Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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Hybrid Type I Effectiveness-Implementation Trial of a Social Network Support Intervention

for HIV Seropositivity

7 locations incl. Birmingham

Sponsor: University of Chicago

Sex: All·Age: 18 - 49·Accepts healthy volunteers

Code: NCT05723653·Recruiting

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SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer

for Oropharyngeal Cancer

26 locations incl. Corona

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT05451004·Phase 3·Recruiting

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Oral Statins and Protection From Hearing Loss

for Sudden Sensorineural Hearing Loss

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 80

Code: NCT04826237·Phase 4·Recruiting

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Testing Lutetium Lu 177 Dotatate in Patients With Somatostatin Receptor Positive Advanced Bronchial Neuroendocrine Tumors

for Advanced Lung Neuroendocrine Tumor

29 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04665739·Phase 2·Recruiting

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A Study to Follow Patients With Adult Growth Hormone Deficiency (AGHD) Treated With Sogroya® for Long Term Safety Information

for Adult Growth Hormone Deficiency

29 locations incl. Phoenix

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT05718570·Enrolling By Invitation

Study of Cabozantinib and Nivolumab in Metastatic Castration Resistant Prostate Cancer

for Castration-resistant Prostate Cancer

Drug: Cabozantinib

4 locations incl. La Jolla

Sponsor: Rana McKay, MD

Sex: Male·Age: 18+

Code: NCT05502315·Phase 2·Recruiting

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Sensitivity of the NIH Toolbox to Stimulant Treatment in Intellectual Disabilities

for Intellectual Disability

3 locations incl. Sacramento

Sponsor: University of California, Davis

Sex: All·Age: 6 - 24

Code: NCT05301361·Phase 1·Enrolling By Invitation

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

for Metastatic Renal Cell Carcinoma

313 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05327686·Phase 2·Recruiting

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Renal Mass Biopsy, PEER, and 99mTc-sestamibi SPECT/CT for Patients With Clinically Localized Renal Tumors

for Kidney Tumor

1 location in Maywood

Sponsor: Loyola University

Sex: All·Age: 18+

Code: NCT05728957·Recruiting

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mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

for Advanced Esophageal Adenocarcinoma

Drug: Nivolumab

785 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05677490·Phase 3·Recruiting

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MYLUNG Consortium Part 3: Observational Study

for Carcinoma, Non-Small-Cell Lung

17 locations incl. Daphne

Sponsor: US Oncology Research

Sex: All·Age: 18+

Code: NCT05885698·Recruiting

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A Real World Study of eCoin for Urgency Urinary Incontinence: Post Approval Evaluation (RECIPE)

for Overactive Bladder

22 locations incl. Homewood

Sponsor: Valencia Technologies Corporation

Sex: All·Age: 18+

Code: NCT05685433·Recruiting

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Spinal Cord Stimulation for Functional Recovery in Humans With Tetraplegia

for Spinal Cord Injury

2 locations incl. Chicago

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT05157282·Recruiting

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Study of Gastric Motility in Eosinophilic Gastritis

for Eosinophilic Gastritis

3 locations incl. Chicago

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 18 - 59

Code: NCT05229432·Recruiting

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GI Oxalate Absorption

for Bariatric Surgery Candidate

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70

Code: NCT05356000·Recruiting

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BEETroot Juice to Reverse Functional Impairment in PAD

for Peripheral Artery Disease

4 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT05624125·Recruiting

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Musculoskeletal and Pelvic Floor Health in Female Chronic Overlapping Pelvic Pain Conditions

for Chronic Pelvic Pain Syndrome

1 location in Maywood

Sponsor: Loyola University

Sex: Female·Age: 21 - 80

Code: NCT05750212·Recruiting

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Surveillance vs. Endoscopic Therapy for Barrett's Esophagus With Low-grade Dysplasia

for Barretts Esophagus With Dysplasia

23 locations incl. Los Angeles

Sponsor: University of Colorado, Denver

Sex: All·Age: 18 - 89

Code: NCT05753748·Recruiting

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A Study to See Iftolvaptan is Safe in Infants and Children Who at Enrollment Are 28 Days to Less Than 18 Years Old withAutosomal Recessive Polycystic Kidney Disease (ARPKD)

for Autosomal Recessive Polycystic Kidney (ARPKD)

12 locations incl. Washington D.C.

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 28 Days - 18

Code: NCT04782258·Phase 3·Recruiting

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ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)

for H3 K27M

67 locations incl. Phoenix

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: All ages

Code: NCT05580562·Phase 3·Recruiting

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Neural Prediction to Enhance Language

for Bilateral Sensorineural Hearing Loss

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 0 Months - 5

Code: NCT05962359·Recruiting

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Web-based Pain Coping Skills Training for Breast Cancer Survivors With AI-Associated Arthralgia

for Breast Cancer

2 locations incl. Chicago

Sponsor: Northwestern University

Sex: Female·Age: 18+

Code: NCT05703178·Phase 3·Recruiting

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Empowering Vulnerable and Resilient Latinas to Obtain Breast Cancer Care

for Breast Cancer

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: Female·Age: 30+

Code: NCT05483283·Recruiting

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Mastery Learning in Communication Skills

for Communication Research

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 20 - 60·Accepts healthy volunteers

Code: NCT05979090·Recruiting

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Combination Therapy to Improve SCI Recovery.

for Spinal Cord Injuries

2 locations incl. Chicago

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 70

Code: NCT05563103·Recruiting

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PODER Familiar: Health Promotion for Latino Families of Children With IDD

for Health-Related Behavior

2 locations incl. Chicago

Sponsor: University of Texas at Austin

Sex: All·Age: 6 - 100·Accepts healthy volunteers

Code: NCT05713617·Recruiting

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Basic Experimental Study of Hippocampal Memory Functions

for Memory

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05945628·Enrolling By Invitation

Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis

for Multiple Sclerosis

12 locations incl. New Haven

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55

Code: NCT05285891·Phase 4·Recruiting

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FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3

for Urinary Bladder Neoplasms

41 locations incl. Tucson

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT05614739·Phase 1·Recruiting

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Alleviant ALLAY-HF Study

for Heart Failure

53 locations incl. Birmingham

Sponsor: Alleviant Medical, Inc.

Sex: All·Age: 40+

Code: NCT05685303·Enrolling By Invitation

Evaluation of a Smartphone-based Screening Tool (Picterus JP) for Neonatal Jaundice (Chicago)

for Neonatal Jaundice

1 location in Chicago

Sponsor: Picterus AS

Sex: All·Age: 1 Day - 14 Days·Accepts healthy volunteers

Code: NCT05521607·Recruiting

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Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare

for Acute Gout Flare

25 locations incl. Birmingham

Sponsor: Olatec Therapeutics LLC

Sex: All·Age: 18+

Code: NCT05658575·Phase 2, Phase 3·Recruiting

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Post-Autologous Transplant Maintenance With Isatuximab and Lenalidomide in Minimal Residual Disease Positive Multiple Myeloma

for Multiple Myeloma

2 locations incl. Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT05344833·Phase 2·Recruiting

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Endurant Stent Graft System vs Excluder Endoprothesis: ADVANCE Trial

for Abdominal Aortic Aneurysm

32 locations incl. Loma Linda

Sponsor: Medtronic Cardiovascular

Sex: All·Age: 20+

Code: NCT05378347·Recruiting

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AFFINITY DUCHENNE: RGX-202 Gene Therapy in Participants With Duchenne Muscular Dystrophy (DMD)

for Duchenne Muscular Dystrophy

13 locations incl. Little Rock

Sponsor: REGENXBIO Inc.

Sex: Male·Age: 1+

Code: NCT05693142·Phase 2, Phase 3·Recruiting

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A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease

for Autoimmune Diseases

12 locations incl. Orange

Sponsor: TScan Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06587828·Recruiting

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At-home Walking Cadence Functional Assessment and Recovery Trajectory for Older Adults Undergoing Major Surgery

for Gait, Unsteady

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 60+

Code: NCT05886725·Recruiting

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International Rare Brain Tumor Registry

for Astroblastoma

6 locations incl. Los Angeles

Sponsor: Children's National Research Institute

Sex: All·Age: Up to 45

Code: NCT05697874·Recruiting

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Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

for Schizophrenia Spectrum and Other Psychotic Disorders

6 locations incl. Hartford

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 40

Code: NCT06740383·Recruiting

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JUPITER 4.0 - Risk Factors for Failure of Isolated Medial Patellofemoral Ligament Reconstruction

for Patellar Dislocation, Recurrent

16 locations incl. Redwood City

Sponsor: Hospital for Special Surgery, New York

Sex: All·Age: 10 - 35

Code: NCT06883396·Recruiting

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