Diabetes RElated to Acute Pancreatitis and Its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics

Part of paid clinical trials in Los Angeles, California.

Sponsor
Milton S. Hershey Medical Center
Study ID
NCT06401577
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Dexcom Continuous Glucose Monitor (CGM) — DEVICE
    Dexcom Continuous Glucose Monitor which measures and records a participant's serum glucose level

Study Details

The DREAM-ON study will investigate whether continuous glucose monitoring (CGM) is useful to predict risk for developing diabetes mellitus (DM) and pre-diabetes mellitus (PDM), the need for insulin therapy among those who develop DM, and to determine whether CGM can provide insight into the pathophysiology and DM subtype among participants who have experienced an episode of acute pancreatitis (AP). Thus, the results of the DREAM-ON study could inform future clinical practice guidelines for the management AP as well as potentially extending the licensing authorization for CGM to include use in patients with pancreatogenic (Type 3c) DM.

Key Dates

Start date
Oct 16, 2024
Status verified
Feb 2026
Primary completion
Dec 31, 2026
Completion
Mar 31, 2027

Study Design

Enrollment
800 participants (estimated)

Arms

  • Arm: CGM
    Continuous Glucose Monitoring (CGM)

Primary Outcome Measure

pre-diabetes mellitus following an episode of acute pancreatitis [ Time Frame: any time during the 36-month longitudinal follow-up period ]

Central Contacts

Locations (13)

FacilityCityStateZIPSite coordinators
Cedars-Sinai Medical CenterLos AngelesCalifornia90048
Eleanor Chang
[email protected]
310-423-0747
Mark O Goodarzi, MD, PhD (PRINCIPAL_INVESTIGATOR)
Stephen J Pandol, MD (PRINCIPAL_INVESTIGATOR)
University of Southern CaliforniaLos AngelesCalifornia90033
Jessica Serna
[email protected]
323-409-6939
James L Buxbaum, MD (PRINCIPAL_INVESTIGATOR)
Stanford UniversityStanfordCalifornia94305
Lorena Pineda
[email protected]
650-723-4519
Walter Park, MD (PRINCIPAL_INVESTIGATOR)
Marina Basina, MD (PRINCIPAL_INVESTIGATOR)
University of FloridaGainesvilleFlorida32610-0214
Amber Bouton
[email protected]
352-273-9774
Chris Forsmark, MD (PRINCIPAL_INVESTIGATOR)
Steven J Hughes, MD (PRINCIPAL_INVESTIGATOR)
AdventHealthOrlandoFlorida32804
Gina Mercouffer
[email protected]
407-303-7106
Richard E Pratley, MD (PRINCIPAL_INVESTIGATOR)
Northwestern UniversityChicagoIllinois60611
Christine Nelson
[email protected]
312-695-4513
Rajesh N Keswani, MD, MS (PRINCIPAL_INVESTIGATOR)
University of Illinois at ChicagoChicagoIllinois60612
Haya Al Rashdan
[email protected]
312-413-0306
Cemal Yazici, MD, MSc (PRINCIPAL_INVESTIGATOR)
Brian Layden, MD (PRINCIPAL_INVESTIGATOR)
Indiana UniversityIndianapolisIndiana46202
Maureen Mullen-Montagano
[email protected]
317-274-7677
Evan L Fogel, MD (PRINCIPAL_INVESTIGATOR)
Carmella Evans-Molina, MD, PhD (PRINCIPAL_INVESTIGATOR)
Johns Hopkins UniversityBaltimoreMaryland21205
Mahya Faghih
[email protected]
443-287-4680
Vikesh Singh, MD, MSc (PRINCIPAL_INVESTIGATOR)
Zhaoli Sun, MD, PhD (PRINCIPAL_INVESTIGATOR)
University of MinnesotaMinneapolisMinnesota55454
Heather Hodgkins
[email protected]
612-626-5293
Melena D Bellin, MD (PRINCIPAL_INVESTIGATOR)
Guru Trikudanathan, MD (PRINCIPAL_INVESTIGATOR)
Ohio State UniversityColumbusOhio43210
Zoe Krebs
[email protected]
614-685-6374
Phillip A Hart, MD (PRINCIPAL_INVESTIGATOR)
Georgios Papachristou, MD, PhD (PRINCIPAL_INVESTIGATOR)
University of PittsburghPittsburghPennsylvania15213
Shari Reynolds
[email protected]
412-383-0570
Dhiraj Yadav, MD, MPH (PRINCIPAL_INVESTIGATOR)
Frederico GS Toledo, MD (PRINCIPAL_INVESTIGATOR)
Benaroya Research InstituteSeattleWashington98101
Kim Varner
[email protected]
206-341-8936
Carla J Greenbaum, MD (PRINCIPAL_INVESTIGATOR)
Richard A Kozarek, MD (PRINCIPAL_INVESTIGATOR)

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