Paid Clinical Trials in Illinois

Illinois has 2,953 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,953 clinical trials

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A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

for Endometrial Cancer

44 locations incl. Mobile

Sponsor: Merck Sharp & Dohme LLC

Sex: Female·Age: 18+

Code: NCT06952504·Phase 3·Recruiting

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A Prospective Trial of a Variable Compression System for Moderate to Severe Irritable Bowel Syndrome

for IBS (Irritable Bowel Syndrome)

3 locations incl. Kissimmee

Sponsor: PGP Health

Sex: All·Age: 18 - 60

Code: NCT07540312·Recruiting

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MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels

for Coronary Artery Disease

24 locations incl. Gilbert

Sponsor: Concept Medical Inc.

Sex: All·Age: 18 - 80

Code: NCT06271590·Recruiting

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Study Evaluating the Safety and Efficacy of Neffy or Intramuscular Adrenalin in Patients With Allergic Reactions After Oral Food Challenge or Allergen Immunotherapy

for Allergic Reactions

6 locations incl. La Jolla

Sponsor: ARS Pharmaceuticals, Inc.

Sex: All·Age: 4+

Code: NCT06834165·Phase 4·Recruiting

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A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

for Chronic Lymphocytic Leukemia

20 locations incl. Jacksonville

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06876649·Phase 4·Recruiting

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A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma

for Chronic Lymphocytic Leukemia

18 locations incl. Miami

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06876662·Phase 4·Recruiting

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A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

for Heart Failure

Drug: Empagliflozin

105 locations incl. Mobile

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06935370·Phase 3·Recruiting

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A Study to Learn About the Study Medicine Called PF-07275315 in People With Moderate-To-Severe Asthma

for Asthma

Drug: PF-07275315

36 locations incl. Mobile

Sponsor: Pfizer

Sex: All·Age: 18 - 70

Code: NCT06977581·Phase 2·Recruiting

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J-Tip Use for Paracentesis in Adults With Ascites

for Evaluate Patient Comfort Level During Paracentesis by Numbing Skin With a Needle-less Device, Instead of Using a Needle to Numb the Skin

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06996379·Recruiting

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A Study to Check Liver Health in Boys With XLMTM, a Serious Genetic Muscle Condition

for X-Linked Myotubular Myopathy

6 locations incl. Chicago

Sponsor: Astellas Gene Therapies

Sex: Male·Age: Up to 17

Code: NCT06581146·Recruiting

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Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation

for Delayed Graft Function

32 locations incl. Phoenix

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06830798·Phase 3·Recruiting

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Pelacarsen Roll-over Extension Program

for Atherosclerotic Cardiovascular Disease

Drug: Pelacarsen

91 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT06875973·Phase 3·Recruiting

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A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo™ Aspiration System (STRIDE II)

for Lower Extremity Acute Limb Ischemia

31 locations incl. Scottsdale

Sponsor: Penumbra Inc.

Sex: All·Age: 18+

Code: NCT06747117·Recruiting

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Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

129 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06672146·Phase 2·Recruiting

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Optimizing Reperfusion to Improve Outcomes and Neurologic Function

for Acute Ischemic Stroke

17 locations incl. Long Beach

Sponsor: Corxel Pharmaceuticals

Sex: All·Age: 18 - 90

Code: NCT06990867·Phase 2, Phase 3·Recruiting

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A Bionic Breast Project Using Neuroprosthesis to Reduce Chronic Pain After Mastectomy

for Mastectomy

1 location in Chicago

Sponsor: University of Chicago

Sex: Female·Age: 18+

Code: NCT06382272·Recruiting

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Comparing The Safety And Efficacy Of DEFENCATH® In Reducing Central-Line Bloodstream Infections (CLABSIs) In Adults Receiving Total Parenteral Nutrition Through A Central Venous Catheter (CVC)

for Central Line Associated Blood Stream Infections (CLABSI)

17 locations incl. Los Angeles

Sponsor: CorMedix

Sex: All·Age: 18+

Code: NCT06822426·Phase 3·Recruiting

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Efficacy of Simbrinza and Rocklatan vs Cosopt and Latanoprost

for Open Angle Glaucoma

1 location in Springfield

Sponsor: Prairie Eye Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06883123·Phase 4·Recruiting

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Study of GS-0151 in Participants With Rheumatoid Arthritis

for Rheumatoid Arthritis

18 locations incl. Anniston

Sponsor: Gilead Sciences

Sex: All·Age: 18 - 75

Code: NCT06902519·Phase 1·Recruiting

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Randomized Withdrawal Study in Patients With Schizophrenia

for Schizophrenia

22 locations incl. Rogers

Sponsor: Vanda Pharmaceuticals

Sex: All·Age: 18 - 65

Code: NCT06961968·Phase 3·Recruiting

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A Long-term Safety and Efficacy Study Evaluating APG777 in Atopic Dermatitis

for Atopic Dermatitis

22 locations incl. Fountain Valley

Sponsor: Apogee Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07003425·Phase 2·Recruiting

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A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

for Prostate Cancer

50 locations incl. Phoenix

Sponsor: Merck Sharp & Dohme LLC

Sex: Male·Age: 18+

Code: NCT06925737·Phase 3·Recruiting

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Observation Study in Patients Age 0-5 Years With LAMA2-related Congenital Muscular Dystrophy

for LAMA2-MD \(Merosin Deficient Congenital Muscular Dystrophy, MDC1A\)

14 locations incl. Los Angeles

Sponsor: Nationwide Children's Hospital

Sex: All·Age: Up to 5

Code: NCT06503367·Recruiting

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Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant

for Amyloidosis

Drug: Acoramidis

39 locations incl. La Jolla

Sponsor: Eidos Therapeutics, a BridgeBio company

Sex: All·Age: 18 - 75

Code: NCT06563895·Phase 3·Recruiting

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CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)

for Type 1 Diabetes Mellitus

30 locations incl. Tucson

Sponsor: COUR Pharmaceutical Development Company, Inc.

Sex: All·Age: 12 - 35

Code: NCT06783309·Phase 1, Phase 2·Recruiting

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Study of Nutrition and Exercise in Adults Hospitalized for Treatment of Acute Lymphoblastic Leukemia (ALL)

for Philadelphia Chromosome Negative

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 50

Code: NCT06785324·Recruiting

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A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

for Moderately to Severely Active Crohns Disease

Drug: Afimkibart

50 locations incl. Glendale

Sponsor: Hoffmann-La Roche

Sex: All·Age: 16 - 80

Code: NCT06819891·Phase 3·Recruiting

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A Study of ZL-1310 in Participants With Selected Solid Tumors

for Solid Tumors

12 locations incl. San Francisco

Sponsor: Zai Lab (Shanghai) Co., Ltd.

Sex: All·Age: 18+

Code: NCT06885281·Phase 1, Phase 2·Recruiting

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Onyx™ Liquid Embolic IDE Clinical Study

for Peripheral Arterial Hemorrhage

18 locations incl. Phoenix

Sponsor: Medtronic Endovascular

Sex: All·Age: 22+

Code: NCT06742801·Recruiting

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Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula

for Pancreatic Carcinoma

118 locations incl. Birmingham

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06807437·Phase 3·Recruiting

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NBI-1117568-SCZ3029: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia

for Schizophrenia

Drug: NBI-1117568

21 locations incl. Bryant

Sponsor: Neurocrine Biosciences

Sex: All·Age: 18 - 65

Code: NCT06963034·Phase 3·Recruiting

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Microcurrent Stimulation Therapy for Intermediate to Advanced Nonexudative Age-related Macular Degeneration

for Age-Related Macular Degeneration

4 locations incl. Manchester

Sponsor: i-Lumen Scientific AUS PTY LTD

Sex: All·Age: 60+

Code: NCT06662162·Recruiting

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Ocular Assessments in Patients Treated With Tivdak® in Recurrent or Metastatic Cervical Cancer

for Cervical Cancer

92 locations incl. Phoenix

Sponsor: Pfizer

Sex: Female·Age: 18+

Code: NCT06952660·Phase 4·Recruiting

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A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

for Myelodysplastic Syndromes

23 locations incl. Duarte

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06499285·Phase 3·Recruiting

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Investigating an mRNA CAR T-cell Therapy, Known as Descartes-08, as a Potential Approach to Treat Myasthenia Gravis

for Myasthaenia Gravis

23 locations incl. Tucson

Sponsor: Cartesian Therapeutics

Sex: All·Age: 18+

Code: NCT06799247·Phase 3·Recruiting

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Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

for NSCLC (Non-small Cell Lung Cancer)

Drug: daraxonrasib

39 locations incl. Birmingham

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06881784·Phase 3·Recruiting

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Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

for Hepatocellular Carcinoma

Drug: Rilvegostomig

35 locations incl. Phoenix

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06921785·Phase 3·Recruiting

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Feasibility of Using the Gatorade Sports Science Institute (GSSI) Labs App for Hydration Related Outcomes

for Hydration

1 location in Chicago

Sponsor: PepsiCo Global R&D

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07005895·Recruiting

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Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial - Part 2

for Intracerebral Hemorrhage

48 locations incl. Birmingham

Sponsor: Joseph Broderick, MD

Sex: All·Age: 18 - 80

Code: NCT07227246·Phase 3·Recruiting

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Prostate Cancer Treatment Using Androgen Deprivation Therapy and Focal Prostate Ablation

for Prostate Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: Male·Age: 18+

Code: NCT05790213·Phase 2·Recruiting

Apply to this trial