Paid Clinical Trials in Illinois

Illinois has 2,968 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age

for Amblyopia

58 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 8 - 12

Code: NCT06524882·Phase 3·Recruiting

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A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.

for Metastatic Castration-Resistant Prostate Cancer

Drug: Mevrometostat

44 locations incl. Chandler

Sponsor: Pfizer

Sex: Male·Age: 18+

Code: NCT06629779·Phase 3·Recruiting

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A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

for Carcinoma, Non-Small-Cell Lung

Drug: Intismeran autogene

48 locations incl. Gilbert

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06623422·Phase 3·Recruiting

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Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms of Long COVID

for Long COVID

Drug: Baricitinib

17 locations incl. Tucson

Sponsor: Wes Ely

Sex: All·Age: 18+

Code: NCT06631287·Phase 3·Recruiting

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Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL

for Hypertensive Disorders of Pregnancy

16 locations incl. Birmingham

Sponsor: Ohio State University

Sex: Female·Age: 14 - 35

Code: NCT06468202·Phase 4·Recruiting

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A Study to Assess the Efficacy and Safety of Efgartigimod IV in Adult Participants With Primary Immune Thrombocytopenia

for Primary Immune Thrombocytopenia (ITP)

18 locations incl. Phoenix

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT06544499·Phase 3·Recruiting

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Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy

for Diabetic Peripheral Neuropathic Pain

25 locations incl. Cullman

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 80

Code: NCT06619860·Phase 2·Recruiting

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A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

for Colorectal Neoplasms

Drug: Amivantamab

79 locations incl. Gilbert

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06662786·Phase 3·Recruiting

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Hospital Implementation of a Stroke Protocol for Emergency Evaluation and Disposition

for Stroke, Acute

8 locations incl. New Haven

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06094478·Recruiting

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J-Valve Transfemoral Pivotal Study

for Aortic Valve Regurgitation

34 locations incl. Scottsdale

Sponsor: JC Medical, Inc., an affiliate of Edwards Lifesciences LLC

Sex: All·Age: 18+

Code: NCT06455787·Recruiting

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Immune Status After Being on Call for 24 Hrs

for Sleep Deprivation

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06636318·Recruiting

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A Study to Evaluate Subcutaneous Zilucoplan in Pediatric Participants With Generalized Myasthenia Gravis

for Generalized Myasthenia Gravis

2 locations incl. Chicago

Sponsor: UCB Biopharma SRL

Sex: All·Age: 12 - 17

Code: NCT06055959·Phase 2, Phase 3·Recruiting

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Diabetes RElated to Acute Pancreatitis and Its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics

for Acute Pancreatitis

13 locations incl. Los Angeles

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 18 - 75

Code: NCT06401577·Recruiting

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A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study

for Hematopoietic and Lymphatic System Neoplasm

76 locations incl. Mesa

Sponsor: Children's Oncology Group

Sex: All·Age: 15 - 20

Code: NCT06410209·Phase 2·Recruiting

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Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response

for Arthritis, Psoriatic

44 locations incl. Avondale

Sponsor: MoonLake Immunotherapeutics AG

Sex: All·Age: 18+

Code: NCT06641089·Phase 3·Recruiting

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Comparing Telephone Symptom Monitoring Interventions for Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment

for Hematopoietic and Lymphatic System Neoplasm

30 locations incl. Phoenix

Sponsor: NRG Oncology

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06279013·Recruiting

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Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)

for Liver Neoplasms

30 locations incl. Fullerton

Sponsor: HistoSonics, Inc.

Sex: All·Age: 22+

Code: NCT06486454·Recruiting

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FK-PC101 as Adjuvant Therapy for Men With High-Risk Prostate Cancer

for Prostate Cancer (Adenocarcinoma)

3 locations incl. Chicago

Sponsor: Cellvax Therapeutics Inc

Sex: Male·Age: All ages

Code: NCT06636682·Phase 2·Recruiting

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A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia

for Leukemia, Juvenile Myelomonocytic

Drug: Trametinib

19 locations incl. Phoenix

Sponsor: Therapeutic Advances in Childhood Leukemia Consortium

Sex: All·Age: 1 Month - 21

Code: NCT05849662·Phase 1, Phase 2·Recruiting

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Beamion PANTUMOR-1: A Study to Test Whether Zongertinib Helps People With Advanced Cancers With HER2 Alterations

for Solid Tumours

20 locations incl. Anchorage

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06581432·Phase 2·Recruiting

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QuantifyHER: Quantitative Immunofluorescence and/or RT-qPCR for Measuring HER2 in HER2-low Metastatic Breast Cancer

for HER2-positive Metastatic Breast Cancer

37 locations incl. San Francisco

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06551116·Recruiting

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A Study of Eltrekibart and Mirikizumab in Adult Patients With Moderately to Severely Active Ulcerative Colitis

for Ulcerative Colitis

46 locations incl. Chandler

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT06598943·Phase 2·Recruiting

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A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis

for Diffuse Cutaneous Systemic Sclerosis

Drug: Ianalumab

17 locations incl. Mesa

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 70

Code: NCT06470048·Phase 2·Recruiting

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Gluten Technology and Education for Celiac Health

for Celiac Disease

4 locations incl. Chicago

Sponsor: Columbia University

Sex: All·Age: 18 - 75

Code: NCT06059716·Recruiting

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Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR

for Tachycardia Atrial

1 location in Oak Lawn

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06376916·Phase 3·Recruiting

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A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%

for Non-small Cell Lung Cancer

Drug: Relatlimab

45 locations incl. Mobile

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06561386·Phase 3·Recruiting

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Subcutaneous Tarlatamab in Participants With Extensive Stage Small Cell Lung Cancer (DeLLphi-308)

for Extensive Stage Small Cell Lung Cancer

Drug: Tarlatamab

6 locations incl. Los Angeles

Sponsor: Amgen

Sex: All·Age: 18+

Code: NCT06598306·Phase 1·Recruiting

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iCardia4HF: Multi-component mHealth Intervention for Patients With Heart Failure

for Heart Failure

2 locations incl. Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT06205225·Recruiting

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A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer

for Metastatic Non-small Cell Lung Cancer

Drug: Osimertinib

34 locations incl. Fayetteville

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06417814·Phase 3·Recruiting

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Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

for Acute Respiratory Distress Syndrome

14 locations incl. Los Angeles

Sponsor: BioAegis Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT05947955·Phase 2·Recruiting

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THRIVE- THerapeutic IntravasculaR Ultrasound (TIVUS™) REnal Denervation System Versus Sham for the Adjunctive Treatment of Hypertension

for Hypertension

33 locations incl. Birmingham

Sponsor: SoniVie Inc.

Sex: All·Age: 22 - 75

Code: NCT06559891·Recruiting

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A Study of BG-C477 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

9 locations incl. Goodyear

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06596473·Phase 1·Recruiting

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Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma

for Peripheral T-Cell Lymphoma, Not Otherwise Specified

Drug: Soquelitinib

21 locations incl. Duarte

Sponsor: Corvus Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06561048·Phase 3·Recruiting

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A Trial to Test if TEV-56286 is Effective for Treatment of Participants With Multiple System Atrophy

for Multiple System Atrophy

19 locations incl. La Jolla

Sponsor: Teva Branded Pharmaceutical Products R&D LLC

Sex: All·Age: 30 - 75

Code: NCT06568237·Phase 2·Recruiting

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Aspirin and Hemocompatibility Events in Chronic Advanced Heart Failure Patients With Assist Device

for Bleeding

3 locations incl. Chicago

Sponsor: Columbia University

Sex: All·Age: 18+

Code: NCT06655376·Phase 4·Recruiting

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Active Balance and Cardio Care Intervention on Physical and Cardiovascular Health in People With Chronic Stroke

for Chronic Stroke

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 45 - 90

Code: NCT06060470·Not Yet Recruiting

Infant Formula in Infants and Children With Cow's Milk Allergy

for Cow's Milk Allergy

9 locations incl. Phoenix

Sponsor: Abbott Nutrition

Sex: All·Age: 3 Months - 12

Code: NCT06456541·Recruiting

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Trial of Nadofaragene Firadenovec vs. Observation in Participants With Intermediate Risk Non-Muscle Invasive Bladder Cancer

for Intermediate Risk Non-Muscle Invasive Bladder Cancer

Drug: Nadofaragene Firadenovec

50 locations incl. Mobile

Sponsor: Ferring Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06510374·Phase 3·Recruiting

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A Trial to Evaluate Intravesical Nadofaragene Firadenovec Alone or in Combination With Chemotherapy or Immunotherapy in Participants With High-grade BCG Unresponsive Non-muscle Invasive Bladder Cancer

for Non-muscle Invasive Bladder Cancer With Carcinoma in Situ

Drug: Nadofaragene Firadenovec

38 locations incl. Tucson

Sponsor: Ferring Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06545955·Phase 3·Recruiting

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Testing a Real-time Electronic Antiretroviral Adherence Monitoring Intervention

for HIV Infections

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06550804·Phase 3·Recruiting

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