Study of Nutrition and Exercise in Adults Hospitalized for Treatment of Acute Lymphoblastic Leukemia (ALL)

Part of paid clinical trials in Chicago, Illinois.

Sponsor
University of Chicago
Study ID
NCT06785324
Status
Recruiting
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Conditions

  • B Cell Acute Lymphoblastic Leukemia (B-ALL)
  • B-ALL
  • Philadelphia Chromosome Negative

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Not accepted

Interventions

  • Nutrition Intervention — BEHAVIORAL
    The nutrition intervention will target a 10% caloric deficit calculated from each patient's Basal Metabolic Rate (WHO/Schofield) utilizing a high protein (\>25%), low fat (\<25%), low glycemic index/high fiber (45-55%) diet. The study registered dietician (RD) will meet with the patient on day of enrollment to go over the "menu" of dietary options and will re-assess the patient every two days (excluding weekends) for adherence. My Plate (USDA) will control portion size and eating habits.
  • Exercise intervention — BEHAVIORAL
    The exercise intervention will target 200 minutes of "moderate" physical activity weekly, as defined by Metabolic Equivalents (METs) of 3-6, made up of aerobic and resistance training activities tailored to the patient's preference by working with the study physical therapist (PT). Physical Therapist to evaluate patient every 48 hours, excluding weekends.

Study Details

This clinical trial aims to assess the effect of nutrition and exercise on muscle and adiposity in adults with Philadelphia Chromosome (Ph) Negative B-ALL undergoing inpatient induction therapy. Participants will take part in 2 different interventions: * Nutrition Intervention * Physical Exercise Intervention All subjects will be provided with a wearable electronic activity monitor (FitBit®) to assist in recording activity levels in minutes of activity.

Key Dates

Start date
May 12, 2025
Status verified
Jun 2025
Primary completion
Nov 6, 2027
Completion
Nov 6, 2027

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE

Arms

  • Experimental: Nutrition and Exercise interventions
    Participants will receive an exercise and nutrition (diet) intervention while hospitalized for routine treatment for their ALL.

Primary Outcome Measure

Feasibility of nutrition and exercise intervention [ Time Frame: End of study recruitment (approximately 1 year) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Chicago Medicine Comprehensive Cancer CenterChicagoIllinois60637
Clinical Trials intake
[email protected]
855-702-8222
Wendy Stock (PRINCIPAL_INVESTIGATOR)

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By research site
University of Chicago Medicine Comprehensive Cancer Center· Chicago, IL

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