Clinical Trials at Duke University

As of June 2026, 200 paid clinical trials are recruiting at Duke University, located at 2301 ERWIN ROAD EMERGEENCY MEDICINE RESIDENCY, DURHAM, NC 27710-0001, phone (919) 681-2247 in Durham, North Carolina. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 12, 2026.

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200 clinical trials at Duke University

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Opioid Treatment and Peer Recovery Support

for Opioid-use Disorder

3 locations incl. Durham

Sponsor: Brown University

Sex: All·Age: 18+

Code: NCT04978168·Recruiting

Apply to this trial

Randomized Phase IIB Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in PTCL

for PTCL

6 locations incl. Long Beach

Sponsor: University of Virginia

Sex: All·Age: 18+

Code: NCT04747236·Phase 2·Recruiting

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PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches

for Aneurysm

10 locations incl. Aurora

Sponsor: Vascutek Ltd.

Sex: All·Age: 18+

Code: NCT04545502·Recruiting

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Adherus™ Dural Sealant in Spinal Procedures

for Spinal Duraplasty

14 locations incl. Duarte

Sponsor: Stryker Craniomaxillofacial

Sex: All·Age: 18 - 75

Code: NCT04498026·Enrolling By Invitation

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

for Advanced Solid Tumor

32 locations incl. Irvine

Sponsor: PMV Pharmaceuticals, Inc

Sex: All·Age: 12+

Code: NCT04585750·Phase 1, Phase 2·Recruiting

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Lumbar Interbody Implant Study

for Degenerative Disc Disease

16 locations incl. La Jolla

Sponsor: NuVasive

Sex: All·Age: 18+

Code: NCT04418830·Enrolling By Invitation

Neural Correlates of Real World Spatial Navigation in Humans

for Memory, Delayed

2 locations incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 12 - 70·Accepts healthy volunteers

Code: NCT04874220·Recruiting

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ROSE-Longitudinal Assessment With Neuroimaging

for Intracerebral Hemorrhage

7 locations incl. Chicago

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18+

Code: NCT05089331·Recruiting

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GSD VI and GSD IX Natural History

for Glycogen Storage Disease VI

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 0 - 90

Code: NCT04454216·Recruiting

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Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults

for Cognitive Impairment, Mild

102 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 75+·Accepts healthy volunteers

Code: NCT04262206·Phase 4·Recruiting

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ADRC Clinical Cohort (Alzheimer's Disease)

for Alzheimer Disease

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 25 - 80·Accepts healthy volunteers

Code: NCT06703541·Recruiting

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Cervical Interbody Implant Study

for Degenerative Disc Disease

7 locations incl. Orange

Sponsor: NuVasive

Sex: All·Age: 18+

Code: NCT04689854·Enrolling By Invitation

HEALEY ALS Platform Trial - Master Protocol

for Amyotrophic Lateral Sclerosis

81 locations incl. Phoenix

Sponsor: Merit E. Cudkowicz, MD

Sex: All·Age: 18+

Code: NCT04297683·Phase 2, Phase 3·Recruiting

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A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)

for Myelodysplastic Syndromes

Drug: Venetoclax

24 locations incl. Los Angeles

Sponsor: Taiho Oncology, Inc.

Sex: All·Age: 18+

Code: NCT04256317·Phase 2, Phase 3·Recruiting

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Global Utilization And Registry Database for Improved heArt preservatioN

for Heart Diseases

17 locations incl. Stanford

Sponsor: Paragonix Technologies

Sex: All·Age: All ages

Code: NCT04141605·Enrolling By Invitation

Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

for Atrial Fibrillation

51 locations incl. Little Rock

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT04045665·Phase 3·Recruiting

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Prophylactic Reinforcement of Ventral Abdominal Incisions Trial

for Open Midline Laparotomy

30 locations incl. Phoenix

Sponsor: C. R. Bard

Sex: All·Age: 18+

Code: NCT03911700·Recruiting

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A Prospective Registry of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS).

for Hematopoietic Cell Transplantation

3 locations incl. Rochester

Sponsor: Duke University

Sex: All·Age: 0 - 26

Code: NCT05090345·Recruiting

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Cenobamate Open-Label Extension Study for YKP3089C025

for Primary Generalized Tonic Clonic Seizures in the Setting of Idiopathic Generalized Epilepsy

Drug: Cenobamate

16 locations incl. La Jolla

Sponsor: SK Life Science, Inc.

Sex: All·Age: 12+

Code: NCT03961568·Phase 3·Enrolling By Invitation

Phase III DAS181 Lower Tract PIV Infection in Immunocompromised Subjects (Substudy: DAS181 for COVID-19): RCT Study

for Lower Respiratory Tract Infection

49 locations incl. Duarte

Sponsor: Ansun Biopharma, Inc.

Sex: All·Age: All ages

Code: NCT03808922·Phase 3·Recruiting

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Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)

for Non-Hodgkin Lymphoma

18 locations incl. Gilbert

Sponsor: Imugene Limited

Sex: All·Age: 18+

Code: NCT03666000·Phase 1·Recruiting

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Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

for Infant, Extremely Premature

37 locations incl. Birmingham

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 0 - 1

Code: NCT05685745·Recruiting

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Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance

for Ascending Aortic Aneurysm Enlargement

15 locations incl. San Francisco

Sponsor: Ottawa Heart Institute Research Corporation

Sex: All·Age: 18 - 79

Code: NCT03536312·Recruiting

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Advanced Materials Science in XLIF Study

for Degenerative Disc Disease

15 locations incl. Hartford

Sponsor: NuVasive

Sex: All·Age: 18 - 80

Code: NCT03649490·Enrolling By Invitation

Clinical Procedures to Support Research in ALS

for Amyotrophic Lateral Sclerosis

11 locations incl. Irvine

Sponsor: University of Miami

Sex: All·Age: 18+

Code: NCT03489278·Recruiting

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Maternal Autoimmune Disease Research Alliance (MADRA) Registry

for Autoimmune Diseases

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: All ages·Accepts healthy volunteers

Code: NCT03276923·Recruiting

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Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

for Heart Failure With Preserved Ejection Fraction

38 locations incl. Alexander City

Sponsor: Uppsala University

Sex: All·Age: 50 - 99

Code: NCT02901184·Phase 3·Recruiting

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Abductor Reattachment Methods in Proximal Femur Replacements: What is the Best Method?

for Sarcoma

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 16 - 75

Code: NCT03261544·Recruiting

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International Registry for Men With Advanced Prostate Cancer (IRONMAN)

for Prostate Cancer

48 locations incl. Birmingham

Sponsor: Prostate Cancer Clinical Trials Consortium

Sex: Male·Age: 21+

Code: NCT03151629·Recruiting

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Effects of Stimulation Patterns of Deep Brain Stimulation

for Parkinson Disease

3 locations incl. Gainesville

Sponsor: Duke University

Sex: All·Age: 21 - 80

Code: NCT02553525·Enrolling By Invitation

Pilot Study for Speculum Free Cervical Cancer Screening

for Cervical Cancer

1 location in Durham

Sponsor: Duke University

Sex: Female·Age: 21 - 65·Accepts healthy volunteers

Code: NCT04107181·Recruiting

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Neuroblastoma Maintenance Therapy Trial

for Neuroblastoma

42 locations incl. Birmingham

Sponsor: Giselle Sholler

Sex: All·Age: 1 - 30

Code: NCT02679144·Phase 2·Recruiting

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Idiopathic Pulmonary Fibrosis and Interstitial Lung Disease Prospective Outcomes Registry

for Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease

44 locations incl. Birmingham

Sponsor: Duke University

Sex: All·Age: 21+

Code: NCT01915511·Recruiting

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Pharmacokinetics of Drugs Administered to Children

for Pediatric ALL

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 0 - 20

Code: NCT03481881·Recruiting

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Proton or Photon RT for Retroperitoneal Sarcomas

for Retroperitoneal Sarcoma

10 locations incl. Chicago

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT01659203·Phase 1, Phase 2·Recruiting

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Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

for Huntington's Disease

62 locations incl. Birmingham

Sponsor: CHDI Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT01574053·Recruiting

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Natural History Study of SCID Disorders

for Severe Combined Immunodeficiency (SCID)

39 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: All ages

Code: NCT01186913·Enrolling By Invitation

Spinal Cord Injury Registry - North American Clinical Trials Network

for Spinal Cord Injury

13 locations incl. Miami

Sponsor: Robert G. Grossman, MD

Sex: All·Age: 18+

Code: NCT00178724·Recruiting

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Follow-up Visit of High Risk Infants

for Infant, Newborn

31 locations incl. Birmingham

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: 18 Months - 26 Months

Code: NCT00009633·Recruiting

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Generic Database of Very Low Birth Weight Infants

for Infant, Newborn

31 locations incl. Birmingham

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: Up to 14 Days

Code: NCT00063063·Recruiting

Apply to this trial