Micromanaging Human Sleep Physiology to Treat Sleep Apnea and Other Disorders

Conditions

• Sleep Apnea Obstructive (OSA)

Eligibility Criteria

Sex

ALL

Age

18 Years - 60 Years

Healthy Volunteers

Not accepted

Interventions

• Wake training + TMR — BEHAVIORAL
  In this within-participant design, all participants will undergo the same intervention of waking training and TMR. Waking training - waking training will associate an auditory cue with a specific learned behavioral response (a tongue protrusion and inhalation) during daily sessions for approximately one week, with home sleep monitoring. TMR - Targeted memory reactivation (TMR) refers to the process of playing learning-associated audio cues quietly during sleep in order to reactivate memories associated with the cue. After completion of waking training, TMR occurs in a laboratory setting, with PSG recording, during a single night.

Study Details

This study will examine whether a combination of breathing training during wake and targeted reactivation of the training during sleep can induce breathing changes during sleep and subsequent cognitive benefits during wake. Participants with obstructive sleep apnea (who have not yet been treated for sleep apnea) will be recruited. Participants will engage in breath training for one week in their own homes and to record their sleep at home using commercially available mobile devices and subsequently have their sleep monitored for one night of polysomnography recordings plus targeted reactivation in a laboratory setting.

Key Dates

Start date

Apr 3, 2025

Status verified

May 2026

Primary completion

Apr 30, 2027

Completion

Apr 30, 2027

Study Design

Enrollment

18 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: All participants

Primary Outcome Measure

Apnea-Hypopnea Index (AHI) [ Time Frame: Day 1 ]

Central Contacts

• Ken A Paller, PhD
  847-467-3370
  [email protected]

Locations (1)

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