Paid Clinical Trials in Illinois

Illinois has 2,953 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,953 clinical trials

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Registry on NeVa VS for CerebraL VAsospasm ManagemenT in Post SAH PatiEnts

for Cerebral Vasospasm

16 locations incl. Burbank

Sponsor: Vesalio

Sex: All·Age: 22+

Code: NCT06893588·Recruiting

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Optimizing Mango's Glycemic Impact: Investigating Mango Consumption Timing in Prediabetic Individuals

for Pre Diabetes

1 location in Chicago

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Sex: All·Age: 20 - 60·Accepts healthy volunteers

Code: NCT06986161·Recruiting

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Study of Targeted Therapies for the Treatment of Adult Participants With Active Psoriatic Arthritis

for Psoriatic Arthritis

16 locations incl. Huntington Beach

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06865105·Phase 2·Recruiting

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A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

for Lymphoma, Large B-Cell, Diffuse

Drug: Polatuzumab Vedotin

70 locations incl. Mobile

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06890884·Phase 2·Recruiting

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Evaluating Pumpkin Seed Oil Extract Supplementation on Bladder Function

for Overactive Bladder (OAB)

1 location in Chicago

Sponsor: Northwestern University

Sex: Female·Age: 18+

Code: NCT06944392·Recruiting

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Mechanisms of SGLT2 Inhibition in Pediatric Steatotic Liver Disease

for Non-Alcoholic Fatty Liver Disease

1 location in Chicago

Sponsor: Justin Ryder

Sex: All·Age: 16 - 20

Code: NCT06355310·Phase 2·Recruiting

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Targeted Investigation of Microbiome 2 Treat Atopic Dermatitis (TIME-2)

for Atopic Dermatitis

8 locations incl. San Diego

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 6+

Code: NCT06504160·Phase 1·Recruiting

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

for Carcinoma, Non-Small Cell Lung

Drug: Rilvegostomig

37 locations incl. La Mesa

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06868277·Phase 3·Recruiting

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An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut Syndrome

for Lennox Gastaut Syndrome

20 locations incl. Little Rock

Sponsor: Epygenix

Sex: All·Age: 2 - 55

Code: NCT05066217·Phase 3·Recruiting

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Tissue Reinforcement for Breast Reconstruction (TRBR) Pivotal Clinical Study (REDEFINE)

for Breast Reconstruction Surgery

20 locations incl. Scottsdale

Sponsor: W.L.Gore & Associates

Sex: Female·Age: 22+

Code: NCT06556654·Recruiting

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A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

for Breast Cancer

51 locations incl. Phoenix

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06790693·Phase 3·Recruiting

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Long-Term Safety and Efficacy of Plozasiran in Adults With Hypertriglyceridemia

for Hypertriglyceridemia

Drug: Plozasiran

76 locations incl. Bakersfield

Sponsor: Arrowhead Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06822790·Phase 3·Recruiting

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Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

for Extensive Stage Lung Small Cell Carcinoma

Drug: Atezolizumab

43 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06287775·Phase 1, Phase 2·Recruiting

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Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis

for Multiple Sclerosis, Relapsing-Remitting

12 locations incl. Loma Linda

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 10 - 17

Code: NCT06408259·Phase 3·Recruiting

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CardiolRx in Recurrent Pericarditis (MAVERIC Phase-3)

for Recurrent Pericarditis

21 locations incl. Phoenix

Sponsor: Cardiol Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06708299·Phase 3·Recruiting

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NSAID Use for Treating Dysmenorrhea and Preventing Chronic Pelvic Pain (NSAID HEAL)

for Dysmenorrhea

1 location in Evanston

Sponsor: Endeavor Health

Sex: Female·Age: 18 - 35

Code: NCT06861920·Phase 4·Recruiting

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Patiromer for Treatment of Hyperkalaemia in Children Under 12 Years of Age

for Hyperkalemia

Drug: patiromer

13 locations incl. Aurora

Sponsor: Vifor Pharma, Inc.

Sex: All·Age: 0 - 11

Code: NCT05766839·Phase 2·Recruiting

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Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer

for Extensive Stage Small Cell Lung Cancer (ES-SCLC)

19 locations incl. Hot Springs

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06801834·Phase 3·Recruiting

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Exploring the Relationship Between Heart Rate Variability (HRV), Training Load, and Endurance Performance

for Heart Rate Variability

1 location in Chicago

Sponsor: PepsiCo Global R&D

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06964100·Recruiting

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Tapinarof for Cutaneous Lupus Erythematosus

for Cutaneous Lupus Erythematosus

Drug: Tapinarof

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06661213·EARLY_Phase 1·Enrolling By Invitation

Micromanaging Human Sleep Physiology to Treat Sleep Apnea and Other Disorders

for Sleep Apnea Obstructive (OSA)

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 60

Code: NCT06926036·Recruiting

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A Study to Compare the Efficacy and Safety of TachoSil and Surgicel Original as an Adjunct to Control Mild to Moderate Soft Tissue Bleeding During Surgery

for Hemorrhage

9 locations incl. Torrance

Sponsor: Corza Medical GmbH

Sex: All·Age: 1 Month+

Code: NCT06664775·Phase 3·Recruiting

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A Digital Therapeutic Platform for Swallowing and Drooling Problems in Parkinson's

for Dysphagia

1 location in Evanston

Sponsor: Northwestern University

Sex: All·Age: 22+

Code: NCT04664634·Phase 3·Recruiting

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Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

for Lung Non-Small Cell Carcinoma

243 locations incl. Jonesboro

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06498635·Phase 3·Recruiting

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Does Ethyl Chloride Spray Work?

for Injection Fear

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06651788·Recruiting

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Pain After Strabismus Surgery

for Strabismus

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 4 - 12

Code: NCT06689943·Phase 2·Not Yet Recruiting

MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas

for Low Grade Glioma

3 locations incl. Washington D.C.

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 1 - 26

Code: NCT06712875·Phase 1, Phase 2·Recruiting

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Preventative Screening and Health Coaching in a Food Insecure Population

for Cardiovascular Disease Prevention

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 40 - 75

Code: NCT06907524·Not Yet Recruiting

The Dragon PLC Trial (DRAGON-PLC)

for Primary Liver Cancer

5 locations incl. New Haven

Sponsor: Maastricht University

Sex: All·Age: 18+

Code: NCT06914648·Recruiting

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Perioperative Anticoagulant Use for Surgery Evaluation -2 (PAUSE-2) Study Patients Receiving a Direct Oral Anticoagulant (DOACs-Dabigatran, Rivaroxaban, Apixaban or Edoxaban) and Needing Elective High-Bleed-Risk Surgery or an Invasive Procedure

for Atrial Fibrillation (AF)

6 locations incl. Hartford

Sponsor: McMaster University

Sex: All·Age: 18+

Code: NCT06957366·Recruiting

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Study of Olutasidenib and Temozolomide in HGG

for High Grade Glioma

10 locations incl. Aurora

Sponsor: Rigel Pharmaceuticals

Sex: All·Age: 12 - 39

Code: NCT06161974·Phase 2·Recruiting

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Prophylactic Conjoint Tendon Lengthening During Reverse Shoulder Arthroplasty Outcomes

for Osteoarthritis Shoulder

1 location in Maywood

Sponsor: Nickolas Garbis

Sex: All·Age: 18+

Code: NCT06729983·Recruiting

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CT-95 in Advanced Cancers Associated With Mesothelin Expression

for Mesothelin-Expressing Tumors

9 locations incl. Denver

Sponsor: Context Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06756035·Phase 1·Recruiting

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A Study of PHST001 in Advanced Solid Tumors

for Advanced Solid Tumors

20 locations incl. Beverly Hills

Sponsor: Pheast Therapeutics

Sex: All·Age: 18+

Code: NCT06840886·Phase 1·Recruiting

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A Study to Assess the Safety, Tolerability, and Efficacy of NDI-219216 in Patients With Advanced Solid Tumors.

for Advanced Solid Tumors Cancer

11 locations incl. Los Angeles

Sponsor: Nimbus Wadjet, Inc.

Sex: All·Age: 18 - 99

Code: NCT06898450·Phase 1, Phase 2·Recruiting

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BBO-11818 in Adult Subjects With KRAS Mutant Cancer

for Non-Small Cell Lung Cancer

16 locations incl. Los Angeles

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06917079·Phase 1·Recruiting

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A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Ulcerative Colitis

for Colitis Ulcerative

19 locations incl. Sun City

Sponsor: Sanofi

Sex: All·Age: 18 - 75

Code: NCT06867094·Phase 2·Recruiting

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The Pivotal Study of RapidPulseTM Aspiration System

for Acute Ischemic Stroke

18 locations incl. Torrance

Sponsor: RapidPulse, Inc

Sex: All·Age: 18 - 80

Code: NCT06029491·Recruiting

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A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting

for Ulcerative Colitis

100 locations incl. Birmingham

Sponsor: Takeda

Sex: All·Age: 18 - 80

Code: NCT06581328·Phase 4·Recruiting

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Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

for Metastatic Head and Neck Squamous Cell Carcinoma

177 locations incl. Little Rock

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06589804·Phase 3·Recruiting

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