Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Study ID
NCT05336890
Status
Recruiting
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Conditions

  • Asthma in Children
  • Neurodevelopmental Disorders
  • Premature Birth
  • Sleep-Disordered Breathing

Eligibility Criteria

Sex
ALL
Age
30 Weeks - 83 Months
Healthy Volunteers
Not accepted

Study Details

Despite improved survival of extremely premature infants in recent decades, neonatal intensive care unit (NICU) graduates are diagnosed with asthma, sleep disordered breathing (SDB) in childhood, and neurodevelopmental impairments (NDI) at significant rates, disproportionate to their term peers. Early detection and intervention are critical to mitigate the impact of these impairments. Mechanisms leading from premature birth to these undesirable outcomes remain unclear, and accurate prognostic measures are lacking. This study wants to learn if these problems are related to certain patterns of breathing that babies had while they were in the NICU.

Key Dates

Start date
Nov 1, 2022
Status verified
Nov 2024
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
500 participants (estimated)

Primary Outcome Measure

Asthma [ Time Frame: 5 years ± 6 months of age ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Ann & Robert H. Lurie Children's Hospital of ChicagoChicagoIllinois60611
Erin Lonergan, RRT, MS
Casey Rand

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By research site
Ann & Robert H. Lurie Children's Hospital of Chicago· Chicago, IL

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