

Code: NCT06173752·Recruiting

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A Comparative Clinical Study to Assess Pain Score and Wound Healing Following Fractional Ablation With a DFG Laser and CO2 Laser

for Healthy

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06295471·Recruiting

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A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating AMG 691 in Healthy Participants and Participants With Mild-to-Moderate Asthma

for Asthma

15 locations incl. Lake Forest

Sponsor: Amgen

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06637371·Phase 1·Recruiting

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Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers

for Pancreatic Ductal Adenocarcinoma

10 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT06562192·Phase 1·Recruiting

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A Study Observing Everyday Effectiveness and Safety of the Drug Elafibranor in Participants With Primary Biliary Cholangitis Who Are Receiving Ongoing Treatment

for Primary Biliary Cholangitis

Drug: Elafibranor

20 locations incl. Coronado

Sponsor: Ipsen

Sex: All·Age: All ages

Code: NCT06447168·Recruiting

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Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)

for Liver Neoplasms

30 locations incl. Fullerton

Sponsor: HistoSonics, Inc.

Sex: All·Age: 22+

Code: NCT06486454·Recruiting

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Open-label Extension Study to Evaluate Metreleptin in Patients With Partial Lipodystrophy

for Familial Partial Lipodystrophy

7 locations incl. Birmingham

Sponsor: Amryt Pharma

Sex: All·Age: 13+

Code: NCT06679270·Phase 3·Recruiting

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Effect of Physical Activity Pattern on Cardiometabolic Health

for Life Style

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05838508·Recruiting

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Registry and Natural History Study for Progressive Myoclonus Epilepsy Type 1 (EPM1)

for Progressive Myoclonus Epilepsy Type 1

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: All ages

Code: NCT06593951·Recruiting

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A Study to Evaluate IPN10200 Safety and Efficacy in the Prevention of Episodic or Chronic Migraine in Adults

for Episodic Migraine

71 locations incl. Birmingham

Sponsor: Ipsen

Sex: All·Age: 18 - 80

Code: NCT06625060·Phase 2·Recruiting

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Intraperitoneal Cytokine-Induced Memory Like (CIML) Natural Killer (NK) Cells in Recurrent Ovarian Cancer

for Platinum-resistant Ovarian Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18 - 85

Code: NCT06321484·Phase 1·Recruiting

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Care Transitions App for Patients With Multiple Chronic Conditions

for Heart Failure

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT06051058·Recruiting

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Gluten Technology and Education for Celiac Health

for Celiac Disease

4 locations incl. Chicago

Sponsor: Columbia University

Sex: All·Age: 18 - 75

Code: NCT06059716·Recruiting

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The CurePSP Genetics Program

for PSP

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 35+·Accepts healthy volunteers

Code: NCT06647641·Recruiting

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Phase 1 Study of ACR-2316 in Specific Advanced Solid Tumors

for Specific Advanced Solid Tumors

15 locations incl. Phoenix

Sponsor: Acrivon Therapeutics

Sex: All·Age: 18+

Code: NCT06667141·Phase 1·Recruiting

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A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer

for Metastatic Non-small Cell Lung Cancer

Drug: Osimertinib

34 locations incl. Fayetteville

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06417814·Phase 3·Recruiting

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Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome

for Acute Respiratory Distress Syndrome

10 locations incl. Los Angeles

Sponsor: Children's Hospital Los Angeles

Sex: All·Age: 0 - 21

Code: NCT06690801·Recruiting

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REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities

for Coronary Artery Disease

18 locations incl. Glendale

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT06399705·Phase 3·Recruiting

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Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma

for Peripheral T-Cell Lymphoma, Not Otherwise Specified

Drug: Soquelitinib

21 locations incl. Duarte

Sponsor: Corvus Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06561048·Phase 3·Recruiting

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A Trial to Test if TEV-56286 is Effective for Treatment of Participants With Multiple System Atrophy

for Multiple System Atrophy

19 locations incl. La Jolla

Sponsor: Teva Branded Pharmaceutical Products R&D LLC

Sex: All·Age: 30 - 75

Code: NCT06568237·Phase 2·Recruiting

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Improving Health for Older Adults With Pain Through Engagement

for Chronic Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 55+

Code: NCT06119698·Recruiting

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Behavioral Economics to Implement a Traffic Light Nutrition Ranking System: Study 2

for Food Insecurity

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT06298253·Recruiting

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DISCOVERY of Risk Factors for Type 2 Diabetes in Youth

for Diabetes Mellitus Type 2, Childhood-Onset

20 locations incl. Birmingham

Sponsor: George Washington University

Sex: All·Age: 8 - 15

Code: NCT06525259·Recruiting

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Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy

for Diabetic Peripheral Neuropathic Pain

76 locations incl. Anniston

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 80

Code: NCT06628908·Phase 3·Recruiting

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Neural Control of Kidney Blood Flow During Exercise in African American Adults

for Healthy

1 location in Boston

Sponsor: University of Massachusetts, Boston

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT03981640·Recruiting

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Preterm Infants Fed a Human Milk Fortifier

for Growth

14 locations incl. Phoenix

Sponsor: Abbott Nutrition

Sex: All·Age: All ages

Code: NCT05551975·Not Yet Recruiting

Prevention of Injury in Skilled Nursing Facilities Through Optimizing Medications

for Accidental Falls/Prevention and Control

2 locations incl. Boston

Sponsor: Duke University

Sex: All·Age: 65+

Code: NCT06304428·Enrolling By Invitation

Phase III Presbyopia Correction Using the VIS Opti-K™ System

for Presbyopia

4 locations incl. Boca Raton

Sponsor: VIS, Inc.

Sex: All·Age: 40+

Code: NCT06487897·Phase 3·Recruiting

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A Study of GSK5764227 in Participants With Advanced Solid Tumors (EMBOLD)

for Neoplasms

15 locations incl. Stanford

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06551142·Phase 1·Recruiting

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Long-term Safety and Efficacy Evaluation of Lunsekimig (SAR443765) in Adult Participants With Asthma

for Asthma

Drug: Lunsekimig

27 locations incl. Chandler

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06609239·Phase 2·Enrolling By Invitation