Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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A Pilot Phase II Study of Maintenance Cabozantinib Plus Pembrolizumab for Patients With Metastatic Squamous Non-Small Cell Lung Cancer (sqNSCLC)

for Metastatic Squamous Non-Small Cell Lung Carcinoma

Drug: Cabozantinib

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT05613413·Phase 2·Recruiting

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Study to Evaluate the Pharmacokinetics and Safety of Pralatrexate in Patients With Advanced Solid Tumor or Hematological Malignancy and Either Normal Hepatic Function or Mild, Moderate, or Severe Hepatic Impairment

for Advanced Solid Tumors

4 locations incl. Cerritos

Sponsor: Acrotech Biopharma Inc.

Sex: All·Age: 18+

Code: NCT07036133·Phase 1·Recruiting

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Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)

for Atrial Fibrillation (AF)

Drug: Abelacimab

150 locations incl. Birmingham

Sponsor: Anthos Therapeutics, Inc.

Sex: All·Age: 65+

Code: NCT05712200·Phase 3·Recruiting

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Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

for Cervical Cancer

8 locations incl. Chicago

Sponsor: Orano Med Theranostics, SAS

Sex: All·Age: 18+

Code: NCT05283330·Phase 1·Recruiting

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PROMISE III: Percutaneous Deep Vein Arterialization for the Treatment of Late-Stage Chronic Limb-Threatening Ischemia

for Critical Limb Ischemia

30 locations incl. La Jolla

Sponsor: LimFlow, Inc.

Sex: All·Age: 18 - 95

Code: NCT05313165·Recruiting

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A Clinical Trial of PR001 (LY3884961) in Patients With Peripheral Manifestations of Gaucher Disease (PROCEED)

for Gaucher Disease

4 locations incl. Los Angeles

Sponsor: Prevail Therapeutics

Sex: All·Age: 18+

Code: NCT05487599·Phase 1, Phase 2·Recruiting

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Adjuvant Therapy in POLE-Mutated and p53-Wildtype/NSMP Early Stage Endometrial Cancer RAINBO BLUE & TAPER

for Endometrial Cancer

68 locations incl. Anchorage

Sponsor: Canadian Cancer Trials Group

Sex: Female·Age: 18+

Code: NCT05640999·Phase 2·Recruiting

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A Study to Evaluate Etrasimod Treatment in Adolescents With Ulcerative Colitis

for Ulcerative Colitis

20 locations incl. Little Rock

Sponsor: Pfizer

Sex: All·Age: 12 - 17

Code: NCT05287126·Phase 2·Recruiting

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Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer

for Lung Adenocarcinoma

34 locations incl. Buena Park

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05198830·Phase 2·Recruiting

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Study of CHS-114 in Participants With Advanced Solid Tumors

for Advanced Solid Tumor

16 locations incl. Newport Beach

Sponsor: Coherus Oncology, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05635643·Phase 1·Recruiting

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Effectiveness of Relationship Education for Reducing HIV Incidence Among Men Who Have Sex With Men

for Hiv

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 16 - 34·Accepts healthy volunteers

Code: NCT05678556·Recruiting

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Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients

for Hematopoietic Cell Transplant

27 locations incl. Birmingham

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: Up to 18

Code: NCT05550298·Recruiting

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Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

for Viral Lung Infection and Acute Respiratory Failure

68 locations incl. Mobile

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05624450·Phase 3·Recruiting

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Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

for Triple Negative Breast Cancer

184 locations incl. Birmingham

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT05633654·Phase 3·Recruiting

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Home-based FES Training in People With Chronic Stroke

for Chronic Stroke

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 90

Code: NCT05849532·Recruiting

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Impact of Sentinel Lymph Node Mapping on Patient Reported Lower Extremity Limb Dysfunction in Stage I Endometrial Cancer

for Stage I Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8

55 locations incl. Washington D.C.

Sponsor: NRG Oncology

Sex: Female·Age: 18+

Code: NCT05646316·Phase 3·Recruiting

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BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

for Clinical Stage III Cutaneous Melanoma AJCC v8

Drug: Cabozantinib

222 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05136196·Phase 2·Recruiting

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Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer

for Colorectal Cancer

2 locations incl. Denver

Sponsor: San Raffaele University

Sex: All·Age: 18 - 49·Accepts healthy volunteers

Code: NCT05732623·Recruiting

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His-Bundle Corrective Pacing in Heart Failure

for Right Bundle-Branch Block

14 locations incl. Phoenix

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05265520·Recruiting

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My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Life

for Cancer

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05369429·Recruiting

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Evaluating Personalized Therapeutics Clinic (PTC) on Drug-Drug Interactions and Drug-Gene Interactions

for Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05166694·Recruiting

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Therasphere® and Systemic Therapy for Patients With Hepatocellular Carcinoma That is High-risk

for Hepatocellular Carcinoma

7 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT05620771·Phase 2·Recruiting

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An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

for Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

46 locations incl. Scottsdale

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05667493·Phase 3·Enrolling By Invitation

Continuation of the nuMoM2b Heart Health Study

for Cardiovascular Diseases

14 locations incl. Orange

Sponsor: RTI International

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT05472597·Enrolling By Invitation

Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis

for Chronic Rhinitis

1 location in Evanston

Sponsor: Endeavor Health

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05626621·Phase 4·Recruiting

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Combination Therapies With Adagrasib in Patients With Advanced NSCLC With KRAS G12C Mutation

for Advanced NSCLC

Drug: Adagrasib

84 locations incl. Anchorage

Sponsor: Mirati Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT05609578·Phase 2·Recruiting

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Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

for Endometrial Carcinoma

403 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT05256225·Phase 3·Recruiting

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A Substudy of Investigational Agents in Programmed Cell Death-1/Ligand 1 (PD-1/L1) Refractory Locally Advanced or Metastatic Urothelial Carcinoma (mUC) (MK-3475-04A)

for Urothelial Carcinoma

10 locations incl. Orange

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT05562830·Phase 1, Phase 2·Recruiting

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DREAM: Double Lung Transplant REgistry Aimed for Lung-limited Malignancies

for Lung Cancer

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 75

Code: NCT05671887·Recruiting

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Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

for Advanced Malignant Solid Neoplasm

36 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05327010·Phase 2·Recruiting

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Suture Repair vs Mesh Repair for Incisional Hernia

for Incisional Hernia

5 locations incl. Gainesville

Sponsor: Clayton Petro

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05599750·Recruiting

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EXCOR Active Driving System for the EXCOR Pediatric VAD IDE Study

for Heart Failure

15 locations incl. Los Angeles

Sponsor: Berlin Heart, Inc

Sex: All·Age: Up to 21

Code: NCT05610787·Enrolling By Invitation

Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

for Hematologic Malignancy

29 locations incl. Los Angeles

Sponsor: Therapeutic Advances in Childhood Leukemia Consortium

Sex: All·Age: 1 - 21

Code: NCT05476770·Phase 1·Recruiting

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Furthering Equity Through Infant Feeding EDucation and Support

for Breastfeeding

4 locations incl. Chicago

Sponsor: Endeavor Health

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05441709·Recruiting

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Levonorgestrel 52 mg IUD for Emergency Contraception and Same-Day Start

for Contraception

8 locations incl. San Jose

Sponsor: University of Utah

Sex: Female·Age: 16 - 35

Code: NCT05444582·Phase 4·Recruiting

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The Diabetes Prevention Program Outcomes Study AD/ADRD Project

for Diabetes

27 locations incl. Phoenix

Sponsor: Marinella Temprosa

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05704309·Enrolling By Invitation

Testing the Combination of Nivolumab and ASTX727 for Relapsed or Refractory B-Cell Lymphoma

for Recurrent B-Cell Non-Hodgkin Lymphoma

Drug: Nivolumab

9 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05272384·Phase 1·Recruiting

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Improving Adherence to Spinal Cord Injury Exercise Guidelines Using Smartphone Technology and E-coaching

for Spinal Cord Injuries

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 80

Code: NCT05424172·Recruiting

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Every Day Counts: A Lifestyle Program for Women With Metastatic Breast Cancer

for Metastatic Breast Cancer

2 locations incl. Maywood

Sponsor: Medical College of Wisconsin

Sex: Female·Age: 18+

Code: NCT03824145·Recruiting

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Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

for Premature Birth

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 30 Weeks - 83 Months

Code: NCT05336890·Recruiting

Apply to this trial