A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.

Part of paid clinical trials in Chandler, Arizona.

Sponsor
Pfizer
Study ID
NCT06629779
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
MALE
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • PF-06821497 — DRUG
    Oral continuous
  • Placebo — DRUG
    Oral continuous
  • Enzalutamide — DRUG
    Oral continuous

Study Details

This study will explore whether a combination of the investigational drug PF-06821497 and enzalutamide will work better than taking enzalutamide alone in participants with mCRPC who are ARSi or abiraterone naïve.

Key Dates

Start date
Oct 22, 2024
Status verified
Jun 2026
Primary completion
Dec 2, 2026
Completion
Nov 30, 2028

Study Design

Enrollment
900 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Arm A
    Participants will receive PF-06821497 (875 mg) BID (twice daily) + enzalutamide 160 mg QD (once daily)
  • Active Comparator: Arm B
    Participants will receive Placebo BID (twice daily) + enzalutamide 160 mg QD (once daily)

Primary Outcome Measure

Radiographic Progression Free Survival (rPFS) [ Time Frame: Randomization up to approximately 3 years ]

Central Contacts

Locations (44)

FacilityCityStateZIPSite coordinators
Ironwood Cancer & Research CentersChandlerArizona85224-
Ironwood Cancer & Research CentersGilbertArizona85297-
Ironwood Cancer & Research CentersGlendaleArizona85306-
Palo Verde Hematology OncologyGlendaleArizona85304-
Ironwood Cancer & Research CentersGoodyearArizona85395-
Ironwood Cancer & Research CentersMesaArizona85202-
Ironwood Cancer & Research CentersMesaArizona85206-
Ironwood Cancer & Research CentersPhoenixArizona85028-
Ironwood Cancer & Research CentersScottsdaleArizona85260-
Highlands OncologyFayettevilleArkansas72703-
Arkansas Urology - Little RockLittle RockArkansas72211-
Highlands OncologyRogersArkansas72758-
Highlands Oncology GroupSpringdaleArkansas72762-
Los Angeles Cancer Network (LACN)AnaheimCalifornia92805-
Los Angeles Cancer Network (LACN)Fountain ValleyCalifornia92708-
Los Angeles Cancer Network (LACN)GlendaleCalifornia91204-
Los Angeles Cancer Network (LACN)GlendaleCalifornia91206-
Los Angeles Cancer Network (LACN)Laguna HillsCalifornia92653-
Los Angeles Cancer Network (LACN)Los AngelesCalifornia90017-
Los Angeles Cancer Network (LACN)Los AngelesCalifornia90067-
Medical Oncology Associates of San DiegoSan DiegoCalifornia92123-
Accellacare of DulyLisleIllinois60532-
Duly Health and Care (Bone Scintigraphy)LisleIllinois60532-
Blessing HospitalQuincyIllinois62301-
Blessing Physician ServicesQuincyIllinois62301-
Duly Health and Care (CT and MRI)WestmontIllinois60559-
Adult & Pediatric Urology, PCOmahaNebraska68114-
CHRISTUS St. Vincent Regional Cancer CenterSanta FeNew Mexico87505-
Montefiore Medical CenterThe BronxNew York10467-
Montefiore Medical Center - Medical ParkThe BronxNew York10461-
Salisbury VA Medical CenterSalisburyNorth Carolina28144-
AUC Urologists, LLCMyrtle BeachSouth Carolina29572-
Carolina Urologic Research Center, LLCMyrtle BeachSouth Carolina29572-
Grand Strand Medical CenterMyrtle BeachSouth Carolina29572-
Parkway Surgery CenterMyrtle BeachSouth Carolina29572-
USA Clinical TrialsSan AntonioTexas78229-
Northwest Medical Specialties, PLLCBonney LakeWashington98391-
Northwest Medical Specialties, PLLCFederal WayWashington98003-
Northwest Medical Specialties, PLLCGig HarborWashington98332-
Northwest Medical Specialties, PLLCPuyallupWashington98373-
Fred Hutchinson Cancer CenterSeattleWashington98109-
Harborview Medical CenterSeattleWashington98104-
University of Washington Medical Center - MontlakeSeattleWashington98195-
Northwest Medical Specialties, PLLCTacomaWashington98405-

Find similar trials in Chandler, AZ

By condition
Prostate cancer
By specialty
OncologyProstate oncologyMen's healthUrology
By research site
Ironwood Cancer & Research Centers· Chandler, AZIronwood Cancer & Research Centers· Gilbert, AZIronwood Cancer & Research Centers· Glendale, AZPalo Verde Hematology Oncology· Glendale, AZIronwood Cancer & Research Centers· Goodyear, AZIronwood Cancer & Research Centers· Mesa, AZ

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