Paid Clinical Trials in Illinois

Illinois has 2,953 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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2,953 clinical trials

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Safety and Pharmacokinetics Study of PGT121.414.LS Alone and in Combination With VRC07-523LS in Infants Exposed to HIV-1

for HIV-1

11 locations incl. Los Angeles

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: Up to 72 Hours·Accepts healthy volunteers

Code: NCT06517693·Phase 1·Recruiting

Apply to this trial

A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

for Major Depressive Disorder

32 locations incl. Phoenix

Sponsor: Syndeio Biosciences, Inc

Sex: All·Age: 18 - 64

Code: NCT07115329·Phase 2·Recruiting

Apply to this trial

Comparative Efficacy of Nipocalimab and Efgartigimod in Participants With Generalized Myasthenia Gravis

for Myasthenia Gravis

Drug: Nipocalimab

11 locations incl. Fullerton

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 74

Code: NCT07217587·Phase 3·Recruiting

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A Multi-Site Feasibility Trial of Embedded Emergency Department Physical Therapy

for Low Back Pain

2 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07224945·Recruiting

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A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

for Metastatic Non-small Cell Lung Cancer With MTAP Deletion

Drug: Navlimetostat

42 locations incl. Anchorage

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07063745·Phase 2, Phase 3·Recruiting

Apply to this trial

Short-Term Health Outcomes of Cooking UFP Exposure

for Cognitive Function Decline

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07311967·Not Yet Recruiting

Neuromusculoskeletal Interface for Bionic Arms

for Amputation

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 70

Code: NCT07032753·Not Yet Recruiting

Supraglottic Airway for Resuscitation Trial

for Neonatal Resuscitation

30 locations incl. Birmingham

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 Days+

Code: NCT07150923·Recruiting

Apply to this trial

Assessment of a Method to Improve Cochlear Implant Users' Speech Perception in Noisy Environments While Maintaining Their Ability to Determine Where a Sound Originates From

for Cochlear Implant Users

1 location in Champaign

Sponsor: University of Illinois at Urbana-Champaign

Sex: All·Age: 18+

Code: NCT07323862·Not Yet Recruiting

Arm and Leg Cycling for Accelerated SCI Recovery

for Spinal Cord Injury

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 75

Code: NCT06873776·Enrolling By Invitation

Caring Contacts Via Text Message for Suicidal Adolescents After Emergency Department Discharge

for Suicide Prevention

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 12 - 17

Code: NCT07043764·Not Yet Recruiting

A Sequential Phase 2/3 Study of APL2 in Patients With Focal Segmental Glomerulosclerosis

for FSGS

2 locations incl. Chicago

Sponsor: Apellis Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT07213960·Phase 2, Phase 3·Not Yet Recruiting

A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

for Untreated, Unresectable, or Metastatic Colorectal Cancer

Drug: Bevacizumab

49 locations incl. Tucson

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT07221357·Phase 2, Phase 3·Recruiting

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Clinical Utility of an Amniotic Membrane Allograft for Diabetic Foot Ulcer Wound Management

for Diabetic Foot Ulcer

8 locations incl. Palm Springs

Sponsor: Legacy Medical Consultants

Sex: All·Age: 50 - 85

Code: NCT06420245·Recruiting

Apply to this trial

Hyperangulated Versus Standard Geometry Laryngoscope Blade Trial

for Acute Respiratory Failure

16 locations incl. Los Angeles

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07223762·Enrolling By Invitation

Efficacy and Safety of KAI-9531 Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes

for Obesity

Drug: Semaglutide

26 locations incl. Glendale

Sponsor: Kailera

Sex: All·Age: 18+

Code: NCT07284979·Phase 3·Recruiting

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AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer

for Epithelial Ovarian Cancer

17 locations incl. Fort Lauderdale

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT07218809·Phase 3·Recruiting

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A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis

for Atopic Dermatitis

Drug: Tapinarof

37 locations incl. Birmingham

Sponsor: Organon and Co

Sex: All·Age: 3 Months - 23 Months

Code: NCT07265479·Phase 3·Recruiting

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A Dose-ranging Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Galvokimig in Adult Study Participants With Atopic Dermatitis

for Atopic Dermatitis

20 locations incl. Oceanside

Sponsor: UCB Biopharma SRL

Sex: All·Age: 18+

Code: NCT07277660·Phase 2·Recruiting

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Pain Management for In-Office Gynecologic Procedures Using a Risk-Stratification Pain Calculator

for Pain Management

2 locations incl. Champaign

Sponsor: Carle Foundation Hospital

Sex: Female·Age: 18+

Code: NCT07311824·Not Yet Recruiting

Study to Evaluate Resmetirom in Post-Liver Transplant Patients With MASH

for MASH - Metabolic Dysfunction-Associated Steatohepatitis

16 locations incl. La Jolla

Sponsor: Madrigal Pharmaceuticals, Inc.

Sex: All·Age: 18 - 75

Code: NCT07335601·Phase 2·Recruiting

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A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

for Breast Neoplasms

117 locations incl. Anchorage

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07174336·Phase 3·Recruiting

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Phase 2A/B Efficacy and Safety of Dabogratinib in Participants With Low Grade Upper Tract Urothelial Carcinoma

for Low Grade Upper Tract Urothelial Carcinoma

7 locations incl. Lisle

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT07265947·Phase 2·Recruiting

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Lateral Plantar Artery Embolization For Plantar Fasciitis

for Plantar Fasciitis, Chronic

1 location in Libertyville

Sponsor: Joint & Vascular Institute

Sex: All·Age: 25 - 80

Code: NCT07395128·Phase 1·Recruiting

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A Study to Evaluate the Safety and Effectiveness of the Rapidlink Device When Used in Patients Undergoing an Open Surgical Procedure to Repair the Aorta

for Aortic Aneurysm

16 locations incl. Los Angeles

Sponsor: Vascutek Ltd.

Sex: All·Age: 18+

Code: NCT07078383·Recruiting

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Phase 1/2 Study of MZ-1866, an AAV-9 Gene Therapy Delivered by Intracerebroventricular Injection to Participants With Pitt Hopkins Syndrome

for Pitt Hopkins Syndrome

3 locations incl. Oakland

Sponsor: Mahzi Therapeutics

Sex: All·Age: 2 - 25

Code: NCT07135050·Phase 1, Phase 2·Recruiting

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A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer

for Prostatic Neoplasms, Castration-Resistant

Drug: Pasritamig

49 locations incl. Chandler

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT07225946·Phase 3·Recruiting

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A Study to Assess the Safety, Tolerability, Efficacy, Pharmacokinetics, and Immunogenicity of Intravenous Administration of ARGX-119 in Pediatric Participants Aged 5 to Less Than 18 Years With Spinal Muscular Atrophy

for Spinal Muscular Atrophy (SMA)

17 locations incl. Little Rock

Sponsor: argenx

Sex: All·Age: 5 - 17

Code: NCT07287982·Phase 2·Recruiting

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Open-Label Phase 1/2 Study of NEO-811 in Subjects With Locally Advanced or Metastatic Non-Resectable Clear Cell Renal Cell Carcinoma

for Clear Cell Renal Cell Carcinoma

10 locations incl. Duarte

Sponsor: Neomorph, Inc

Sex: All·Age: 18+

Code: NCT07300241·Phase 1·Recruiting

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Study Evaluating the Safety and Efficacy of HWK-007, a PTK7-directed Antibody Drug Conjugate in Participants With Advanced Solid Tumors

for Endometrial Cancer

12 locations incl. Little Rock

Sponsor: Whitehawk Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07444814·Phase 1·Recruiting

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Upadacitinib as a Novel Treatment for Refractory Eyelid Dermatitis

for Eyelid Dermatitis

Drug: Upadacitinib

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 70

Code: NCT06684522·EARLY_Phase 1·Recruiting

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A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062)

for Human Immunodeficiency Virus Type 1 (HIV-1) Infection

24 locations incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07266831·Phase 2, Phase 3·Recruiting

Apply to this trial

A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

for Major Depressive Disorder

Drug: Icalcaprant

33 locations incl. Dothan

Sponsor: AbbVie

Sex: All·Age: 18 - 65

Code: NCT07276997·Phase 2·Recruiting

Apply to this trial

Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes

for Obesity

23 locations incl. Anniston

Sponsor: Kailera

Sex: All·Age: 18+

Code: NCT07284875·Phase 3·Recruiting

Apply to this trial

Study to Evaluate Efficacy and Safety of Firmonertinib Compared With Investigator's Choice of EGFR Inhibitor as First-Line Treatment in Participants Who Have Locally Advanced or Metastatic NSCLC With EGFR P-Loop and Alpha C-Helix Compressing (PACC) Uncommon Mutations

for Non-Small-Cell Lung Cancer

16 locations incl. Los Angeles

Sponsor: ArriVent BioPharma, Inc.

Sex: All·Age: 18+

Code: NCT07185997·Phase 3·Recruiting

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A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of ABBV-243 in Healthy Adults.

for Healthy Volunteers

1 location in Grayslake

Sponsor: AbbVie

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07306754·Phase 1·Recruiting

Apply to this trial

Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer

for Non-small Cell Lung Cancer

70 locations incl. Phoenix

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06686771·Phase 3·Recruiting

Apply to this trial

Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines

for Migraine

1 location in Oak Lawn

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06904287·Phase 3·Recruiting

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Luspatercept + Darbepoetin in MDS

for MDS (Myelodysplastic Syndrome)

3 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07096297·Phase 2·Recruiting

Apply to this trial

Study of DONQ52 in Active Celiac Disease

for Celiac Disease

Drug: DONQ52

49 locations incl. Anniston

Sponsor: Chugai Pharmaceutical

Sex: All·Age: 18 - 75

Code: NCT07239336·Phase 2·Recruiting

Apply to this trial