Effectiveness of Magnesium in Addition to Prochlorperazine for the Treatment of Migraines

Part of paid clinical trials in Oak Lawn, Illinois.

Sponsor
Wake Forest University Health Sciences
Study ID
NCT06904287
Phase
PHASE3
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Magnesium — DRUG
    Prochlorperazine 10 mg administered as an intravenous push over 2 minutes followed by magnesium 2 g administered as an intravenous bolus over a period of 20 minutes
  • Placebo — DRUG
    Prochlorperazine 10 mg administered as an intravenous push over 2 minutes followed by placebo (normal saline)

Study Details

The purpose of this research study is to find out if using magnesium in addition to prochlorperazine will help reduce your migraine pain.

Key Dates

Start date
Dec 16, 2025
Status verified
Jan 2026
Primary completion
Jun 30, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Study Drug
    Prochlorperazine 10 mg followed by Magnesium 2 g
  • Active Comparator: Control Arm
    Prochlorperazine 10 mg followed by placebo

Primary Outcome Measure

Mean change in pain - baseline to 30 minutes [ Time Frame: Baseline to 30 minutes after initiation of infusion ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Advocate Christ Medical Center Emergency DepartmentOak LawnIllinois60453
Samar Ashrafi, PharmD
[email protected]
708-684-7895

Find similar trials in Oak Lawn, IL

By condition
Migraine
By specialty
Neurology
By research site
Advocate Christ Medical Center Emergency Department· Oak Lawn, IL

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