Waveform Capnography Compared to Colorimetric Carbon Dioxide Detection During Tracheal Intubation of Critically Ill Adults

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Brian Driver
Study ID
NCT06934876
Status
Recruiting
Apply to this trial

Conditions

  • Acute Respiratory Failure

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Colorimetric carbon dioxide (CO2) detection — DIAGNOSTIC_TEST
    All patients will undergo colorimetric carbon dioxide (CO2) detection. The reading will be assessed by a clinician at the bedside who will answer yes or no to the following question, asked after 7 breaths have been delivered following intubation: "Is the color change consistent with a tube located in the trachea?"
  • Waveform capnography — DIAGNOSTIC_TEST
    All patients will undergo waveform capnography. The reading will be assessed by a clinician at the bedside who will answer yes or no to the following question, asked after 7 breaths have been delivered following intubation: " Is the waveform consistent with a tube located in the trachea?"

Study Details

This study will compare the sensitivity and specificity of waveform capnography versus colorimetric carbon dioxide detection to identify tracheal placement of the endotracheal tube during intubation of critically ill adults.

Key Dates

Start date
Apr 21, 2025
Status verified
May 2026
Primary completion
Dec 1, 2026
Completion
Jan 1, 2027

Study Design

Enrollment
2,092 participants (estimated)

Arms

  • Arm: Critically ill adults undergoing emergency tracheal intubation
    Adult patients who are undergoing emergency intubation in the ED and ICU

Primary Outcome Measure

Sensitivity of the test of exhaled carbon dioxide to detect a endotracheal tube positioned in the trachea. [ Time Frame: From intubation until 7 breaths from the ventilator are delivered, approximately 1 minute ]

Central Contacts

Locations (9)

FacilityCityStateZIPSite coordinators
Rush University Medical CenterChicagoIllinois60612
Kevin Buell, MD
[email protected]
(312) 942-5000
Lahey Hospital & Medical CenterBurlingtonMassachusetts01805
Avignat Patel, MD
[email protected]
781-744-5100
Hennepin HealthcareMinneapolisMinnesota55415
Brian Driver
[email protected]
612-873-7448
Regions HospitalSaint PaulMinnesota55101
Bjorn Westgard, MD
[email protected]
(651) 254-3456
Albany Medical CenterAlbanyNew York12208
Alexander Bracey, MD
[email protected]
(518) 262-3125
Duke University School of MedicineDurhamNorth Carolina27710
James Herbert, MD, PhD
[email protected]
(919) 684-8111
Wake Forest School of MedicineWinston-SalemNorth Carolina27157
John Gaillard, MD
[email protected]
336-758-5000
The Ohio State University College of MedicineColumbusOhio43210
Matthew Exline, MD
[email protected]
614-293-8000
Oregon Health and Sciences UniversityPortlandOregon97239
Akram Khan, MBBS
[email protected]
503-494-8311

Find similar trials in Chicago, IL

By research site
Rush University Medical Center· Chicago, ILLahey Hospital & Medical Center· Burlington, MAHennepin Healthcare· Minneapolis, MNRegions Hospital· Saint Paul, MNAlbany Medical Center· Albany, NYDuke University School of Medicine· Durham, NC

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