SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer

Part of paid clinical trials in Corona, California.

Sponsor
Canadian Cancer Trials Group
Study ID
NCT05451004
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Lymphatic Mapping with SPECT-CT — OTHER
    Radiation: Ipsilateral Neck Radiotherapy and SPECT-CT Guided Contralateral Neck Radiotherapy
  • Ipsilateral and Contralateral Neck — RADIATION
    Radiotherapy

Study Details

This study is being done to answer the following question: Is the chance of cancer spreading or returning the same if radiotherapy to the neck is guided, by using a special imaging study called lymph node mapping (lymphatic mapping) Single Photon Emission Computed Tomography (SPECT-CT), compared to the usual treatment when radiotherapy is given to both sides of the neck?

Key Dates

Start date
Feb 10, 2023
Status verified
Jun 2026
Primary completion
Aug 30, 2030
Completion
Aug 30, 2031

Study Design

Enrollment
510 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Lympathic Mapping with SPECT-CT guided Radiotherapy
  • Active Comparator: Bilateral Neck Radiotherapy

Primary Outcome Measure

Disease-free Survival [ Time Frame: 8 years ]

Central Contacts

Locations (26)

FacilityCityStateZIPSite coordinators
City of Hope CoronaCoronaCalifornia92882
Site Public Contact
[email protected]
626-256-4673
Krupal B. Patel (PRINCIPAL_INVESTIGATOR)
City of Hope Comprehensive Cancer CenterDuarteCalifornia91010
Site Public Contact
[email protected]
800-826-4673
Krupal B. Patel (PRINCIPAL_INVESTIGATOR)
City of Hope at Irvine LennarIrvineCalifornia92618-
UM Sylvester Comprehensive Cancer Center at Coral GablesCoral GablesFlorida33146
Site Public Contact
305-243-2647
Gregory J. Kubicek (PRINCIPAL_INVESTIGATOR)
Baptist MD Anderson Cancer CenterJacksonvilleFlorida32207-
University of Miami Miller School of Medicine-Sylvester Cancer CenterMiamiFlorida33136
Site Public Contact
305-243-2647
Gregory J. Kubicek (PRINCIPAL_INVESTIGATOR)
Moffitt Cancer CenterTampaFlorida33612
Site Public Contact
[email protected]
800-679-0775
Deepa Danan (PRINCIPAL_INVESTIGATOR)
Moffitt Cancer Center - McKinley CampusTampaFlorida33612
Site Public Contact
[email protected]
800-679-0775
Deepa Danan (PRINCIPAL_INVESTIGATOR)
Moffitt Cancer Center-International PlazaTampaFlorida33607
Site Public Contact
[email protected]
800-679-0775
Deepa Danan (PRINCIPAL_INVESTIGATOR)
Emory University Hospital MidtownAtlantaGeorgia30308
Site Public Contact
888-946-7447
James E. Bates (PRINCIPAL_INVESTIGATOR)
Northwestern UniversityChicagoIllinois60611-
Northwestern Medicine Cancer Center WarrenvilleWarrenvilleIllinois60555-
The James Graham Brown Cancer Center at University of LouisvilleLouisvilleKentucky40202-
University of Michigan Rogel Cancer CenterAnn ArborMichigan48109
Site Public Contact
[email protected]
800-865-1125
David W. Forner (PRINCIPAL_INVESTIGATOR)
University of Michigan - Brighton Center for Specialty CareBrightonMichigan48116
Site Public Contact
800-865-1125
David W. Forner (PRINCIPAL_INVESTIGATOR)
Henry Ford HospitalDetroitMichigan48202
Site Public Contact
[email protected]
313-916-3721
Samantha H. Tam (PRINCIPAL_INVESTIGATOR)
MU Health - University Hospital/Ellis Fischel Cancer CenterColumbiaMissouri65212
Site Public Contact
573-882-7440
Patrick Tassone (PRINCIPAL_INVESTIGATOR)
UNC Lineberger Comprehensive Cancer CenterChapel HillNorth Carolina27599
Site Public Contact
[email protected]
877-668-0683
Colette Shen (PRINCIPAL_INVESTIGATOR)
Providence Portland Medical CenterPortlandOregon97213
Site Public Contact
[email protected]
503-215-2614
Charles W. Drescher (PRINCIPAL_INVESTIGATOR)
MD Anderson in The WoodlandsConroeTexas77384
Site Public Contact
[email protected]
866-632-6789
Anna Lee (PRINCIPAL_INVESTIGATOR)
M D Anderson Cancer CenterHoustonTexas77030
Site Public Contact
[email protected]
877-632-6789
Anna Lee (PRINCIPAL_INVESTIGATOR)
MD Anderson West HoustonHoustonTexas77079
Site Public Contact
[email protected]
877-632-6789
Anna Lee (PRINCIPAL_INVESTIGATOR)
MD Anderson League CityLeague CityTexas77573
Site Public Contact
[email protected]
877-632-6789
Anna Lee (PRINCIPAL_INVESTIGATOR)
MD Anderson in Sugar LandSugar LandTexas77478
Site Public Contact
[email protected]
877-632-6789
Anna Lee (PRINCIPAL_INVESTIGATOR)
University of Vermont and State Agricultural CollegeBurlingtonVermont05405
Site Public Contact
[email protected]
802-656-8990
Havaleh Gagne (PRINCIPAL_INVESTIGATOR)
University of Vermont Medical CenterBurlingtonVermont05401
Site Public Contact
[email protected]
802-656-4101
Havaleh Gagne (PRINCIPAL_INVESTIGATOR)

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