Paid Clinical Trials in Illinois

Illinois has 2,953 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,953 clinical trials

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Treatment of Moderate to Severe Refractory Crohn's Disease

for Crohns Disease

13 locations incl. Scottsdale

Sponsor: Tr1X, Inc.

Sex: All·Age: 18 - 65

Code: NCT06721962·Phase 1, Phase 2·Recruiting

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WISPer: Evaluation of MTX-463 in Participants With Idiopathic Pulmonary Fibrosis (IPF)

for Idiopathic Pulmonary Fibrosis

26 locations incl. Birmingham

Sponsor: Mediar Therapeutics

Sex: All·Age: 40+

Code: NCT06967805·Phase 2·Recruiting

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Assessment of CSF Shunt Flow and Headaches With a Thermal Measurement Device

for Hydrocephalus

1 location in Chicago

Sponsor: Rhaeos, Inc.

Sex: All·Age: 6 - 80

Code: NCT06996600·Recruiting

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A Phase 3 Study of 99mTC-EC-DG SPECT/CT Versus PET/CT in Lung Cancer

for Lung Cancer

1 location in Decatur

Sponsor: Cell>Point LLC

Sex: All·Age: 18+

Code: NCT01394679·Phase 3·Not Yet Recruiting

Physical Activity Targeting Metabolic Syndrome for Prevention of Breast Cancer in SAI Women

for Metabolic Syndrome

2 locations incl. Chicago

Sponsor: Rush University Medical Center

Sex: Female·Age: 40 - 65·Accepts healthy volunteers

Code: NCT06827704·Recruiting

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Genicular Artery Embolization for Reducing Pain in Medically Refractory Symptomatic Knee Osteoarthritis

for Knee Osteoarthritis

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 40 - 80

Code: NCT06859164·Phase 2·Recruiting

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Sickle Cell, Pain and Mediterranean Diet

for Sickle Cell

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT06886477·Recruiting

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Olfactory Cleft Obstruction and Electrophysiological Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients.

for Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP)

Drug: Dupilumab

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 65

Code: NCT06892704·Recruiting

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Motiva Implants® Post-Approval Study

for Breast Implant

30 locations incl. Beverly Hills

Sponsor: Motiva USA LLC

Sex: Female·Age: 22+·Accepts healthy volunteers

Code: NCT06938399·Recruiting

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Evaluation of Enhanced Lithotripsy System (ELS) in the Treatment of Urinary Stones, A Pivotal Trial

for Kidney Calculi

16 locations incl. Phoenix

Sponsor: Avvio Medical

Sex: All·Age: 21+

Code: NCT06942949·Recruiting

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Lp(a) Lowering Study of Pelacarsen (TQJ230) With Background Inclisiran in Participants With Elevated Lp(a) and Established ASCVD

for Atherosclerotic Cardiovascular Disease (ASCVD)

Drug: Inclisiran

37 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 80

Code: NCT06813911·Phase 3·Recruiting

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Conical Forearm and Cylindrical Upper Arm Non-Invasive Blood Pressure (NIBP) Measurements in Pregnant Patients

for Hypertension in Pregnancy

1 location in Chicago

Sponsor: Northwestern University

Sex: Female·Age: 18+

Code: NCT06466161·Recruiting

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A Study of HyQvia in Adults With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) in Routine Clinical Care

for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

9 locations incl. Rancho Mirage

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06538064·Recruiting

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Improving Safety, Patient Experience and Equity Through Shared Decision-making Huddles in Labor

for Perinatal Decision Making

1 location in Evanston

Sponsor: Endeavor Health

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06828406·Recruiting

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Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder

for Generalized Anxiety Disorder (GAD)

49 locations incl. Huntsville

Sponsor: AbbVie

Sex: All·Age: 18 - 65

Code: NCT06846320·Phase 2·Recruiting

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A Study Evaluating the Safety and Efficacy of Glofitamab + Gemcitabine + Oxaliplatin in U.S. Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

for Lymphoma

Drug: Glofitamab

16 locations incl. La Jolla

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06624085·Phase 1·Recruiting

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Preoperative Fasting vs. Not Fasting in Critically Ill Patients

for Critical Illness

19 locations incl. Palo Alto

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06751043·Recruiting

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Safely Optimizing Body Weight With TCMCB07 in Patients With Newly Diagnosed Colorectal Cancer Undergoing Chemotherapy

for Cancer Weight Loss

25 locations incl. Tucson

Sponsor: Endevica Bio

Sex: All·Age: 18+

Code: NCT06937177·Phase 2·Recruiting

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Mosaic Trial for Stem Cell Transplant Recipients

for Hematologic Malignancy

3 locations incl. Washington D.C.

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06960993·Recruiting

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Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults

for Electronic Nicotine Delivery Systems

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 26·Accepts healthy volunteers

Code: NCT06395415·Recruiting

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The ECOG-ACRIN SUPPORT Trial: Multilevel Intervention to Improve Diverse Enrollment in Cancer Clinical Trials

for Cancer

1 location in Chicago

Sponsor: Eastern Cooperative Oncology Group

Sex: All·Age: 18+

Code: NCT06756607·Recruiting

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New Strategies to Enhance Smoking Cessation

for Smoking Cessation

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06751927·Recruiting

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A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

for Metastatic Colorectal Cancer

Drug: Bevacizumab

12 locations incl. Duarte

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06820463·Phase 2·Recruiting

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A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

for Carcinoma, Non-Small-Cell Lung

Drug: Adagrasib

54 locations incl. Birmingham

Sponsor: Mirati Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06875310·Phase 3·Recruiting

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Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute Pancreatitis

for Severe Hypertriglyceridemia

Drug: Plozasiran

16 locations incl. Los Angeles

Sponsor: Arrowhead Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06880770·Phase 3·Recruiting

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Pivotal Study for the Cardiac Performance System (CPS)

for Cardiovascular Diseases

10 locations incl. Huntsville

Sponsor: Sensydia Corporation

Sex: All·Age: 18+

Code: NCT06870591·Recruiting

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Work2Prevent Plus: Structural Intervention to Promote HIV Care in Black Sexual Minority Men

for HIV

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06894199·Recruiting

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Normative Data for Sweating Rate, Sweat Sodium Concentration and Sweat Sodium Loss in Female Athlete

for Sweat Rate

1 location in Chicago

Sponsor: PepsiCo Global R&D

Sex: Female·Age: 13+·Accepts healthy volunteers

Code: NCT06995768·Recruiting

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A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE

for Lupus Erythematosus, Systemic

15 locations incl. San Francisco

Sponsor: AstraZeneca

Sex: All·Age: 18 - 70

Code: NCT06897930·Phase 1, Phase 2·Recruiting

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Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults

for Acute Respiratory Failure

9 locations incl. Chicago

Sponsor: Brian Driver

Sex: All·Age: 18+

Code: NCT06934876·Recruiting

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Evaluating the Effects of Tasimelteon vs. Placebo in Treating Pediatric Insomnia

for Insomnia Disorder

21 locations incl. Dothan

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 2 - 17

Code: NCT06953869·Phase 3·Recruiting

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Pivotal Study of Voro Urologic Scaffold

for Radical Prostatectomy

19 locations incl. Phoenix

Sponsor: Levee Medical, Inc.

Sex: Male·Age: 45+

Code: NCT06873581·Phase 3·Recruiting

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Understanding Individual Listening Strategies

for Hearing Loss, Sensorineural

1 location in Evanston

Sponsor: Northwestern University

Sex: All·Age: 18 - 90

Code: NCT06962540·Enrolling By Invitation

A Study to Evaluate the Clinical Outcomes of Efgartigimod PH20 SC in Adults With New-onset Generalized Myasthenia Gravis (gMG)

for New Onset Generalized Myasthenia Gravis (gMG)

Drug: Efgartigimod PH20 SC

18 locations incl. La Jolla

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT06909214·Phase 4·Recruiting

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A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism

for Tumor Hyperinsulinism (Tumor HI)

8 locations incl. Chicago

Sponsor: Rezolute

Sex: All·Age: 18+

Code: NCT06881992·Phase 3·Recruiting

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A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

for Stage I Mixed Cell Type Kidney Wilms Tumor

146 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT06401330·Phase 3·Recruiting

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Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors

for Advanced Solid Tumors

11 locations incl. San Diego

Sponsor: Pyxis Oncology, Inc

Sex: All·Age: 18+

Code: NCT06795412·Phase 1, Phase 2·Recruiting

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EXtubation Related Complications - the EXTUBE Study (EXTUBE)

for Extubation

6 locations incl. Tucson

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT06442930·Recruiting

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Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation

for Overweight or Obesity

Drug: Semaglutide

2 locations incl. Phoenix

Sponsor: University of Chicago

Sex: All·Age: 18 - 75

Code: NCT06499857·Phase 3·Recruiting

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A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-324 in Adult Participants With Hepatocellular Cancer (HCC) or Squamous-Cell Non-Small Cell Lung Cancer (LUSC)

for Hepatocellular Cancer

10 locations incl. Duarte

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06858813·Phase 1·Recruiting

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